ID A0A1S3PT01_SALSA Unreviewed; 1882 AA.
AC A0A1S3PT01;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myotubularin-related protein 13-like isoform X4 {ECO:0000313|RefSeq:XP_014030818.1};
GN Name=LOC106587205 {ECO:0000313|RefSeq:XP_014030818.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030818.1};
RN [1] {ECO:0000313|RefSeq:XP_014030818.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030818.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_014030818.1; XM_014175343.1.
DR OrthoDB; 3195274at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd13339; PH-GRAM_MTMR13; 1.
DR CDD; cd01235; PH_Sbf1_hMTMR5; 1.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR004182; GRAM.
DR InterPro; IPR037823; MTMR13_PH-GRAM.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR022096; SBF1/SBF2.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF4; MYOTUBULARIN-RELATED PROTEIN 13; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF02893; GRAM; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF12335; SBF2; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00568; GRAM; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00800; uDENN; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50211; DENN; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 6..435
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT DOMAIN 1119..1621
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT DOMAIN 1776..1880
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1072..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1882 AA; 210841 MW; B8937FF18B12B713 CRC64;
MARLADYLIV VRLDQDKTGA GEGCGKIIQR FPKKDWEGTV FPQGVEMFCQ PGGWRLSRER
KAPTFFTVVL TDIDSDRHYC SCLTFYEAEV NLQGTKTTDA DEDEEEDGLI QPAQVFAPKS
LILVSRLDYP EIFRGCLGLI YTVYVDSLPF PLEGLVSNLF TCMVPVAGGS QKLFSLGVGD
RQLIQTPLND NLPVTCKSVA LLFQQLGIQN VLSLFCAVLT EHKVLFHSTS YQRLGEASRA
LEALMFPLKY SYPYIPILPS RLLEVLSSPT PFIIGVHSMF QSEIQELWCV LSVLQLDVII
ADLDGGTIKI PECIHLSQLP EPLLHTTQTA LSLVLHPDLE IADNAFPPPR TAPSNLKLLD
KEVRAVFLRL FAQLFQGYRS CLQLIRIHSE PVIHFHKTAF LGQRGLIEND FLTKVLDGMA
FAGFVSERGP PYRACDLFDE LVAFDMERFK EEAASPAKLQ KHMRELSDQL YKNENPNPHM
AFQKVPRPTE GSHLRVHVMP FPLLDDEKVE RLLAEGLAKH PSTPAITTTT RAERKCVVPA
GPPVVSIMGK MGSVFNSARR LEVVRSCISF IFDNKTQETE KTLPAALRAL KGKAARQCLT
EELSLHVQQN RAILDHQQFD YVIRMMNCAL QDCSSSEEYA VASALLPLTT AFYRKLPAGV
SQFAYTCVQD HPIWTNQQFW EATFYSEVQN QIRALYLTAP EDKLGITARL KEQGPLPPAA
PSASERTAMD LAAEQLRAWP CLSKEKQQEL VKNEESTVFS QAIHYASLLV YLLVPLDTSK
NKLLRANPVA DWESGSNSIV TNSIAGSMAE SFDTESGFED SENSDVANSV VRFIARFIDK
VCTESGVSQD HIKSLHSMIP GIVAMQMETL EAVHRESRRL PPIQKPKILR PALLPGEEFV
SEGLRVVLDP DGREEATGGM LGGPHILPAE GALFLTSYRI IFKGSPHDPL VGEQAVIRSF
PVSTLTKEKK ISVQNQLQQN MQEGLQLRSA SFQLIKVAFD EEVSSEMVEI FRKHVQRIRY
PQSIFSTFAF AAGQTAPQLI LPKQKERNTG FRTLSKTIVK GAKRAGMITM GRQSQTTLKK
NDRGSRMTWH EDDDISVSDE GEPPPSSTLR ASEKSTMEQL VERACFRDYQ RLGLGTVTAS
SSRSKTGEQF RVTAVNRLYS LCRSYPGLLV VPQSVQDSSL QKVARCYRHN RLPVVCWKHP
RTKAVLLRSG GFHGKSVVGL FKSQNQSSTA PANSSELSSS LEQEKYLQAI LNSIPIYFKL
NGSNTLSNRS LIGLSPVLGY RDKLFTHSNQ KPATKGIIQN QGVWASLRSS SRFSQHPSAA
DVGARLAGKD LAPPAGSESL HAQLLKQQAA LYIFGEKSHL RGFKLDSTLN CELVPVDFAD
TRQIKGAFKK LLRACAPSAT SSDIEDSFLK ALEDSEWILQ LHKLLQLALI LVELLDSGSS
VLLSLEDGWD ITTQVVSLVQ LLSDPFYRTL EGFQVLLEKE WLSFGHKFSQ RSNLTPSSQG
SGFTPIFLQF LDCVHQIQDQ CPLEFEFNQH YLKFLAYHYI SNRFKNFLLD SDYERLEHGT
LFEDKPGDKQ ARRGVCIWEC ISRMHRRSPL FFNYLYSPTE AEPVLKPSIS IPALRMWDFF
TGETLCTGPS YDWRMLAVRS ESMEETDTIA TSKRRIVWPC YSSVGRAQPD AITKLLADIE
RLEGEMSQAP ERWQATLEMV RVSIQEDLKQ EGNLRKQSAS TSGLIPTSSL QAFQRRSILH
LPDTGLGEDS SPTATNGVNR RAATLYNQFT PKNEENRSFE GILYKRGALL KGWKPRWFVL
DITKHQLRYY DTGEDTNCRG HIDLAEVESA LISTPTIGAP KHISEKAFFD LKTTKRVYNF
CASDAQSAHQ WMDKIQSCIS DA
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