ID A0A1S3PRS3_SALSA Unreviewed; 406 AA.
AC A0A1S3PRS3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Homer protein homolog 1 isoform X1 {ECO:0000313|RefSeq:XP_014030400.1};
GN Name=homer1 {ECO:0000313|RefSeq:XP_014030400.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030400.1};
RN [1] {ECO:0000313|RefSeq:XP_014030400.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030400.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Postsynaptic density {ECO:0000256|ARBA:ARBA00034105}. Synapse
CC {ECO:0000256|ARBA:ARBA00034103}.
CC -!- SIMILARITY: Belongs to the Homer family.
CC {ECO:0000256|ARBA:ARBA00023606}.
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DR RefSeq; XP_014030400.1; XM_014174925.1.
DR AlphaFoldDB; A0A1S3PRS3; -.
DR STRING; 8030.ENSSSAP00000076913; -.
DR PaxDb; 8030-ENSSSAP00000076913; -.
DR GeneID; 106587049; -.
DR KEGG; sasa:106587049; -.
DR CTD; 436769; -.
DR OrthoDB; 5490527at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0014069; C:postsynaptic density; IEA:UniProtKB-SubCell.
DR GO; GO:0035256; F:G protein-coupled glutamate receptor binding; IEA:InterPro.
DR GO; GO:0007216; P:G protein-coupled glutamate receptor signaling pathway; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0061061; P:muscle structure development; IEA:Ensembl.
DR CDD; cd01206; EVH1_Homer_Vesl; 1.
DR Gene3D; 1.20.5.1700; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045027; Homer.
DR InterPro; IPR044100; Homer_EVH1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR10918; HOMER; 1.
DR PANTHER; PTHR10918:SF3; HOMER PROTEIN HOMOLOG 1; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50229; WH1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 47..159
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT REGION 159..223
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 232..384
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 168..198
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 406 AA; 45776 MW; 74F2FA63CE16BCCE CRC64;
MEGGGELVIR LPGRSHSPDN NGNSNFGLGE FGQTMVLRHK EVHHFFLAPF REQPIYSTRA
HAFQIDPNTK KNWVPTSKHA VTVSYFYDST RNVYRIISLD GTKAIINSTI SPNMTFTKTS
QKFGQWADSR ANTVYGLGFS TEHHLTKFAE KFAEYKEAAR QAKGKSQNGK MELATSPSQE
SPAGELSSPL TPVTPPAMDN INGTDDPCDT TPEPRPEPSQ NALAFTHSPS INKHWEAELS
ALKGNNAKLT AALLESTANV KQWKQQLAAY QEEAERLHKR VTELECQSTQ TPVIKSQKTE
LNQTIEELES ALKDKEEEME RLKEEVENAN ELLEQRHSLT QKLQETELHG RVLEEQLLGA
EQRLEESQEE QENFRKSLRT LLEMLDGKIF ELTELRDSLA KLIEGS
//
