ID A0A1S3PSP4_SALSA Unreviewed; 4903 AA.
AC A0A1S3PSP4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Ryanodine receptor 3-like isoform X3 {ECO:0000313|RefSeq:XP_014030707.1};
GN Name=LOC106587081 {ECO:0000313|RefSeq:XP_014030707.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030707.1};
RN [1] {ECO:0000313|RefSeq:XP_014030707.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030707.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR RefSeq; XP_014030707.1; XM_014175232.1.
DR OrthoDB; 3144451at2759; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF9; RYANODINE RECEPTOR 3; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 3.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|RefSeq:XP_014030707.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4232..4254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4444..4464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4512..4531
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4655..4680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4703..4725
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4784..4807
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 103..158
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 165..210
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 218..272
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 278..335
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 602..800
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1016..1212
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1282..1489
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 3964..3990
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 3625..3647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4139..4171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4351..4414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4144..4169
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4356..4414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4903 AA; 555980 MW; 866803ACF27F348C CRC64;
MAEGGEGEDE IQFLRTDDEV VLQCVACIHK ENRKFCLTAE GLGNRLCYLE PTSEAKYVPP
DLCICNFVLE HSLSVRALQE MLAKTGQNSE GRLIRKAAQG GGHRTLLYGH AILLRHSFSA
MYLTCLKTSR SQTDKLSFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVS
SERYLHLSIS NGNIQVDASF MQTLWNVHPT CSGSNVEEGY LLGGHVLRLF HGHDEVLTIP
GSDQSDEQQR IVNYETGNAG AKARSLWRLE PLRISWSGSH IPWGQPFRLR HLTTGHYLSL
TEERGVVLQD REKSDTSSTA FCFRASKEKL ESSPKRDIEG MGMAEIKYGD SICFVMHVAT
GLWLSYQAPD VKSSRLGPLK RRAFLHSEGH MDDGLTLQRC QHEESRAARI IRNTTRLFSH
FIRDLDCLGG KNRASVALPI EEVLQTLYDL ITYFQLPDAE LEHEEKQIML RSLKNRQNLF
KQEGMLTLVS CCIDRLNVYN SAAHFGECAG AEAGASWKEI LNLLYELLAA LIRGNRNNCT
QFSNNLDWLV SKLERLESSS GILEVLHCIL TESPEALNII QRGHIKSIIS LLYKHGRNHK
ILDVLCSLCV CNGVAVRANQ NLICDHLLPK RDLLLQTRLV NDVQSMRPNI FLGLSEGSAQ
YKKWYYELMI DQVDHFLTSD PSHLRVGWAT NKGYAPYPGG GEGWGGNGVG DDLYSYGFDG
LHLWSGRISR AVASINQHIL TSEDVVSCCL DLGAPSISFR INGQPVQGMF ENFNIDGLFF
PVVSFSAGVK VRFLLGGRHG DFKFLPPSGY APCYEALLPK EKMKVEPVKE YKRDMEGVRD
LLGTTQFMSQ ASFIPTPVET SQIVMPPYLE KVRDRLAENI HELWGMNKIE LGWSYGKIRD
DNKRQHPCLV DFSKLPETEK NYNLQMSTET LKTLLALGCH VVQVNANAEE DLKKIKLPKN
YMMSNGYKPT PLELSDVKVT PGQELLVEKL AENAHNVWAK DRIKQGWTYG IQQDVKSKRN
PRLVPYSLLD ERTKKSNRDS LREAIRTLIG YGYNIEPPDQ DGAGHVVERL SIDKIRFFRV
ERTYAVLTGK WYFEFEAVTG GDMRVGWARP GCKPDVELGT DELAFVFDGY KGHRLNMGSR
FFGRCWQAGD VVGCMINMED KSMIFTLNGE ILITNKGSEL CFADFETEDG FIPVCSLGLS
QVGRMNLGKD ASTFKYYTMC GLQEGFEPFA VNMNREVTMW FSKRLPTFFN VPKNNNHIMV
TRIDGTIDSP PCLKVSHRTF GTQNSNGDMV YCRLSMPVEF HSFFKTSPVM DMNGVHEEHE
SLKLKHRHPL KSMRHSHDGI RGTDYSNITT YYYSVRVFAG QDPSCVWVGW VTPDYHYYSN
HFNLSKNRTV TVTLGDERGR VHESVRRSNC YMVWGGDATS SGHSSSRSNV DLEIGCLIDL
ATGLVTFTVN GKELATSYQV EPNTKLFPAV FVRPTSPNLF QFELAKIKNT MPLSAAIFKS
EHKNPVPQCP PRLDVQTINS VLWSRMPNTF LKVETARVSE RHGWVVQCLE PLQMLAVHIP
EENRCVDIME LSEQEDLRMF HYHTLKLYCA LCALGNTRVA HALCSHLDQS QLLYTIDNQY
LSGMLREGFY NVLISVHLET AKEARLMMNN EFIIPVTAET RSIRLFSDAS KHHSPPGVGL
STSLKPRLNF YPPCFISTKR EQHLYSPQIP LDALKEKAIT MLTEAVQGGG HHIRDPVGGS
VEYQFVPILR LIGTLLTMGV LGSQDVHKIL LLIDPNVFAE HHEEAAAAVM EATEKEGLTG
AEEKAVEAGE EEAAKEAKQP IKGLLEKRLP EPVKRQMCEL LHYFCDCELK HRIEAIVSFS
DSFVSKLQYN QKFRYNELML ALNMSAAVTA KKTKEFRSPP QEQINMLLNF STGEDCPCPE
DIQEELYAFH NELRLHCGIP MEEEDEEQDR SIKGRLLALV YKIKGQPLKT EEEPTEQEQQ
APSNLKELIS QTMVSWAQEC HVQDPELVRV MFSLLRRQYD SIGELLRAMR KSYTISAASI
QDTINLLASL GQIRSLLSVR MGKEEEKLMI DGLGDIMNNK IFYQHPNLMR VLGMHETVME
VMVNVLGGGK SQEIAFPKMV ASCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA
MRGSTPLDVA ASSVMDNNGL ALALEEPDLD KVVTYLAGCG LQSCPMLLDK GYPDIGWNPI
EGERYLSFLR FAVFVNGESV EENSSVVVKL LIRRPECFGP ALRGEGGNGL LAAMKEAIKI
SDNPAVDLPS SAQGVSSDAS AEDDEEEEVV HMGNAIMSFY SALIDLLGRC APEMHLINKG
KGEALRIRAI LRSLVPTEDL VGIISIPLKM PVVHKDGTVT EPDMAASFCP DHKAPMVLFL
DRVYGIEDQS FLLQLLDVGF LPDLQASASL DTEVLSTTET ALAMNRYIGS AMLPLLTRCA
PHFAGTEHYA VLIDSTLHTI YRLSKGRSLT KAQRDAIEEC LLAVCKYLRP SMLQHLLRRL
VFDVPLLTEY CKMPLRLLTN HYEQSWKYYC LPSGWGSYGM ASDEELLLTK KIFWGVLDSL
SQRKYDADLF KMAMPCLSAI SGALPPDYID ATISTTLEKP VSVDAQGNFD PKPISTANIS
LPEKLEHVAN KYAEHSHDKW SAEKVMLGWR YGDCIDEKAK THPLLRTYKG LTEKEKDIYR
WPVRETLKTM LAMGWNIDRT KDGETMSLRE SEKMRKISQS SSHANGFNPT PIDTINVVLS
RELQGMVEVV AENYHNIWAK KKKNDLGIRG GATHPLLVPY DTLTAKEKAR DKEKAQDLFR
FLQINGYAIT RGLKDMEQDS SSMEKRFAYK FLKKLLKYVN SAQEFIAHLE VMATSGKTDK
SPHEQEIKFF AKVLLPLIDQ YFKNHCLYFL SSPSKNLSSS GYASNKEKEM VTSLFCKLAA
LVRHRISLFG SDSTTMVSVL HILAHTLDTR TVMKSGSELV KAGLRTFFEN AAEDLEKTLE
NLKLGKFTHS RSQMKGVSQN INYTTVALLP ILTALFEHIT QHHFGVDLLL DDVQVSCYRI
LTSLYALGTG KNIYVERQLP ALGECLATLA GAMPVAFLEP LLNKHNPCSV FNTKTARERA
ILGMPDAVEE MCPEMPRLDV LMKDINDMSE SGARYTEMPH VIEVVLPMLC NYLSYWWEKG
PENQESPHSG GSVGGSVFST TVTSEHLSLI LGNILKILNS NLGIDEASWM KRIAVYAQPI
ITKARAVLLK SHFLPTLEKL KKKTVKVVTE EELLKADSKG DTQEAELLIL DEFAVLCRDL
YAFYPMLIRY VDNNRSRWLK EPDADSNELF RMVAEIFILW CKSHNFKREE QNFVVQNEIN
NLSFLTGDSK IKMSKSGGQD QERKHKRKRG EFYSIQTSLI VAALKKMLPI GLNMCTPGDQ
ELISLAKTRY ILKDTDDEVK EHLRQNLHLQ EKSEDPAVRW QLNLYKDVMV KNEGPPDPER
TVFRVQSISA AVFHLEQVEQ PLRSKKCVWQ KLLSKQRKRA VVACFRMAPL YNLPRHKSNN
YFLNAYRRYW LEKMHENTDY DSLLSMLTKT QLKVEEEEEE EAEMQPDPLH QLILHFSHNA
LTERSSLEED PLYIAYADMM AKSCAEDEEE EDEEGKEKTF EEKEMEKQKT LYQQARLHDR
GAAEMVLQMI SASRGSLGPM VTFTLKLGIS ILNGGNILVQ QKMLDYLKEK RDAGFFKSLS
GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SINVSERGSK VLQNDEFTKD LFRFLQLLCE
GHNNDFQNFL RTQTGNTTTV NIIISTVDYL LRLQESISDF YWYYSGKDIM DEAGQRNFSK
ALAVAKQIFN SLTEYIQGPC IGNQQSLAHS RLWDAVVGFL HVFANMQMKL SQDSSQIDLL
KELLDLQKDM IVMMLSLLEG NVVNGTIGKQ MVDTLVESSS NVEMILKFFD MFLKLKDLTS
SDNFKEYDPD SKGVISKKEF QKSMENQKQY SQSEIEFLLS CVEADENDMF NYEEFVERFH
EPAKDIGFNV AVLLTNLSEH MPHDARLATF LDLAESVINY FEPYLGRIEI MGGAKRIERV
YFEISESSRT QWEKPQVKES KRQFIFDVVN EGGESEKMEL FVNFCEDTIF EMQLASQISE
PDSVERLEEE EEDSQSVEEE EEEEEEESMM ESHSAFTNSC VSMRKNLSSF RQLLTFKSMR
RQYRNFRKMS VREMVRGLFS FFWKIITGLF RFLYNLVWGF FHILWSSMFG GGLVEGAKNM
KVTDILGNMP DPTQFGIHGD VLEAEKMEAS EASSVAEMVQ MAQGDKAEAD LMAELLNIQT
KSQGGKHAAE PGLGDMGEVV GVDAPSLASA VKQKKAKEAA TMEPANGDHK AEPEKADPED
EEKKDKDKAK EETPPESPPE EEKKAPKKRP GLKKEPPEAF MARFFSGLEI YQTKMLNYLA
RNFYNLRFLA LFVAFAINFI LLFYKVTGDD GDDDDPDPWN GGGGTDEEDD EGGMEYFVLQ
ESTGYMAPTL RFLAILHTVI SFLCVVGYYY LKVPLTVFKR EKEIARKLEF DGLYITEQPS
DDDIKGQWDR LVINTPSFPN NYWDKFVKRK VINKYGDLYG AERIAELLGL DKSALDFNPT
EETVLKEASL VSWLSSVDTK YQCWKMGVVF TDNSFLYLVW YTTMSILGHY NNFFFAAHLL
DIAMGFKTLR TILSSVTHNG KQLVLTVGLL AVVVYLYTVV AFNFFRKFYN KSEDENQPDM
KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDPYELYRI LFDITFFFFV IVILLAIIQG
LIIDAFGELR DQQEQVKEDM ETKCFICGIG NDYFDTTPHG FETHTLQEHN LANYLFFLMY
LINKDETEHT GQESYVWKMY QERQWDFFPA GDCFRKQYED QLG
//
