ID A0A1S3PQ23_SALSA Unreviewed; 1039 AA.
AC A0A1S3PQ23;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Ras and Rab interactor 2-like isoform X1 {ECO:0000313|RefSeq:XP_014029768.1};
GN Name=LOC106586723 {ECO:0000313|RefSeq:XP_014029768.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014029768.1};
RN [1] {ECO:0000313|RefSeq:XP_014029768.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014029768.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000256|ARBA:ARBA00006919}.
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DR RefSeq; XP_014029768.1; XM_014174293.1.
DR AlphaFoldDB; A0A1S3PQ23; -.
DR GeneID; 106586723; -.
DR KEGG; sasa:106586723; -.
DR OrthoDB; 5483004at2759; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR Gene3D; 1.20.1050.80; VPS9 domain; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; RAB GDP/GTP EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23101:SF51; RAS AND RAB INTERACTOR 2; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF109993; VPS9 domain; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 3: Inferred from homology;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191}.
FT DOMAIN 139..235
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 751..891
FT /note="VPS9"
FT /evidence="ECO:0000259|PROSITE:PS51205"
FT DOMAIN 921..1012
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 263..318
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..597
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..295
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..418
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..445
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 543..559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1039 AA; 115106 MW; 9C06C1B61079A113 CRC64;
MAATLPSTLH STLPRPDCHM DRSGSFFKDS DGLTDSDLSM SATLPRPDCH MDRRGSFFKL
IDTFALEIGE LKQEMVQTSP TEDRDPYPMV LQGLEGEVSG VYLQSSPCAG ASGERDSGYD
SLRRRMSVLD RLRHTHPVWL LLTLSDTEAT RILLQQPPGV FLVRKSSTLQ RKVLSLRVSE
DDASGGASVC DFPVRESQYT FSLEGSGISF ADLFRLVAFY CISRDILPFT LNLPEAIAAS
KTQKDLEEVA QLGAGFWHSA LGSLRRTTSP SRPPPQRPDR DGDNQGAERT QEKQSVTRHS
SVPPAFPPSS SSSRLERSQS NGALCFVNPL FLQTHRRLEE DPQSSSTSPS PYVTHSTPSP
GTTGGTSSAP VTDPNVKRKS RPPRPPPPRS LLVPPPRSLS QRRQAPPPPT PLPQKPKSSM
PETPAAIVVT RQPLQPSSNQ NLRPTPRPPM GARHSSHSKK TTSSAAMPVP HHHPQHPPPP
RPKKPDIDAH RCHIALDDET IAKALSRAKL PPCQAPAIVG NGAGSPPSPP GKTPRREGQE
GRLSDMSIST SSSDSLDYSH PPLSLPASPP LRLRHHLGNN EDSSDDEDLC DEEEEDYGVS
LENDLDQGLR PPFKARRRGV GVGVKVALSF RKVSGVFSTF MTPERRAVRR IAALSRDKSS
YFGCLVQDYI SFVQENKGCH TSGLDLLQTL RQFMTQMKAY LTQSSELDPP IESLIPEDQI
DTVLEKAMHK CVLKPLKGVV EVALHDFQVS SGGWQQLREN LALAKTRRPQ DLGVDGAVPP
DPMAIEKIRH KFHNMRKMYS PDKKVSLLLR VCKLIYTIMQ DNSGRMYGAD DFLPMLTYVL
AQCDMPQLDT EILYMMELLD PSLLHGEGGY YLTSAYGAMA LIKNFQEEQA ARVLSSEARD
TLHQWHRRRT AQRTAPSVDD FQNYLRVALQ EVNSGCTAKT LLVHPYSTTE EVCSLCTYKF
KVHDPENHAL FLITEATSQQ LAPDTHPQRI KAEIHSHPNS QPFHFVYRRV PNLNLCIPAI
PANQHNGNCL LPSQLDELN
//
