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Database: UniProt
Entry: A0A1S3PU27_SALSA
LinkDB: A0A1S3PU27_SALSA
Original site: A0A1S3PU27_SALSA 
ID   A0A1S3PU27_SALSA        Unreviewed;      4896 AA.
AC   A0A1S3PU27;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 3-like isoform X9 {ECO:0000313|RefSeq:XP_014031193.1};
GN   Name=LOC106587081 {ECO:0000313|RefSeq:XP_014031193.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014031193.1};
RN   [1] {ECO:0000313|RefSeq:XP_014031193.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014031193.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   RefSeq; XP_014031193.1; XM_014175718.1.
DR   GeneID; 106587081; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014031193.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4225   4247       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4437   4457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4505   4524       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4648   4673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4696   4718       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4777   4800       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      103    158       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      165    210       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      218    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    335       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      343    400       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1212       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1282   1489       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3957   3983       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      456    476       {ECO:0000256|SAM:Coils}.
FT   COILED     2985   3005       {ECO:0000256|SAM:Coils}.
FT   COILED     3432   3452       {ECO:0000256|SAM:Coils}.
FT   COILED     3559   3584       {ECO:0000256|SAM:Coils}.
FT   COILED     4137   4160       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4896 AA;  555070 MW;  D5E42A72B08E1920 CRC64;
     MAEGGEGEDE IQFLRTDDEV VLQCVACIHK ENRKFCLTAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE HSLSVRALQE MLAKTGQNSE GRLIRKAAQG GGHRTLLYGH AILLRHSFSA
     MYLTCLKTSR SQTDKLSFDV GLQEDSTGEA CWWTIHPASK QRSEGEKVRI GDDLILVSVS
     SERYLHLSIS NGNIQVDASF MQTLWNVHPT CSGSNVEEGY LLGGHVLRLF HGHDEVLTIP
     GSDQSDEQQR IVNYETGNAG AKARSLWRLE PLRISWSGSH IPWGQPFRLR HLTTGHYLSL
     TEERGVVLQD REKSDTSSTA FCFRASKEKL ESSPKRDIEG MGMAEIKYGD SICFVMHVAT
     GLWLSYQAPD VKSSRLGPLK RRAFLHSEGH MDDGLTLQRC QHEESRAARI IRNTTRLFSH
     FIRDLDCLGG KNRASVALPI EEVLQTLYDL ITYFQLPDAE LEHEEKQIML RSLKNRQNLF
     KQEGMLTLVS CCIDRLNVYN SAAHFGECAG AEAGASWKEI LNLLYELLAA LIRGNRNNCT
     QFSNNLDWLV SKLERLESSS GILEVLHCIL TESPEALNII QRGHIKSIIS LLYKHGRNHK
     ILDVLCSLCV CNGVAVRANQ NLICDHLLPK RDLLLQTRLV NDVQSMRPNI FLGLSEGSAQ
     YKKWYYELMI DQVDHFLTSD PSHLRVGWAT NKGYAPYPGG GEGWGGNGVG DDLYSYGFDG
     LHLWSGRISR AVASINQHIL TSEDVVSCCL DLGAPSISFR INGQPVQGMF ENFNIDGLFF
     PVVSFSAGVK VRFLLGGRHG DFKFLPPSGY APCYEALLPK EKMKVEPVKE YKRDMEGVRD
     LLGTTQFMSQ ASFIPTPVET SQIVMPPYLE KVRDRLAENI HELWGMNKIE LGWSYGKIRD
     DNKRQHPCLV DFSKLPETEK NYNLQMSTET LKTLLALGCH VVQVNANAEE DLKKIKLPKN
     YMMSNGYKPT PLELSDVKVT PGQELLVEKL AENAHNVWAK DRIKQGWTYG IQQDVKSKRN
     PRLVPYSLLD ERTKKSNRDS LREAIRTLIG YGYNIEPPDQ DGAGHVVERL SIDKIRFFRV
     ERTYAVLTGK WYFEFEAVTG GDMRVGWARP GCKPDVELGT DELAFVFDGY KGHRLNMGSR
     FFGRCWQAGD VVGCMINMED KSMIFTLNGE ILITNKGSEL CFADFETEDG FIPVCSLGLS
     QVGRMNLGKD ASTFKYYTMC GLQEGFEPFA VNMNREVTMW FSKRLPTFFN VPKNNNHIMV
     TRIDGTIDSP PCLKVSHRTF GTQNSNGDMV YCRLSMPVEF HSFFKTSPVM DMNGVHEEHE
     SLKLKHRHPL KSMRHSHDGI RGTDYSNITT YYYSVRVFAG QDPSCVWVGW VTPDYHYYSN
     HFNLSKNRTV TVTLGDERGR VHESVRRSNC YMVWGGDATS SGHSSSRSNV DLEIGCLIDL
     ATGLVTFTVN GKELATSYQV EPNTKLFPAV FVRPTSPNLF QFELAKIKNT MPLSAAIFKS
     EHKNPVPQCP PRLDVQTINS VLWSRMPNTF LKVETARVSE RHGWVVQCLE PLQMLAVHIP
     EENRCVDIME LSEQEDLRMF HYHTLKLYCA LCALGNTRVA HALCSHLDQS QLLYTIDNQY
     LSGMLREGFY NVLISVHLET AKEARLMMNN EFIIPVTAET RSIRLFSDAS KHHSPPGVGL
     STSLKPRLNF YPPCFISTKR EQHLYSPQIP LDALKEKAIT MLTEAVQGGG HHIRDPVGGS
     VEYQFVPILR LIGTLLTMGV LGSQDVHKIL LLIDPNVFAE HHEEAAAAVM EATEKEGLTG
     AEEKAVEAGE EEAAKEAKQP IKGLLEKRLP EPVKRQMCEL LHYFCDCELK HRIEAIVSFS
     DSFVSKLQYN QKFRYNELML ALNMSAAVTA KKTKEFRSPP QEQINMLLNF STGEDCPCPE
     DIQEELYAFH NELRLHCGIP MEEEDEEQDR SIKGRLLALV YKIKGQPLKT EEEPTEQEQQ
     APSNLKELIS QTMVSWAQEC HVQDPELVRV MFSLLRRQYD SIGELLRAMR KSYTISAASI
     QDTINLLASL GQIRSLLSVR MGKEEEKLMI DGLGDIMNNK IFYQHPNLMR VLGMHETVME
     VMVNVLGGGK SQEIAFPKMV ASCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA
     MRGSTPLDVA ASSVMDNNGL ALALEEPDLD KVVTYLAGCG LQSCPMLLDK GYPDIGWNPI
     EGERYLSFLR FAVFVNGESV EENSSVVVKL LIRRPECFGP ALRGEGGNGL LAAMKEAIKI
     SDNPAVDLPS SAQGVSSDAS AEDDEEEEVV HMGNAIMSFY SALIDLLGRC APEMHLINKG
     KGEALRIRAI LRSLVPTEDL VGIISIPLKM PVVHKDGTVT EPDMAASFCP DHKAPMVLFL
     DRVYGIEDQS FLLQLLDVGF LPDLQASASL DTEVLSTTET ALAMNRYIGS AMLPLLTRCA
     PHFAGTEHYA VLIDSTLHTI YRLSKGRSLT KAQRDAIEEC LLAVCKYLRP SMLQHLLRRL
     VFDVPLLTEY CKMPLRLLTN HYEQSWKYYC LPSGWGSYGM ASDEELLLTK KIFWGVLDSL
     SQRKYDADLF KMAMPCLSAI SGALPPDYID ATISTTLEKP VSVDAQGNFD PKPISTANIS
     LPEKLEHVAN KYAEHSHDKW SAEKVMLGWR YGDCIDEKAK THPLLRTYKG LTEKEKDIYR
     WPVRETLKTM LAMGWNIDRT KDGETMSLRE SEKMRKISQS SSHANGFNPT PIDTINVVLS
     RELQGMVEVV AENYHNIWAK KKKNDLGIRG GATHPLLVPY DTLTAKEKAR DKEKAQDLFR
     FLQINGYAIT RGLKDMEQDS SSMEKRFAYK FLKKLLKYVN SAQEFIAHLE VMATSGKTDK
     SPHEQEIKFF AKVLLPLIDQ YFKNHCLYFL SSPSKNLSSS GYASNKEKEM VTSLFCKLAA
     LVRHRISLFG SDSTTMVSVL HILAHTLDTR TVMKSGSELV KAGLRTFFEN AAEDLEKTLE
     NLKLGKFTHS RSQMKGVSQN INYTTVALLP ILTALFEHIT QHHFGVDLLL DDVQVSCYRI
     LTSLYALGTG KNIYVERQLP ALGECLATLA GAMPVAFLEP LLNKHNPCSV FNTKTARERA
     ILGMPDAVEE MCPEMPRLDV LMKDINDMSE SGARYTEMPH VIEVVLPMLC NYLSYWWEKG
     PENQESPHSG GSVGGSVFST TVTSEHLSLI LGNILKILNS NLGIDEASWM KRIAVYAQPI
     ITKARAVLLK SHFLPTLEKL KKKTVKVVTE EELLKADSKG DTQEAELLIL DEFAVLCRDL
     YAFYPMLIRY VDNNRSRWLK EPDADSNELF RMVAEIFILW CKSHNFKREE QNFVVQNEIN
     NLSFLTGDSK IKMSKSGGQD QERKHKRKRG EFYSIQTSLI VAALKKMLPI GLNMCTPGDQ
     ELISLAKTRY ILKDTDDEVK EHLRQNLHLQ EKSEDPAVRW QLNLYKDVMV KNEGPPDPER
     TVFRVQSISA AVFHLEQVEQ PLRSKKCVWQ KLLSKQRKRA VVACFRMAPL YNLPRHRSIN
     LFLLGYQRIW IETETYSFEE KLVQDLAKTQ LKVEEEEEEE AEMQPDPLHQ LILHFSHNAL
     TERSSLEEDP LYIAYADMMA KSCAEDEEEE DEEGKEKTFE EKEMEKQKTL YQQARLHDRG
     AAEMVLQMIS ASRGSLGPMV TFTLKLGISI LNGGNILVQQ KMLDYLKEKR DAGFFKSLSG
     LMQSCSVLDL NAFERQNKAE GLGMVTEEGS SSKVLQNDEF TKDLFRFLQL LCEGHNNDFQ
     NFLRTQTGNT TTVNIIISTV DYLLRLQESI SDFYWYYSGK DIMDEAGQRN FSKALAVAKQ
     IFNSLTEYIQ GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI DLLKELLDLQ
     KDMIVMMLSL LEGNVVNGTI GKQMVDTLVE SSSNVEMILK FFDMFLKLKD LTSSDNFKEY
     DPDSKGVISK KEFQKSMENQ KQYSQSEIEF LLSCVEADEN DMFNYEEFVE RFHEPAKDIG
     FNVAVLLTNL SEHMPHDARL ATFLDLAESV INYFEPYLGR IEIMGGAKRI ERVYFEISES
     SRTQWEKPQV KESKRQFIFD VVNEGGESEK MELFVNFCED TIFEMQLASQ ISEPDSVERL
     EEEEEDSQSV EEEEEEEEEE SMMESHSAFT NSCVSMRKNL SSFRQLLTFK SMRRQYRNFR
     KMSVREMVRG LFSFFWKIIT GLFRFLYNLV WGFFHILWSS MFGGGLVEGA KNMKVTDILG
     NMPDPTQFGI HGDVLEAEKM EASEASSVAE MVQMAQGDKA EADLMAELLN IQTKSQGGKH
     AAEPGLGDMG EVVGVDAPSL ASAVKQKKAK EAATMEPANG DHKAEPEKAD PEDEEKKDKD
     KAKEETPPES PPEEEKKAPK KRPGLKKEPP EAFMARFFSG LEIYQTKMLN YLARNFYNLR
     FLALFVAFAI NFILLFYKVT GDDGDDDDPD PWNGGGGTDE EDDEGGMEYF VLQESTGYMA
     PTLRFLAILH TVISFLCVVG YYYLKVPLTV FKREKEIARK LEFDGLYITE QPSDDDIKGQ
     WDRLVINTPS FPNNYWDKFV KRKVINKYGD LYGAERIAEL LGLDKSALDF NPTEETVLKE
     ASLVSWLSSV DTKYQCWKMG VVFTDNSFLY LVWYTTMSIL GHYNNFFFAA HLLDIAMGFK
     TLRTILSSVT HNGKQLVLTV GLLAVVVYLY TVVAFNFFRK FYNKSEDENQ PDMKCDDMMT
     CYLFHMYVGV RAGGGIGDEI EDPAGDPYEL YRILFDITFF FFVIVILLAI IQGLIIDAFG
     ELRDQQEQVK EDMETKCFIC GIGNDYFDTT PHGFETHTLQ EHNLANYLFF LMYLINKDET
     EHTGQESYVW KMYQERQWDF FPAGDCFRKQ YEDQLG
//
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