ID A0A1S3PUB4_SALSA Unreviewed; 177 AA.
AC A0A1S3PUB4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Pro-adrenomedullin {ECO:0000256|ARBA:ARBA00023472};
GN Name=LOC106587204 {ECO:0000313|RefSeq:XP_014030814.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014030814.1};
RN [1] {ECO:0000313|RefSeq:XP_014030814.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014030814.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the adrenomedullin family.
CC {ECO:0000256|ARBA:ARBA00010575}.
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DR RefSeq; XP_014030814.1; XM_014175339.1.
DR AlphaFoldDB; A0A1S3PUB4; -.
DR STRING; 8030.ENSSSAP00000095250; -.
DR PaxDb; 8030-ENSSSAP00000095250; -.
DR Ensembl; ENSSSAT00000129580; ENSSSAP00000095254; ENSSSAG00000072685.
DR GeneID; 106587204; -.
DR KEGG; sasa:106587204; -.
DR OMA; QSFLYCC; -.
DR OrthoDB; 4548241at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR Bgee; ENSSSAG00000072685; Expressed in mesonephros and 13 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR InterPro; IPR021116; Calcitonin/adrenomedullin.
DR InterPro; IPR001710; Pro-ADM.
DR PANTHER; PTHR23414; ADRENOMEDULLIN, ADM; 1.
DR PANTHER; PTHR23414:SF3; PRO-ADRENOMEDULLIN; 1.
DR Pfam; PF00214; Calc_CGRP_IAPP; 1.
DR PRINTS; PR00801; ADRENOMEDULN.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR621116-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..177
FT /note="Pro-adrenomedullin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010273685"
FT DISULFID 99..104
FT /evidence="ECO:0000256|PIRSR:PIRSR621116-50"
SQ SEQUENCE 177 AA; 20091 MW; ACEF34DBE59D7342 CRC64;
MKLILQSFLY GCLLATIAQS VAGFKLEISP ELKKRLSIWM QSRSRRDLNS FSAERIAESV
QFVSPEDVRD TLIPHSSTDI SVRTKRSKNS VNQAWRPGCS LGTCTVHDLA HRIHQLNNKL
KIGSAPIDKI SPQGYGRRRR SLPERRATLR LEGGRLKPVW GNADSHVHKL EELLRRT
//
