ID A0A1S3PUH9_SALSA Unreviewed; 816 AA.
AC A0A1S3PUH9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Spondin-1 {ECO:0000256|ARBA:ARBA00019594};
DE AltName: Full=F-spondin {ECO:0000256|ARBA:ARBA00030964};
GN Name=LOC106587461 {ECO:0000313|RefSeq:XP_014031348.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014031348.1};
RN [1] {ECO:0000313|RefSeq:XP_014031348.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014031348.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR RefSeq; XP_014031348.1; XM_014175873.1.
DR AlphaFoldDB; A0A1S3PUH9; -.
DR STRING; 8030.ENSSSAP00000061528; -.
DR PaxDb; 8030-ENSSSAP00000061528; -.
DR GeneID; 106587461; -.
DR OrthoDB; 5404502at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd08544; Reeler; 1.
DR Gene3D; 2.60.40.2130; F-spondin domain; 1.
DR Gene3D; 2.60.40.4060; Reeler domain; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 6.
DR InterPro; IPR002861; Reeler_dom.
DR InterPro; IPR042307; Reeler_sf.
DR InterPro; IPR009465; Spondin_N.
DR InterPro; IPR038678; Spondin_N_sf.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR044004; TSP1_spondin_dom.
DR NCBIfam; NF038123; NF038123_dom; 1.
DR PANTHER; PTHR11311; SPONDIN; 1.
DR PANTHER; PTHR11311:SF16; SPONDIN-1; 1.
DR Pfam; PF02014; Reeler; 1.
DR Pfam; PF06468; Spond_N; 1.
DR Pfam; PF19028; TSP1_spondin; 1.
DR Pfam; PF00090; TSP_1; 5.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 6.
DR PROSITE; PS51019; REELIN; 1.
DR PROSITE; PS51020; SPONDIN; 1.
DR PROSITE; PS50092; TSP1; 6.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..816
FT /note="Spondin-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010310207"
FT DOMAIN 28..194
FT /note="Reelin"
FT /evidence="ECO:0000259|PROSITE:PS51019"
FT DOMAIN 194..387
FT /note="Spondin"
FT /evidence="ECO:0000259|PROSITE:PS51020"
FT REGION 720..765
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 727..750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 91625 MW; F20DFF2697474BAD CRC64;
MAGAGIFLCI LLLQCFISSA LCNAGFAFTE EPSERAGKSD GYCSRILRAQ GTRKEGYNEF
RLRVEGDPEN YQPGSTYRVT LYASSPAYFR GFTLIALREG REGDKEEDYA GNFQIIDEED
TQFMINCPPA VTESTPRRRT RIQVFWTAPP SSSGCLTLKA SIVQKRIIYF QDEGSLTKRM
CEKESLYGET TEKPLLDCCA CGTAKYRVTF YGNWSEKVHP KDYPRRANHW SAIIGASHSK
NYVLWEYGGY ASEGIKKVAE LGSPVSMEEE IRQKGDDVLT VIKMKAQWPA WQPLNVRAAP
SAEFSVDRTR HLMSFLTMLG PSPDWNVGLS AEDLCTKECG WAQRVVQDMI PWDAGTDNGV
TYESPNKPTV PQEKIRPLTS LDHPQSPFYD PEGGAITPVA RVVVERIARK GEQCNIVPDN
VDDIVADIAQ EEKEEDDTPE TCIYSNWSPW SACSSATCDK GKRMRQRMLK AQLDLSVPCP
HTQDFEPCMG PGCSDEEGST CTMSEWITWS PCSMSCGMGL RSRERYVKQF PDDGSVCTLP
TEENEKCIVN EECTLNSCLV TEWGEWDSCS ATCGLGMKRR ERMVKMPPPD GSICGAEVLE
VEKCMMPECH TIPCMLSPWS DWSDCSVTCG KGMRTRQRVL KSPVELGECT EDLEQVEKCM
LPECPTDCMV SEWTEWSECN KSCGKGHMIR TRMVKLEPQF GGDSCPETVQ RKKCKIRKCN
RGGGHGQVNS DEKKRRKEAR EKRRSKQGGR QGEETTSTAE HPGCKMRPWS SWTDCTKLCG
GGIQERLMTA KRRLKSAQLP SCKDRKEIRA CNVHPC
//
