ID A0A1S3PQE8_SALSA Unreviewed; 945 AA.
AC A0A1S3PQE8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Peripheral plasma membrane protein CASK-like isoform X5 {ECO:0000313|RefSeq:XP_014029898.1};
GN Name=LOC106586786 {ECO:0000313|RefSeq:XP_014029898.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014029898.1};
RN [1] {ECO:0000313|RefSeq:XP_014029898.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014029898.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the MAGUK family.
CC {ECO:0000256|ARBA:ARBA00007014}.
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DR RefSeq; XP_014029898.1; XM_014174423.1.
DR AlphaFoldDB; A0A1S3PQE8; -.
DR GeneID; 106586786; -.
DR OrthoDB; 2873706at2759; -.
DR Proteomes; UP000087266; Chromosome ssa25.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR CDD; cd00071; GMPK; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd12035; SH3_MPP1-like; 1.
DR CDD; cd14094; STKc_CASK; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.620; -; 1.
DR Gene3D; 3.30.63.10; Guanylate Kinase phosphate binding domain; 1.
DR Gene3D; 1.10.287.650; L27 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR008145; GK/Ca_channel_bsu.
DR InterPro; IPR008144; Guanylate_kin-like_dom.
DR InterPro; IPR020590; Guanylate_kinase_CS.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR014775; L27_C.
DR InterPro; IPR004172; L27_dom.
DR InterPro; IPR036892; L27_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR23122; MEMBRANE-ASSOCIATED GUANYLATE KINASE MAGUK; 1.
DR PANTHER; PTHR23122:SF40; PERIPHERAL PLASMA MEMBRANE PROTEIN CASK; 1.
DR Pfam; PF00625; Guanylate_kin; 1.
DR Pfam; PF02828; L27; 2.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00072; GuKc; 1.
DR SMART; SM00569; L27; 2.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF101288; L27 domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00856; GUANYLATE_KINASE_1; 1.
DR PROSITE; PS50052; GUANYLATE_KINASE_2; 1.
DR PROSITE; PS51022; L27; 2.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 12..277
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 344..399
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 415..472
FT /note="L27"
FT /evidence="ECO:0000259|PROSITE:PS51022"
FT DOMAIN 507..588
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 631..701
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 758..930
FT /note="Guanylate kinase-like"
FT /evidence="ECO:0000259|PROSITE:PS50052"
FT REGION 475..497
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 591..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 945 AA; 107461 MW; 4E5ECE448C3D61D9 CRC64;
MADDDVLFED VYELCEVIGK GPFSVVRRCI NRDAGQQFAV KIVDVAQFTS SPGLSTEDLK
REASICHMLK HPHIVELVET YSSDGMLYMV FEFMDGSDLC FEIVKRADAG FVYSEAVASH
YMRQILEALR YCHDNNVIHR DVKPHCVLLA SKENSAPVKL GGFGVAIQLG ESGLVAGGRV
GTPHFMAPEV VKREPYGKPV DVWGCGVILF ILLSGCLPFY GTKERLFETI CRGKYKVLNP
RHWGHISESA KDLVRRMLML DPAERITVYE ALNHPWLKER DRYAYKIHLL ETVEQLRKFN
ARRKLKGAVL AAVSSHKFNS FYGDPPEEMP DFSEDPTSSG LLVAERAVSQ VLDSLEEIHA
LTDCSEKDID FLHSVFQDEH LHTLLDLYDK INTKSSPQIR NPPSNTVQRA KESSIQDEAS
SALKHLEYVL EEISCYPDNH DAKELRRILT QPHFMALLQT HDVVAHEVYS DEALRVTPPP
TSPYLNGESP ESTNGDMDLE NVTRVRLVQF QKNTDEPMGI TLKMNNLNHC IVARIMHGGM
IHRQGTLHVG DEIREINSIS VANQTVEQLQ RMLKEMRGSI TFKIVPSYRT QGSSCERESP
SNTRQSPANG TGHSSVNSFI LDLPSTVQPK SRQIYVRAQF EYDPSRDDLI PCKEAGIPFR
VGDIVQIISK DDHNWWQGKL ENTKNATAGL IPSPELQEWR VACLAMEKTK QEQQASCTWF
GKKKKQYKDK YLAKHNAVFD QLDLVTYEEV VKLPAFKRKT LVLLGAHGVG RRHIKNTLIT
KHPDRFAYPI PHTTRLPKKD EENGKNYYFV SHDQMMQDIS NNDYLEYGSH EDAMYGTRLE
TLRQIHEQGL ISILDVEPQA LKVLRTAEFA PYVVFIAAPT ITPGINEDES LQHLQKESEI
LQKTYAHYFD QTIINNEIDE TIRHLEEAID LVCTNAQWIP VSWVY
//
