ID A0A1S3PKR7_SALSA Unreviewed; 439 AA.
AC A0A1S3PKR7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 2 {ECO:0000256|ARBA:ARBA00039299};
GN Name=spred2 {ECO:0000313|RefSeq:XP_014028186.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014028186.1};
RN [1] {ECO:0000313|RefSeq:XP_014028186.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014028186.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004413};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004413};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004413}. Cytoplasmic vesicle,
CC secretory vesicle membrane {ECO:0000256|ARBA:ARBA00004360}; Peripheral
CC membrane protein {ECO:0000256|ARBA:ARBA00004360}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004360}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR RefSeq; XP_014028186.1; XM_014172711.1.
DR AlphaFoldDB; A0A1S3PKR7; -.
DR GeneID; 106585934; -.
DR OrthoDB; 3031266at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR11202:SF11; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR11202; SPROUTY-RELATED, EVH1 DOMAIN-CONTAINING PROTEIN FAMILY MEMBER; 1.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS51227; SPR; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 5..122
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 206..262
FT /note="KBD"
FT /evidence="ECO:0000259|PROSITE:PS51488"
FT REGION 121..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..166
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49729 MW; 1BB12808F1D15E70 CRC64;
MTEETHPDDD SYIVRVKAVV MTRDDSSGGW LAQDGGCLSR VGVCKVLSAE LLGRSSFLIH
GERLKDKQVI LECFLKKDLV YTKATPTFHH WKVDNKKCGL TFQSPADARA FDRGVRKAME
DLTEGSTTSS STIQNEAELG DDDVFTNATD SSSNSSHSQK KEPLQLQTLA PPSFCEPRRH
NCILGHFYDQ HRPSDHYFLD QSVPMFPRHV RFQVEEEEIV RINPRERTWL TGYEDYRHAT
ATRNKLIQHP ENADAYVHFA KSEPPKHDYT YPYPLGLDPH QHARDPKIGC VDRLGGGGLI
GGHRAVVTAQ PRTLQLKVKR RKEDGERSRC VYCRDMFNHE ENRRGRCQEA PDPIQTCIHR
VSFMWCADSL LYHCMSDPEG DYSDPCSCDT SDERFCLRWL ALVGLSLLAP CMCCYAPLRA
CYRCGVACHC CGGKHKAVG
//
