ID A0A1S3PYJ8_SALSA Unreviewed; 505 AA.
AC A0A1S3PYJ8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Phosphatidylinositol 4-kinase beta isoform X2 {ECO:0000313|RefSeq:XP_014032696.1};
GN Name=LOC106588340 {ECO:0000313|RefSeq:XP_014032696.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014032696.1};
RN [1] {ECO:0000313|RefSeq:XP_014032696.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014032696.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014032696.1; XM_014177221.1.
DR AlphaFoldDB; A0A1S3PYJ8; -.
DR GeneID; 106588340; -.
DR OrthoDB; 147843at2759; -.
DR Proteomes; UP000087266; Chromosome ssa27.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 224..490
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 505 AA; 57169 MW; 6124E39312612244 CRC64;
MTPASPLRLT PQREFIKSLM GIGKRLATLP TKEQKTKQLT SELLVLNHKL PARVWLPTAA
FDHHVVRVPH TQAVVLNSKD KAPYIIYVEV LECESFETSA IPVRIPETRI RSARSADNLL
PECVGITAEQ RAGSFSTVPN YDNDDEAWAV DDIGELQVEL PEGHTSSSDN ISQFSVDSIT
STESKEPIFI AAGDIRRRLS ENLAHTPTTF RKDPEDPSAV ALKEPWQEKV RRIREGSPYG
HLPNWRLLSV IVKCGDDLRQ ELLAFQVLSQ LQSIWEQERV PLWIKPYKIL VMSSDSGMIE
PVLNAVSLHQ VRKQSQLSLL DYFLQEHGSY TTEAFLTAQR NFVESCAGYS LICYLLQVKD
RHNGNILLDS EGHIIHIDFG FILSSSPRNL GFETSAFKLT SEFVDVMGGL DGDMFNYYKV
LMLQGLIAAR KHMEKVVQIV EIMQQGSHLP CFHGSSTIRY LKERFHMSLT EEQLQVLVEQ
MVDGSMRSIT TKLYDGFQYF TNGIM
//
