ID A0A1S3PRP3_SALSA Unreviewed; 970 AA.
AC A0A1S3PRP3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Solute carrier family 12 member 2-like isoform X2 {ECO:0000313|RefSeq:XP_014030370.1};
GN Name=LOC106587038 {ECO:0000313|RefSeq:XP_014030370.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030370.1};
RN [1] {ECO:0000313|RefSeq:XP_014030370.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030370.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
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DR RefSeq; XP_014030370.1; XM_014174895.1.
DR AlphaFoldDB; A0A1S3PRP3; -.
DR OrthoDB; 5490251at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015377; F:chloride:monoatomic cation symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR002443; SLC12A1/SLC12A2.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF105; SOLUTE CARRIER FAMILY 12 MEMBER 2-LIKE; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 1.
DR Pfam; PF03522; SLC12; 1.
DR PRINTS; PR01207; NAKCLTRNSPRT.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..113
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 134..154
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..193
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..271
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 283..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..388
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 421..441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 447..464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 476..494
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 56..558
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 567..970
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 970 AA; 107218 MW; B62AE9749469ECC7 CRC64;
MRRNNGNHLR NNRKEPLDED GFPIGEESTL AEEAAAKEGT KEQAKGGTIK FGWVKGVLIR
CMLNIWGVML FIRMSWIVGQ AGIGLTCVII LMATVVTTIT GLSTSAIATN GFVRGGGAYY
LISRSLGPEF GGSIGLIFAF ANAVAVAMYV VGFAETVVEM LNDVDALMTD ELNDVRIVGT
LTVILLLGIS VAGMEWEAKA QIVLLVILLA AIFNYFIGTV ITMESKEPKG FFGYKAAIMM
ENMGPDFRDG ETFFSMFAIF FPAATGILAG ANISGDLTDP QSAIPKGTLL AILITGITYV
AVTVSTGSCI LRDATGDHND TSSVSGLNCT DAACTLGYDF SICKEGGCKF GLMNDFQVMS
LVSGFGPLIT AGIFSATLSS ALASLVSAPK VFQALCKDNI YPGLHVFAKG YGKNNEPLRG
YVLTFCIGLA FILIAELNVI APIISNFFLA SYALINFSVF HASLANSPGW RPSFKYFNKW
VSLAGAVLCC AVMFVVNWWA ALMTNIIVLA LYVYVSYKKP DVNWGSSTQA LIYNHALTHC
LLLTGVEDHV KNFRPQCLVM TGYPNARPAL LHLVNAFTKN VGLMVCGHVR TVSRRPNFKE
MSLDHARYQR WLLKNRIKAF YTPVFAEDLR HGAQYLLQAT GLGRLKPNTL VMGFKNNWSD
GEMKDVEMYI NIIHDAFDLQ HGVVIIRLQE GLDISHIQDP DELLSSHEKK DVGMKDVVVS
VNMVGKDSED SNSFPPSLIT SAQNSPLILR ETKRSAKPLS LTDQRLLEAS QQFKKKQCKG
TVDVWWLFDD GGLALLIPYL LTEKKKWKDC KIRLFIGGKI NRIDHDRRAM AALLSKFRID
FSAIYVLGDI NTKPKKHNVL SFEEMIEPYK LKEDDMEQDA AERLKAEEPW RISDNELELY
RAKTNRQIRL NELLKEHSNS AKLIVMSMPL ARKGTVSSAL YMCWLETLSK DLPPILLVRG
NHQSVLTFYS
//
