ID A0A1S3PXQ1_SALSA Unreviewed; 1154 AA.
AC A0A1S3PXQ1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Histone-lysine N-methyltransferase SETDB1-B-like {ECO:0000313|RefSeq:XP_014032406.1, ECO:0000313|RefSeq:XP_014032407.1};
GN Name=LOC106588190 {ECO:0000313|RefSeq:XP_014032406.1,
GN ECO:0000313|RefSeq:XP_014032407.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014032406.1};
RN [1] {ECO:0000313|RefSeq:XP_014032406.1, ECO:0000313|RefSeq:XP_014032407.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014032406.1,
RC ECO:0000313|RefSeq:XP_014032407.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014032406.1; XM_014176931.1.
DR RefSeq; XP_014032407.1; XM_014176932.1.
DR STRING; 8030.ENSSSAP00000060663; -.
DR GeneID; 106588190; -.
DR KEGG; sasa:106588190; -.
DR OrthoDB; 2877903at2759; -.
DR Proteomes; UP000087266; Chromosome ssa27.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0140938; F:histone H3 methyltransferase activity; IEA:UniProt.
DR GO; GO:0016279; F:protein-lysine N-methyltransferase activity; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd01395; HMT_MBD; 1.
DR CDD; cd10517; SET_SETDB1; 1.
DR Gene3D; 2.30.30.140; -; 3.
DR Gene3D; 2.170.270.10; SET domain; 2.
DR InterPro; IPR016177; DNA-bd_dom_sf.
DR InterPro; IPR040880; DUF5604.
DR InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR InterPro; IPR007728; Pre-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR047232; SETDB1/2-like_MBD.
DR InterPro; IPR041292; Tudor_4.
DR InterPro; IPR041291; TUDOR_5.
DR PANTHER; PTHR46024; HISTONE-LYSINE N-METHYLTRANSFERASE EGGLESS; 1.
DR PANTHER; PTHR46024:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SETDB1; 1.
DR Pfam; PF18300; DUF5604; 1.
DR Pfam; PF01429; MBD; 1.
DR Pfam; PF05033; Pre-SET; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF18358; Tudor_4; 1.
DR Pfam; PF18359; Tudor_5; 1.
DR SMART; SM00391; MBD; 1.
DR SMART; SM00468; PreSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF54171; DNA-binding domain; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50867; PRE_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 788..861
FT /note="Pre-SET"
FT /evidence="ECO:0000259|PROSITE:PS50867"
FT DOMAIN 864..1130
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT REGION 100..152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 164..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..194
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..938
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..961
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 962..980
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 981..1002
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1041
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 128876 MW; 27B823CA72BBE446 CRC64;
MESGDDEMEM TVGELQGWIQ EEVENQDLVK LRRTQLAQMQ NLVQRKEKQA LCTRTLFNTA
CESVVECETV MKALYSKLGM EYRDTDSEDE GVGQQSVIEI DDGEADRNDN TMATDGVAAS
DLAPGEVPAT DSDTENYNDM ADDMESMPSS PAVTTPFVTV TVAPNEASNS NDTPATPLAE
SESEPPSPQE DSGDEYTPSK SKKISTKRPE SSKRGRPRKG ERKRRESVRT KHQLVSYRED
SPPVPTNPSV PTKLQKPKAG DCSASTKQQN SSKGGAASPP KLQEASKSVS TAPLKQQEAR
KETSTPFVVT SVSQAPTHAP NPATQPPPGL TEEEIKTDMK VLARRRTKTW HSGRITEIKP
SENGSRYKVD FSEKGRSMLS GHHIAFDHTA SLERLYVGVR VVAKFKDAEQ SWFYSGILAE
LPNRKNRMRF LVFFDDGTPS YVGLPDLHIV CRPLPEVWED IEDEANREFI KDYIKVYPNP
PMAQYRPGQP INVEFEGIQR RTEVEQIDCS LLCVVFKDDE HKEWVYRGSL RLEHMANMKK
RVEEAKDKPT VTRPNSGGAV STTTTIHQTS TAAANKPHVS PSSTVIPAQV TSNNVSQGQP
AAGKQSASVG RPFVQNRTTD KESSVITAKG SVTFTPHRCC PACLNCIRSK VEAKHRGRNP
LLIPLLCEFR RMKGRHRVNN KTYFHIFYRS PCGLSLSNMT AVQDYLQQTR CDFLFLDMFC
LDPFVSVTTT HQPRPYKINI PDLTLGRENQ PLSCINELNN IRPHSVIYNK QRVAASGVSI
NTSSDFLMGC DCTDGCRDRS ACSCHQLTIQ ATALLPAGPE DVNAGYTHKR LEKRLSTGIY
ECNALCRCDP RVCSNRVVQH GLQLRLQLFM TVGKSWGIRC LDDIAKGTFI CTYTGIIMNK
KSLSTEGNMY MVNLNHIEGA ESKEGYESEA HCSDNESGSE EEPIEEDNSE HDDDCDEGGG
EGEEGNHDKE PLCMKNSYDE EEPSDYEDSY EDKDYDVSED DGGSDDDFRH NVSSMERSYV
TRRHAKILQE DPAKKSGSDA KSSDQQDGTA EGNDKEASNA TRHFFDGEES CYVIDAKLEG
NVGRYLNHSC QPNLFAQNVF VDTHDLRFPW VAFFASKRIR AGTELAWDYK CELGVKRSSR
VLNCRCDPEC REKL
//
