ID A0A1S3PXQ2_SALSA Unreviewed; 417 AA.
AC A0A1S3PXQ2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Growth/differentiation factor 6 {ECO:0000313|RefSeq:XP_014032477.1};
GN Name=gdf6 {ECO:0000313|RefSeq:XP_014032477.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014032477.1};
RN [1] {ECO:0000313|RefSeq:XP_014032477.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014032477.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR RefSeq; XP_014032477.1; XM_014177002.1.
DR AlphaFoldDB; A0A1S3PXQ2; -.
DR STRING; 8030.ENSSSAP00000111804; -.
DR PaxDb; 8030-ENSSSAP00000111804; -.
DR GeneID; 106588223; -.
DR KEGG; sasa:106588223; -.
DR CTD; 30180; -.
DR OMA; HRPKWEV; -.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000087266; Chromosome ssa27.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd13766; TGF_beta_GDF5_6_7; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF285; GROWTH_DIFFERENTIATION FACTOR 6-B; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 293..417
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 265..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..287
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..317
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47728 MW; 3D65E80E1ADCA276 CRC64;
MDFYQITTFY AVLTCVWDLP CFQSFTIFLP SASKSSKVPK VFDGLEAKYF KDMYSSSSSS
SSNERHYKGG LKDSIEPHDY MLSIYKTFST AEKLGLNASF LRSSKAANTI ASFVDIGQDD
LPLSPLRRQQ YLFDVSTLSD RAEVLGAELR IYTKVSGNFR MSEMEPVDIQ LLSCRSQQLL
DSRTLDLQES HRPRWEVLDV WEIFKDRDHL TLGSQFCLEV KAMLDNPERE LDLHHLGFHR
NGRSQQKKAI LVVFTRSKKR QTLFSERREG RTLIGPGEKG KDRGPRSSSK ASRRRRTAIL
KNRHGKRNGN KSKSRCSKKP LRVNFRELGW DDWIIAPLDY EAYHCEGVCD FPLRSHLEPT
NHAIIQTLMN SMNPSNMPPS CCAPSKLSPI SILYIDSGNN VVYKQYEDMV VESCGCR
//
