ID A0A1S3PSU3_SALSA Unreviewed; 2541 AA.
AC A0A1S3PSU3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Polycystic kidney disease protein 1-like 2 {ECO:0000313|RefSeq:XP_014030757.1};
GN Name=LOC106587186 {ECO:0000313|RefSeq:XP_014030757.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030757.1};
RN [1] {ECO:0000313|RefSeq:XP_014030757.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030757.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR RefSeq; XP_014030757.1; XM_014175282.1.
DR STRING; 8030.ENSSSAP00000104712; -.
DR PaxDb; 8030-ENSSSAP00000104712; -.
DR GeneID; 106587186; -.
DR KEGG; sasa:106587186; -.
DR CTD; 497373; -.
DR OMA; EEQKHYQ; -.
DR OrthoDB; 52189at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR Bgee; ENSSSAG00000076052; Expressed in actinopterygian pyloric caecum and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR CDD; cd00037; CLECT; 1.
DR CDD; cd22831; Gal_Rha_Lectin_PKD1L2; 1.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.120.740; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 3.10.100.10; Mannose-Binding Protein A, subunit A; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000922; Lectin_gal-bd_dom.
DR InterPro; IPR043159; Lectin_gal-bd_sf.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF195; POLYCYSTIC KIDNEY DISEASE 1 LIKE 2A-RELATED; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF02140; Gal_Lectin; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
DR PROSITE; PS50228; SUEL_LECTIN; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2541
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010186341"
FT TRANSMEM 1402..1422
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1610..1630
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1650..1672
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1895..1917
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1929..1962
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2021..2043
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2267..2287
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2307..2324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2356..2376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2396..2418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2454..2483
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..161
FT /note="C-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50041"
FT DOMAIN 169..261
FT /note="SUEL-type lectin"
FT /evidence="ECO:0000259|PROSITE:PS50228"
FT DOMAIN 969..1181
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1447..1564
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1677..1715
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1861..1889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2517..2541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1677..1691
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1694..1709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1861..1888
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2525..2541
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2117..2130
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2541 AA; 280192 MW; 12178B9FB2C62154 CRC64;
MDSTNLSVLL LNAFLLSLSC AEDEIAPLSC PEYQEGFDGS CYEFVGLPRS RSFLSAQGWC
ERGGGHLAFI LNDETQQFLQ KHLQPEQDWW LGLAPASPNL TLDSAAAAEG PLSWLDGSDV
SYSNWVNDPD PGAGCGHILR SSGFQWEATN NCSQELHFIC QFESGRSIAC ADHNATLQCG
SGQVIEIDDS FYGRKTVHYC RTSPASSATS TQEECSWIDV VDSVTGDCHG LQACQATADV
ASFGEPCPGL GSYLSVEYNC KEGLHLLMSK LAAVFDNVSI TVKWLLHPFQ GNLTCTLSAG
DGHNIDPYSP EELESSVVHK YTRPGVFMVG VECTTSEWHV TAQKAITIQE PIGEFGVIMC
YSMNQSIDGA NCKALYGSPL QIQVEVEAGT NVTYKIHRGE MLVANSLAVR GIVPHNITVG
PEVEQQLGSG CHQLTLHASN GVSVLGVSTE LQVCLLEPVE GLLGSVMAEE GECPDSDLYV
RVSLDRGAPV QLLFQVSGAN GSISETRDMQ NRSTQVYNIS TTIQGALQVK VRAWNVFSHM
DVDVGNTAAV CHNKSDFQTE EHKRLPRANV EITSDPESPS DFTQSVTLGL TGLSGVPGIS
EPGIQLQWEC NEQCKCRDKT NQETHVITAA CLPDPFIFYI YSFTVQKKNG PGAQVAKAEK
CITVTPPEFT DVTISCSNCN PVNINNDVTL KLECTTAMSC PKVVWHVEDT RPLTGDLKHC
YKTAKQRPLL HRIDGGNEYM VTSDNLKNAQ SRSLNLNVIA YGKTTSGVAK YTIQIPGVAT
PAPVATNIPP ATTLPAATTI LPAVTTRPAA TTIPLVATTL LAATTIAATT TVSVTVPEKT
APTTIANLHS CIISPQSGTV LDAFNITCAT TSCSTGKCQY CFKTDKDKHL RCSYGNEVKS
IFLPLGNKSY NYSLSVVVTL TNGDRKTNAT ITTEVWPANS SSSVENLQSV VENTVAQLQQ
QRLLTGETLG QMFKSVSDIL NKDSSEDQKG AREELREQML STMTAVLKNV PNNTPQEVQL
TARAVAGITK RREEVNSAAQ LEASSLVADL SSSLLYMNVS EHGGEEMAQA ATPIVDAASN
ILGVSSNAST QRKVSKILLN SMDNVQSALL NGKKVGQEPA IIKSPEISVY ANRMSPNSIQ
MQSINIPDSS SASFSFPPLG ADVLSPEEPV DVRMLSFEKN PYSWSEGGNI SGAMGSVSLT
RQDGSAIPVE NLSEEIEILL PRLEGGQVNS TILDLGNYST LMIDVPSPDI TLVLKMEPSE
DIPFVLLLGY KDYPKDKQYI AKTQMPHQGN SQERYTWVLG PNDLAGKVGV HYLVVRPIVV
AGVKSVNATV TVTSIAAQCK YWNETLSTWS EDGCRVGHLT TPLVTQCLCN HLTFFGSSFF
IMPNLVDVSR TAELFATFSD NPVVVCFVGA IFVAYLLVVM WARRKDIQDI AKVKVTLLED
NDPLAEYRYM LNISTGHRRG ASTSSQVTVT LLGTEGESEP HHLTDPDKPV FERGAVDTFV
LTTPFSLGEL QSIRLWHDNS GGHPAWYVNK VTVQDLEIGQ KWHFLCNSWL AIDMGECILD
KVFPVASDID LKKFSNLFFM KTAKDFRDGH IWFSVISRPP TSTFTCVQRV SCCFSLLLCT
MLTSIMFWGI PTDPSEQTMD LGHIEFTWQQ VMIGVQSSII MFPINLLIVS IFRNTRPRET
KPGKPKAEVS KQGKTGRVTP SQPPSPQRER ELTPDTVIKD IKKIAQSLSK AMKSPIPCLE
LEMKPGPQTD INTLLSLVED IIRQQNRAGG EFYTDASKKE GSLILSLGVA NLQETSLCGS
PDKTGDGRQK RSNNSQYLYR QLRHVEKELS LLGPSRFPNP DSYCRAVQQV QGMRGLLESH
LSSSSLGGDQ LSQSPSPAES SEGDSSSKKQ GGLPWWFVFI GWILVLATSG VSGYFTMMYG
LTYGKDRSIS WLISMVVSFF ESLFITQPLK VLGFAAFFAL VLKKVDQEEY GDAKFEGELR
NPDDPDVVRA VRRDSTCSFY QPPPPTDIER MRSNMIKEQK VFALIKEILT YMGFMWMLLL
VAYGQRDPNA YLLTQHIRQS FSQGISDSMS HKDVFTWANT SLLSNLFGEY PGFITDGNSK
LVGNARLRQV RVQKNSCRIA RSMRQAVPDC HAPYSWEVED MGSYGPGWNR SASENTSKTL
RSPWQYQTQA RLRAQPIWGS VVLYRGGGFV VDLGPESQNA SSTLQYLFDN TWLDMFTRAV
FVEFTVYNAN VNLFCTVTLM LETTAVGAFQ FRSELQSVRL YQSTGGLHIF VMASEVIYFL
FILYYMYVQG KLMKQQKWAY FKTKWNLLEL AIILLSWSAL SVFIKRTLLG NRDMEYYHNH
KDQFASFHET ATADAVLGYL IAFLVLLATV KLWHLLRLNP KLHMITATLQ RAWTDISGFL
VVITIMFLAY SIASYLMYGW KLYSYRTLLD AALTMVSLQL GIFNYDEVLD YNPVLGAFLI
GSCIIFMTFV VLNLFISVIL VAFTQEQIHH KPSEEEEVVD LMLMKLCSLF GIKMKEEKED
SPKENGMTAS ATNRGFSTIS S
//
