ID A0A1S3PXI2_SALSA Unreviewed; 2390 AA.
AC A0A1S3PXI2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Histone-lysine N-methyltransferase ASH1L-like isoform X4 {ECO:0000313|RefSeq:XP_014032392.1};
GN Name=LOC106588182 {ECO:0000313|RefSeq:XP_014032392.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014032392.1};
RN [1] {ECO:0000313|RefSeq:XP_014032392.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014032392.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014032392.1; XM_014176917.1.
DR OrthoDB; 2882778at2759; -.
DR Proteomes; UP000087266; Chromosome ssa27.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR CDD; cd19174; SET_ASH1L; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR46147; HISTONE-LYSINE N-METHYLTRANSFERASE ASH1; 1.
DR PANTHER; PTHR46147:SF2; SET-BINDING PROTEIN; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00384; AT_hook; 5.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2021..2072
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 2075..2191
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2199..2215
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..793
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 979..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1115..1189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1359..1398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1445..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1569..1709
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1750..1866
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..1922
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..74
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..177
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..262
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..332
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 390..482
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 483..516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 541..563
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 574..595
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 640..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 671..685
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 728..742
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..904
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 905..944
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 998..1019
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1039..1070
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1174..1189
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1360..1374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1447..1464
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1522
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1591..1606
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1651..1666
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1773..1787
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2390 AA; 260984 MW; 10B53D277BA1C10B CRC64;
MDQRTQGGPA TPPPLLTTAP PGEREKEGGG GKKDEEEEKK EEREGSQRDS SSAAGGGGGS
GEQQPPQFSV KETSLHEGNV KLKIGLQAKR MKKPPKILEN YVCRPAFRAT VRPSGRGGGR
GSRGGVGTGD GGNQTQSPPH GREREQSPGM NRPIPLSSSP SAAAPTPPPP VPAPSTTSPS
PVNGSTPAKR GLPKLACKSD KFEAKLDGKS AASTERPLNL HRPLTDGKTH HASGKKTPTP
QTKSPTSLPS PPAPPSPEPS VEAATKPPGY TYSSEGLREK DRGVPSWGAP TVTEKLAQLI
ATCPPSKSTK VKPSKTTPSP TTHTTSNFMA PTPKQRDRAM ANRATYSRAV HLAPPPPVSR
PPGRPYGSRN NKDNVLEKSS TPPGKEEADG ASKSSSSNNS NSSRSSSPTL TYGGGNNRLA
TISKDINDSN SNGAKPLQSR LTHCPPPHSV SSSSASPPRL SSCSSSEKGT GSGPSRQGSP
ASQGHHSRDR DSSSQAEERE SSEREQVRDR DGPRDLTKCS LPSALGKQEA KDKGANQSLR
GERGKSLSPS KRSPNPIKRN PNPNKRSPNR ERDGHTSGTS SPPESVRRTA SPPETAGNHS
PPPLRDESPG DESPGSPPEQ ENKPLKKRRG RKPRWTRVVN RTQRAGQYSP VDQCETIMPL
SSSGLDTPPP IRRPVGRPPN PNKVKPPAVS QLFPQPARKR GRPKSKMPRL DAPTRGRPPH
KLAPSKVFSL HRSKEEQDPP VLHPEVDLNP PKPMPRKRGR PKRLPPTLPQ EGQPPTLAPE
AGDGKQFRTK GNGQLIMKTI IGKINKMKSV KRKRFLSQIL LGPGSGPEQE PPRGTASGVV
GQVAAATQSL SSLAASFGGK LGPQINVSKK GTIYMGKRRG RKPKAPTNPS LAAPTPPTEG
PFLSPNTTSP PHHHQSQPQH QLPSAEVFPS PSLSQSSGGQ SPISDSCFVA PGAVHFLTHP
HFHSHHSFPF PPPTFSAPSP RTLGPLGSSA AVASQKKSCR GYHHHHHHYR QHYHYRKLSP
PRPLHPTSPA PLSELKEATP SPVSESHSDE TVPSDSGIGT DNNSTSDRGE KAGGASGLGS
VGIPPGMASG LLMPGVMGSA VGLGVGLNPR GGLRHSSSVL LEHPSPSPSP LGARSSPDPR
RPHLATPPSA LVGHKEKHKH KCKRRSHGCP GYDKLKRQKR KRKKKYLQLR SRRQDPDFLA
ELDEIVVRLS EIRIAHRTPA LRLGSGLGMP PGSAGAGRVP GAVGRATGAI GGAGGPPPHH
YLHRDLLPTI FRINFSGYYS PHPSYPCDSL HYVRKPDLKK KRGRPPKLRE SMSDVPFVHG
LGFPLSSGGF YHPSYSVPYS SGPLGLGYYR GYPPASALYP HHQNSHSAPS HHTHHSPSFP
PPPPSSYVHH HHPSHLLLNP SKFHKKKHKL LRQEFLGGGR SPVLYPAMSS ELSFGWHHKH
KHRHKHQERC AEDDGEEGGG ESRGEAEISE SPGSGRGERG AGMAESLQRC RFGRDSTPTT
TSANKQATAT SANSPSSSSS SSAERYKRKE TSLSFLGPSR LAQGSARPRA HQHVESWFRM
GSSEADYAKL SRNPAAVGQS PFTDGQGEDP AGCSDSEEED EEPLTPTDEA DPKSQDPPHH
TNLFATALTP TLLRGGRGRK GGAAESSNFT RLERMLRKEH STLAERREMG GTSSVQTRAD
HSTPEDHLRQ HHHHPPLFHS SSSACLSHCG HNSPSQGCCL DDDASPPHHS HRAQPSKHSL
HHVNKILRAK KLQRQARTGN NMVKKRGPGR PRKHPLPSPP PSPPPLAEVT QTRHRERGGG
AWKGDTVTDA IESVIQGQFR KGQKRKHWER DREEEEEEEG EEVDERALDR EENLGGLGMR
ASAEGGSGWL TQEELHSFRS ALEGKPDGPS SPECPGTVSM EQAPPMPITS QREKRAARPP
KKKFQKAGLY SDVYKTADPR SQLLQMKKEK LEYTPGEHEY GLFPAPIHVG KYLRQKRIDF
QLPYDILWLW KHDQLYEKPD VPLYKKIRSN VYVDVKPVSG YEATTCNCRP SGEAIDRGCL
DECLNRMSFA ECSPGTCPCG EQCDNQHIQR HEWVQCLERF RAEGKGWGIR TKEPLRSGQF
IIEYLGEVVS EHEFRSRMME QYFSHSGQYC LNLDSGMVID SYRMGNEARF INHSCEPNCE
MQKWSVNGVY RIGLFALKDM SSGTELTYDY NFHSFNTEEQ QVCKCGSEGC RGIIGGKSQR
INGMPGKTGG ARRLGRLKEK RKSKHQLKKR VREEDSSDSS KFYPHLLMKP MSNRERNFVL
KHCVFLLRNW EKMREKQELL KREGEREASG GLSIYTRWGG VIRDDGNIKS DVFLTQFSAL
QTSRSVRTRR LAAAEENTEV TRTARLAHIF KEICDMITSY KDSRQEPAFT
//
