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Database: UniProt
Entry: A0A1S3PLQ8_SALSA
LinkDB: A0A1S3PLQ8_SALSA
Original site: A0A1S3PLQ8_SALSA 
ID   A0A1S3PLQ8_SALSA        Unreviewed;       678 AA.
AC   A0A1S3PLQ8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   08-MAY-2019, entry version 11.
DE   RecName: Full=Receptor protein serine/threonine kinase {ECO:0000256|SAAS:SAAS00138132};
DE            EC=2.7.11.30 {ECO:0000256|SAAS:SAAS00138132};
GN   Name=LOC106586172 {ECO:0000313|RefSeq:XP_014028587.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014028587.1};
RN   [1] {ECO:0000313|RefSeq:XP_014028587.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014028587.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-serine + ATP = [receptor-protein]-O-
CC         phospho-L-serine + ADP + H(+); Xref=Rhea:RHEA:18673, Rhea:RHEA-
CC         COMP:11022, Rhea:RHEA-COMP:11023, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:29999, ChEBI:CHEBI:30616, ChEBI:CHEBI:83421,
CC         ChEBI:CHEBI:456216; EC=2.7.11.30;
CC         Evidence={ECO:0000256|SAAS:SAAS01128400};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[receptor-protein]-L-threonine + ATP = [receptor-
CC         protein]-O-phospho-L-threonine + ADP + H(+);
CC         Xref=Rhea:RHEA:44880, Rhea:RHEA-COMP:11024, Rhea:RHEA-
CC         COMP:11025, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.30; Evidence={ECO:0000256|SAAS:SAAS01128404};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. TKL Ser/Thr
CC       protein kinase family. TGFB receptor subfamily.
CC       {ECO:0000256|SAAS:SAAS00595019}.
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DR   RefSeq; XP_014028587.1; XM_014173112.1.
DR   GeneID; 106586172; -.
DR   OrthoDB; 776697at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004675; F:transmembrane receptor protein serine/threonine kinase activity; IEA:InterPro.
DR   InterPro; IPR003605; GS_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR000333; TGFB_receptor.
DR   PANTHER; PTHR23255; PTHR23255; 3.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF08515; TGF_beta_GS; 1.
DR   SMART; SM00467; GS; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51256; GS; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|SAAS:SAAS00138218};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Kinase {ECO:0000256|SAAS:SAAS00138139};
KW   Membrane {ECO:0000256|SAAS:SAAS00138203, ECO:0000256|SAM:Phobius};
KW   Nucleotide-binding {ECO:0000256|SAAS:SAAS00138212};
KW   Receptor {ECO:0000256|SAAS:SAAS00138179,
KW   ECO:0000313|RefSeq:XP_014028587.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00138186};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transferase {ECO:0000256|SAAS:SAAS00138167};
KW   Transmembrane {ECO:0000256|SAAS:SAAS00138220,
KW   ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00488859,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     20       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        21    678       Receptor protein serine/threonine kinase.
FT                                {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5010171765.
FT   TRANSMEM    293    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      347    376       GS. {ECO:0000259|PROSITE:PS51256}.
FT   DOMAIN      377    671       Protein kinase. {ECO:0000259|PROSITE:
FT                                PS50011}.
SQ   SEQUENCE   678 AA;  74633 MW;  E4DCBE87F9577A29 CRC64;
     MLDGDMFFLV FILLVLPSSS VKDEGSVSDY ECACDGPSCD GGDRCFGQRC FSALSVQNAI
     SVQQKGCIVE RSEESISCES PPSHNLTVEC CHGDLCNMNV TVATPATVEE VMPALQDIEC
     VCEGRSCDGG ERCTGQQCFS SVKTSDGFVV HQKGCLQDDD QGRATCATPP SPSHIVKCCQ
     GHLCNLNITV EAPAKEDKVK SAGEHECVCE GRSCATGWRC IGQHCFSSLT VSDGGLVFQK
     GCFKVYEQSR MTCKTPPSRD QIVECCQGHL CNMNITVELP VIGELPNYSL TTLAIVIVAP
     VIVLIVLSGI AILVFRRIHQ NQMERLTARE AEYGTIDGLI ASNVGDSTLA DLLDHSCTSG
     SGSGLPFLVQ RTVARQITLN ECVGKGRYGE VWRGQWQGES VAVKIFSSRD EKSWFRETEI
     YNTVLLRHEN ILGFIASDMT SRNSSTQLWL ITHFHEMGSL YDYLQLSTLD TASCLRMALS
     IASGLAHLHV EIFGTQGKPA IAHRDLKSKN ILVNKNGQCC IADLGLAVMH FQDTNELDVG
     NNPKVGTKRY MAPEVLDDSI QMDCFESFKR VDIWAFGLVL WEIARSTVSN GIVEDYKPPF
     HDAVPSDPSF EDMKKVVCVD QQRPNIPNRW FSDPTLTSIA KLMKECWYQN PSARLTALRI
     KKTLTKIDNS LDKIKTDC
//
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