ID A0A1S3PTH9_SALSA Unreviewed; 1637 AA.
AC A0A1S3PTH9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=MAP kinase-activating death domain protein {ECO:0000256|ARBA:ARBA00017868};
GN Name=madd {ECO:0000313|RefSeq:XP_014030519.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030519.1};
RN [1] {ECO:0000313|RefSeq:XP_014030519.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030519.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the MADD family.
CC {ECO:0000256|ARBA:ARBA00005978}.
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DR RefSeq; XP_014030519.1; XM_014175044.1.
DR GeneID; 106587089; -.
DR OrthoDB; 24616at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.30.450.200; -; 1.
DR Gene3D; 3.40.50.11500; -; 1.
DR InterPro; IPR001194; cDENN_dom.
DR InterPro; IPR005112; dDENN_dom.
DR InterPro; IPR043153; DENN_C.
DR InterPro; IPR039980; MADD.
DR InterPro; IPR037516; Tripartite_DENN.
DR InterPro; IPR005113; uDENN_dom.
DR PANTHER; PTHR13008:SF7; MAP KINASE-ACTIVATING DEATH DOMAIN PROTEIN; 1.
DR PANTHER; PTHR13008; MAP-KINASE ACTIVATING DEATH DOMAIN PROTEIN MADD /DENN/AEX-3 C.ELEGANS; 1.
DR Pfam; PF02141; DENN; 1.
DR Pfam; PF03456; uDENN; 1.
DR SMART; SM00801; dDENN; 1.
DR SMART; SM00799; DENN; 1.
DR SMART; SM00800; uDENN; 1.
DR PROSITE; PS50211; DENN; 1.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Kinase {ECO:0000313|RefSeq:XP_014030519.1};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000313|RefSeq:XP_014030519.1}.
FT DOMAIN 13..595
FT /note="UDENN"
FT /evidence="ECO:0000259|PROSITE:PS50211"
FT REGION 103..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..666
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..983
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..154
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..657
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..756
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 776..794
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 829..845
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 860..876
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 961..983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1173..1206
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1207..1263
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1280..1304
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1637 AA; 180631 MW; 42F03C162535406D CRC64;
MEKKKMCPRL LDYLVVVGAR QPSTDTGSQT PQLLRRYPLE DHPDFPLSPD VVFFCQPEGC
QSIRQRRVSL RDDASFVFAL TDKDSGITRY GVCVNFYRSF QRGGHRRDKA GSGGTAAQTA
EATSEGSDGS GGCPTASTLP TPASADTTAT SAPGTEPGPP GGEPNAGRSP RHKRSTAKMV
NRNRDSTLTS LCMISHYPFF STFRECLYIL KRMVDCCSHR LTQRAGLPRA TQRDTMWRVF
TGALLVEEKG SQLLADLREI ESWVYRLLRS PVPVAGQRRV DVEVLPHEMQ PALTFALPDN
SRFSMVDFPL HLPLELLGVD ACLMVLSCIL LEHKVVLQSR DYNALTMSVM AFVAMIYPLE
YMFPVIPLLP TCMASAEQLL LAPTPYIIGV PASFFLYKSD FKMPDDIWLV DLDCNKVKAP
TNAEHLPPLP EPESTELKKH LKQCLVRLTV ITQKQIFSSD NKALASMSLN TQPILNLEKF
QEGQELPLLP PGQNKASPSS TEFNPLIYGN DVDSVDVATR VAMVRFFNSP NVLQGFQMHT
RTLRLFPRPV VAFQATSFLA SRPRRSGFAE KLSHTQAVEY YGEWALNPTN LAFQRIHNNV
YDPSLIGDKG KWYAHQLQPV FYRVYDGSSQ LAEAMSGPLE DEANDSDPTD DSSDSEAGYD
DSSSSYSSLG DLVNEMIKCD IQGDMPNLDP PTHAALGDAS EVEFQEFKGE GLLPQEKALP
EGGDGAPEPP DGQTLRSSSS TTASSSPSTI IQGVNNEQAE PVEMEALASA ALQNPVPGPG
APPFSRPPPD AAPVGPANKK GEYDNPYFEP QYGFPAEEDP EAEDQEETYT PRFNQNLNGN
KAQRPLRPSS LKLPGESDGE GDSRNSSPNS TISNNSSDGF GGLMSFASNL YKNHGTSFSL
SNLSVPNKGG LREKAAGAGP FPNLKVFGLN SLMEIITEAG PGSGEGGARG PPRALVDQKS
SVIKHSPTVK RDSPSPQGRA NNTSENQQFL KEVVQSVLEG QGVGWLNMKK VRRLLENEQL
RVFVLSKLNR AVQSEEDVRQ EVIRDVEISR KVYKGMLDIL KCTVSSLEHS YTNAGLGGMA
SVFVLLEIAR THYQTKVDPE KRKRSPSDAA SSPGSKGSPS PRMEGTKPPG LLLVPRLQLP
HPTSGGKGTR HFDTRSLNEE NFIASIELWS RHHEKDKQKA MEKQQRAEGA KKQHPELTDT
EEKKSQISAD SGLSITSGSQ KSDTESVTST EPPVLTRSTS QDSEASTVIS NSSGETLGAD
SDLSSTAGEG LGGRQAPHLN LSRGTLSDSE IETNPATSSV FGKTQKMKPG VKEAKAKLVP
VLAKGPPAQP LEDISMRIYL CDGLLGRDKS SMWDQLEDAA METFSLSKER STLWDQVQFW
EDAYLDAVML EREGMGMDQG PQEMIDRYLS LGDHDRKRLE DDEDRLLATL LHNMIAYMLM
VKVNKNDIRK KVRRLMGKSH IGLSHSQEIN ECLDKLANLN GRELSIRPSG SRHIKKQTFV
VHAGTDTTGD IFFMEVCDDC IVLRSNIGTV YERWWYEKLI NMTYCPKTKV LCLWRRNGQE
TQLNKFYTKK CRELYYCVKD SMERAAARQQ SIKPGPELGG EFPVQDMKTG EGGLLQVTLE
GINLKFMHSQ FLKLKKW
//
