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Database: UniProt
Entry: A0A1S3PT57_SALSA
LinkDB: A0A1S3PT57_SALSA
Original site: A0A1S3PT57_SALSA 
ID   A0A1S3PT57_SALSA        Unreviewed;      4898 AA.
AC   A0A1S3PT57;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 3-like isoform X5 {ECO:0000313|RefSeq:XP_014030872.1};
GN   Name=LOC106587081 {ECO:0000313|RefSeq:XP_014030872.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030872.1};
RN   [1] {ECO:0000313|RefSeq:XP_014030872.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030872.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_014030872.1; XM_014175397.1.
DR   GeneID; 106587081; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014030872.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4227   4249       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4439   4459       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4507   4526       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4650   4675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4698   4720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4779   4802       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       98    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1207       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1277   1484       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3959   3985       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      451    471       {ECO:0000256|SAM:Coils}.
FT   COILED     2980   3000       {ECO:0000256|SAM:Coils}.
FT   COILED     3427   3447       {ECO:0000256|SAM:Coils}.
FT   COILED     3555   3575       {ECO:0000256|SAM:Coils}.
FT   COILED     4139   4162       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4898 AA;  555313 MW;  D035396EDD204269 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVACIHK ENRKFCLTAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE HSLSVRALQE MLAKTGQNSE GAAQGGGHRT LLYGHAILLR HSFSAMYLTC
     LKTSRSQTDK LSFDVGLQED STGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL
     HLSISNGNIQ VDASFMQTLW NVHPTCSGSN VEEGYLLGGH VLRLFHGHDE VLTIPGSDQS
     DEQQRIVNYE TGNAGAKARS LWRLEPLRIS WSGSHIPWGQ PFRLRHLTTG HYLSLTEERG
     VVLQDREKSD TSSTAFCFRA SKEKLESSPK RDIEGMGMAE IKYGDSICFV MHVATGLWLS
     YQAPDVKSSR LGPLKRRAFL HSEGHMDDGL TLQRCQHEES RAARIIRNTT RLFSHFIRDL
     DCLGGKNRAS VALPIEEVLQ TLYDLITYFQ LPDAELEHEE KQIMLRSLKN RQNLFKQEGM
     LTLVSCCIDR LNVYNSAAHF GECAGAEAGA SWKEILNLLY ELLAALIRGN RNNCTQFSNN
     LDWLVSKLER LESSSGILEV LHCILTESPE ALNIIQRGHI KSIISLLYKH GRNHKILDVL
     CSLCVCNGVA VRANQNLICD HLLPKRDLLL QTRLVNDVQS MRPNIFLGLS EGSAQYKKWY
     YELMIDQVDH FLTSDPSHLR VGWATNKGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWS
     GRISRAVASI NQHILTSEDV VSCCLDLGAP SISFRINGQP VQGMFENFNI DGLFFPVVSF
     SAGVKVRFLL GGRHGDFKFL PPSGYAPCYE ALLPKEKMKV EPVKEYKRDM EGVRDLLGTT
     QFMSQASFIP TPVETSQIVM PPYLEKVRDR LAENIHELWG MNKIELGWSY GKIRDDNKRQ
     HPCLVDFSKL PETEKNYNLQ MSTETLKTLL ALGCHVVQVN ANAEEDLKKI KLPKNYMMSN
     GYKPTPLELS DVKVTPGQEL LVEKLAENAH NVWAKDRIKQ GWTYGIQQDV KSKRNPRLVP
     YSLLDERTKK SNRDSLREAI RTLIGYGYNI EPPDQDGAGH VVERLSIDKI RFFRVERTYA
     VLTGKWYFEF EAVTGGDMRV GWARPGCKPD VELGTDELAF VFDGYKGHRL NMGSRFFGRC
     WQAGDVVGCM INMEDKSMIF TLNGEILITN KGSELCFADF ETEDGFIPVC SLGLSQVGRM
     NLGKDASTFK YYTMCGLQEG FEPFAVNMNR EVTMWFSKRL PTFFNVPKNN NHIMVTRIDG
     TIDSPPCLKV SHRTFGTQNS NGDMVYCRLS MPVEFHSFFK TSPVMDMNGV HEEHESLKLK
     HRHPLKSMRH SHDGIRGTDY SNITTYYYSV RVFAGQDPSC VWVGWVTPDY HYYSNHFNLS
     KNRTVTVTLG DERGRVHESV RRSNCYMVWG GDATSSGHSS SRSNVDLEIG CLIDLATGLV
     TFTVNGKELA TSYQVEPNTK LFPAVFVRPT SPNLFQFELA KIKNTMPLSA AIFKSEHKNP
     VPQCPPRLDV QTINSVLWSR MPNTFLKVET ARVSERHGWV VQCLEPLQML AVHIPEENRC
     VDIMELSEQE DLRMFHYHTL KLYCALCALG NTRVAHALCS HLDQSQLLYT IDNQYLSGML
     REGFYNVLIS VHLETAKEAR LMMNNEFIIP VTAETRSIRL FSDASKHHSP PGVGLSTSLK
     PRLNFYPPCF ISTKREQHLY SPQIPLDALK EKAITMLTEA VQGGGHHIRD PVGGSVEYQF
     VPILRLIGTL LTMGVLGSQD VHKILLLIDP NVFAEHHEEA AAAVMEATEK EGLTGAEEKA
     VEAGEEEAAK EAKQPIKGLL EKRLPEPVKR QMCELLHYFC DCELKHRIEA IVSFSDSFVS
     KLQYNQKFRY NELMLALNMS AAVTAKKTKE FRSPPQEQIN MLLNFSTGED CPCPEDIQEE
     LYAFHNELRL HCGIPMEEED EEQDRSIKGR LLALVYKIKG QPLKTEEEPT EQEQQAPSNL
     KELISQTMVS WAQECHVQDP ELVRVMFSLL RRQYDSIGEL LRAMRKSYTI SAASIQDTIN
     LLASLGQIRS LLSVRMGKEE EKLMIDGLGD IMNNKIFYQH PNLMRVLGMH ETVMEVMVNV
     LGGGKSQEIA FPKMVASCCR FLCYFCRISR QNQKAMFDHL SYLLENSSVG LASPAMRGST
     PLDVAASSVM DNNGLALALE EPDLDKVVTY LAGCGLQSCP MLLDKGYPDI GWNPIEGERY
     LSFLRFAVFV NGESVEENSS VVVKLLIRRP ECFGPALRGE GGNGLLAAMK EAIKISDNPA
     VDLPSSAQGV SSDASAEDDE EEEVVHMGNA IMSFYSALID LLGRCAPEMH LINKGKGEAL
     RIRAILRSLV PTEDLVGIIS IPLKMPVVHK DGTVTEPDMA ASFCPDHKAP MVLFLDRVYG
     IEDQSFLLQL LDVGFLPDLQ ASASLDTEVL STTETALAMN RYIGSAMLPL LTRCAPHFAG
     TEHYAVLIDS TLHTIYRLSK GRSLTKAQRD AIEECLLAVC KYLRPSMLQH LLRRLVFDVP
     LLTEYCKMPL RLLTNHYEQS WKYYCLPSGW GSYGMASDEE LLLTKKIFWG VLDSLSQRKY
     DADLFKMAMP CLSAISGALP PDYIDATIST TLEKPVSVDA QGNFDPKPIS TANISLPEKL
     EHVANKYAEH SHDKWSAEKV MLGWRYGDCI DEKAKTHPLL RTYKGLTEKE KDIYRWPVRE
     TLKTMLAMGW NIDRTKDGET MSLRESEKMR KISQSSSHAN GFNPTPIDTI NVVLSRELQG
     MVEVVAENYH NIWAKKKKND LGIRGGATHP LLVPYDTLTA KEKARDKEKA QDLFRFLQIN
     GYAITRGLKD MEQDSSSMEK RFAYKFLKKL LKYVNSAQEF IAHLEVMATS GKTDKSPHEQ
     EIKFFAKVLL PLIDQYFKNH CLYFLSSPSK NLSSSGYASN KEKEMVTSLF CKLAALVRHR
     ISLFGSDSTT MVSVLHILAH TLDTRTVMKS GSELVKAGLR TFFENAAEDL EKTLENLKLG
     KFTHSRSQMK GVSQNINYTT VALLPILTAL FEHITQHHFG VDLLLDDVQV SCYRILTSLY
     ALGTGKNIYV ERQLPALGEC LATLAGAMPV AFLEPLLNKH NPCSVFNTKT ARERAILGMP
     DAVEEMCPEM PRLDVLMKDI NDMSESGARY TEMPHVIEVV LPMLCNYLSY WWEKGPENQE
     SPHSGGSVGG SVFSTTVTSE HLSLILGNIL KILNSNLGID EASWMKRIAV YAQPIITKAR
     AVLLKSHFLP TLEKLKKKTV KVVTEEELLK ADSKGDTQEA ELLILDEFAV LCRDLYAFYP
     MLIRYVDNNR SRWLKEPDAD SNELFRMVAE IFILWCKSHN FKREEQNFVV QNEINNLSFL
     TGDSKIKMSK SGGQDQERKH KRKRGEFYSI QTSLIVAALK KMLPIGLNMC TPGDQELISL
     AKTRYILKDT DDEVKEHLRQ NLHLQEKSED PAVRWQLNLY KDVMVKNEGP PDPERTVFRV
     QSISAAVFHL EQVEQPLRSK KCVWQKLLSK QRKRAVVACF RMAPLYNLPR HKSNNYFLNA
     YRRYWLEKMH ENTDYDSLLS MLTKTQLKVE EEEEEEAEMQ PDPLHQLILH FSHNALTERS
     SLEEDPLYIA YADMMAKSCA EDEEEEDEEG KEKTFEEKEM EKQKTLYQQA RLHDRGAAEM
     VLQMISASRG SLGPMVTFTL KLGISILNGG NILVQQKMLD YLKEKRDAGF FKSLSGLMQS
     CSVLDLNAFE RQNKAEGLGM VTEEGSINVS ERGSKVLQND EFTKDLFRFL QLLCEGHNND
     FQNFLRTQTG NTTTVNIIIS TVDYLLRLQE SISDFYWYYS GKDIMDEAGQ RNFSKALAVA
     KQIFNSLTEY IQGPCIGNQQ SLAHSRLWDA VVGFLHVFAN MQMKLSQDSS QIDLLKELLD
     LQKDMIVMML SLLEGNVVNG TIGKQMVDTL VESSSNVEMI LKFFDMFLKL KDLTSSDNFK
     EYDPDSKGVI SKKEFQKSME NQKQYSQSEI EFLLSCVEAD ENDMFNYEEF VERFHEPAKD
     IGFNVAVLLT NLSEHMPHDA RLATFLDLAE SVINYFEPYL GRIEIMGGAK RIERVYFEIS
     ESSRTQWEKP QVKESKRQFI FDVVNEGGES EKMELFVNFC EDTIFEMQLA SQISEPDSVE
     RLEEEEEDSQ SVEEEEEEEE EESMMESHSA FTNSCVSMRK NLSSFRQLLT FKSMRRQYRN
     FRKMSVREMV RGLFSFFWKI ITGLFRFLYN LVWGFFHILW SSMFGGGLVE GAKNMKVTDI
     LGNMPDPTQF GIHGDVLEAE KMEASEASSV AEMVQMAQGD KAEADLMAEL LNIQTKSQGG
     KHAAEPGLGD MGEVVGVDAP SLASAVKQKK AKEAATMEPA NGDHKAEPEK ADPEDEEKKD
     KDKAKEETPP ESPPEEEKKA PKKRPGLKKE PPEAFMARFF SGLEIYQTKM LNYLARNFYN
     LRFLALFVAF AINFILLFYK VTGDDGDDDD PDPWNGGGGT DEEDDEGGME YFVLQESTGY
     MAPTLRFLAI LHTVISFLCV VGYYYLKVPL TVFKREKEIA RKLEFDGLYI TEQPSDDDIK
     GQWDRLVINT PSFPNNYWDK FVKRKVINKY GDLYGAERIA ELLGLDKSAL DFNPTEETVL
     KEASLVSWLS SVDTKYQCWK MGVVFTDNSF LYLVWYTTMS ILGHYNNFFF AAHLLDIAMG
     FKTLRTILSS VTHNGKQLVL TVGLLAVVVY LYTVVAFNFF RKFYNKSEDE NQPDMKCDDM
     MTCYLFHMYV GVRAGGGIGD EIEDPAGDPY ELYRILFDIT FFFFVIVILL AIIQGLIIDA
     FGELRDQQEQ VKEDMETKCF ICGIGNDYFD TTPHGFETHT LQEHNLANYL FFLMYLINKD
     ETEHTGQESY VWKMYQERQW DFFPAGDCFR KQYEDQLG
//
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