ID A0A1S3PVF7_SALSA Unreviewed; 358 AA.
AC A0A1S3PVF7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Insulin gene enhancer protein ISL-3 isoform X4 {ECO:0000313|RefSeq:XP_014031683.1};
GN Name=LOC106587637 {ECO:0000313|RefSeq:XP_014031683.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014031683.1};
RN [1] {ECO:0000313|RefSeq:XP_014031683.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014031683.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014031683.1; XM_014176208.1.
DR AlphaFoldDB; A0A1S3PVF7; -.
DR GeneID; 106587637; -.
DR OrthoDB; 2880952at2759; -.
DR Proteomes; UP000087266; Chromosome ssa26.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048665; P:neuron fate specification; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR CDD; cd09366; LIM1_Isl; 1.
DR CDD; cd09374; LIM2_Isl; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 2.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR047169; ISL1/2-like.
DR InterPro; IPR047244; ISL1/2-like_LIM1.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24204; INSULIN GENE ENHANCER PROTEIN; 1.
DR PANTHER; PTHR24204:SF2; INSULIN GENE ENHANCER PROTEIN ISL-2; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00389; HOX; 1.
DR SMART; SM00132; LIM; 2.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 25..87
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 88..149
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 188..248
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 190..249
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 325..358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 358 AA; 40230 MW; 12ADBB5D63952BB7 CRC64;
MVDIIFNSSF LGDMGDHSKK KSGFAMCVGC GSQIHDQYIL RVSPDLEWHA ACLKCAECSQ
YLDETCTCFV RDGKTYCKRD YVRLFGIKCA KCNLGFSSSD LVMRARDNVY HIECFRCSVC
SRQLLPGDEF SLRDEELLCR ADHSLLMERS SAGSPISPGH IHSNRSLHLA EPVTVRAPHR
NHVHKQSEKT TRVRTVLNEK QLHTLRTCYN ANPRPDALMK EQLVEMTGLS PRVIRVWFQN
KRCKDKKRSI LMKQLQQQQH SDKTSLQGLT GTPLVARSPI RHDNTVQGNS VEVQTYQPPW
KALSEFALQS DLDQPAFQQL VSFSESGSLG NSSGSDVTSL SSHLPDTPNS MVPSPVET
//
