ID A0A1S3PMB3_SALSA Unreviewed; 581 AA.
AC A0A1S3PMB3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Caspase-8-like isoform X1 {ECO:0000313|RefSeq:XP_014028796.1, ECO:0000313|RefSeq:XP_014028797.1};
GN Name=LOC106586254 {ECO:0000313|RefSeq:XP_014028796.1,
GN ECO:0000313|RefSeq:XP_014028797.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014028797.1};
RN [1] {ECO:0000313|RefSeq:XP_014028796.1, ECO:0000313|RefSeq:XP_014028797.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014028796.1,
RC ECO:0000313|RefSeq:XP_014028797.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR RefSeq; XP_014028796.1; XM_014173321.1.
DR RefSeq; XP_014028797.1; XM_014173322.1.
DR STRING; 8030.ENSSSAP00000101573; -.
DR PaxDb; 8030-ENSSSAP00000101573; -.
DR GeneID; 106586254; -.
DR KEGG; sasa:106586254; -.
DR OMA; NDFRNSP; -.
DR OrthoDB; 2873736at2759; -.
DR Proteomes; UP000087266; Chromosome ssa25.
DR Bgee; ENSSSAG00000074890; Expressed in nose and 13 other cell types or tissues.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd00032; CASc; 1.
DR CDD; cd08334; DED_Caspase_8_10_r2; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF5; CASPASE 10; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 2..79
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 92..159
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 331..457
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 486..571
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
FT REGION 299..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 299..313
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 581 AA; 64591 MW; 1D07BE28D8E14F33 CRC64;
MDFQRLLLQV EQALSSEEVQ ALAFLCKDLL DKDLNSVTTA SKLFSLLMDQ ELLSPDQPYL
LADLLLTIQR NSLMRGLGLN NQLPTTSSLI SPYRKLLYNL SENITTDELR EIKFLLSNEL
PRRKLEDNLT TLQLFLEMEK IDILSIIKLN TLESIFGIVC PMLKTTIKKY KTQNSLAGPG
TQETGVGQFR PRSVSVSVSE AHPGIQAASM LPKRTVFCEL SVEQYSHSDE TLIPPTYFSS
SQPSAKVSCL NRSDTSLADV RRVSYSMDAV LSHGLSLLST NGDNCAALIK EYHHVSSTSS
CGDNKNFGPA DPQTGNTKRE ELGEYSMTGK KRGFCLIINN NDFRNSPQLL KEREGTHIDK
KSLVSVFNWL GFETQTEPDC SREKILSLLV ELSKRDHSQM DCLVCCVLSH GLEGGVYGVD
GLEVSVRELT KPFSGLECSS LRDKPKLFFI QACQGNKDQK QVFIQSDGPG PSSTTTSSIC
TDAVVHRDSI PTDADFLLGM ATVPHFASFR DKKLGTWFIQ SLCQNLINLV PSGYDLLSIL
TKVNDDVSRK TNGIKKQMPQ PAYSLRKRVV FPIPKEPPPK L
//
