ID   A0A1S3PKU1_SALSA        Unreviewed;       370 AA.
AC   A0A1S3PKU1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Zinc phosphodiesterase ELAC protein 1 {ECO:0000313|RefSeq:XP_014027974.1};
GN   Name=elac1 {ECO:0000313|RefSeq:XP_014027974.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014027974.1};
RN   [1] {ECO:0000313|RefSeq:XP_014027974.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014027974.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR   RefSeq; XP_014027974.1; XM_014172499.1.
DR   AlphaFoldDB; A0A1S3PKU1; -.
DR   STRING; 8030.ENSSSAP00000104646; -.
DR   PaxDb; 8030-ENSSSAP00000104646; -.
DR   GeneID; 106585828; -.
DR   KEGG; sasa:106585828; -.
DR   CTD; 55520; -.
DR   OMA; GTQRQMM; -.
DR   OrthoDB; 5471005at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa24.
DR   Bgee; ENSSSAG00000076040; Expressed in ovary and 16 other cell types or tissues.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016891; F:RNA endonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR   GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd07717; RNaseZ_ZiPD-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   HAMAP; MF_01818; RNase_Z_BN; 1.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR013471; RNase_Z/BN.
DR   PANTHER; PTHR46018; ZINC PHOSPHODIESTERASE ELAC PROTEIN 1; 1.
DR   PANTHER; PTHR46018:SF2; ZINC PHOSPHODIESTERASE ELAC PROTEIN 1; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   3: Inferred from homology;
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          20..74
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|Pfam:PF00753"
SQ   SEQUENCE   370 AA;  40727 MW;  AC7A9C01A086F3A2 CRC64;
     MTMDLTFLGT GSAYPSPHRG ASALVLRTEG ECWLFDCGEG TQTQLMKSQL KASRITKVFI
     SHLHGDHLFG LPGLLCTVSL NLNPCPTQPP TCVDIYGPQG LRQFLRVALE LTSSQLLFPY
     SVHELEPTTD QCPTEGQLSP DVTADSGRLH PQERAGRTIP LDVNSDCYVI LEEKRFVVKA
     FRLFHRVPSF GFSVQEHDWP GRLNTELLKD LGLKPGPLYG RLKAGESVTL ENGQVVKPSE
     VLEEAIPGRK VCVLGDCSSL LGEGPLRACH RADILVHEAT LSDEHREKAV DHGHSTPSMA
     AAVAQACCAR MLVLYHFSQR YKPAGQHKEG DEDDVLELRR QAEEALQGTG IEVSLAEDFL
     TIPIPLIRLH
//