ID A0A1S3Q1I8_SALSA Unreviewed; 846 AA.
AC A0A1S3Q1I8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Oxysterol-binding protein {ECO:0000256|RuleBase:RU003845};
GN Name=LOC106588858 {ECO:0000313|RefSeq:XP_014033820.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014033820.1};
RN [1] {ECO:0000313|RefSeq:XP_014033820.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014033820.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the OSBP family.
CC {ECO:0000256|RuleBase:RU003844}.
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DR RefSeq; XP_014033820.1; XM_014178345.1.
DR AlphaFoldDB; A0A1S3Q1I8; -.
DR GeneID; 106588858; -.
DR OrthoDB; 960at2759; -.
DR Proteomes; UP000087266; Chromosome ssa27.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR CDD; cd13287; PH_ORP3_ORP6_ORP7; 1.
DR Gene3D; 2.40.160.120; -; 1.
DR Gene3D; 3.30.70.3490; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR037239; OSBP_sf.
DR InterPro; IPR000648; Oxysterol-bd.
DR InterPro; IPR018494; Oxysterol-bd_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041680; PH_8.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10972; OXYSTEROL-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR10972:SF15; OXYSTEROL-BINDING PROTEIN-RELATED PROTEIN 3; 1.
DR Pfam; PF01237; Oxysterol_BP; 1.
DR Pfam; PF15409; PH_8; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF144000; Oxysterol-binding protein-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS01013; OSBP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055,
KW ECO:0000256|RuleBase:RU003845};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003845}.
FT DOMAIN 47..147
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 415..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 467..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 846 AA; 96485 MW; 27A89EB61AF1F704 CRC64;
MLSNRKMTSV SPTHSDVMFG RAGAANHQDS WEIIEGLKGN PGNIQEPEKQ EGFLLKRRKW
PMKGWQKRYF LLEKGILKYS KRGADGKLHG CIDVGLSVMS IKKKTKAIDL DTNNNIYHLK
VKSDKSQEVK SQQLFDDWVS KLRHHRVFRQ NEIAMYPHER LLFHPSSHLS PNPNDSMRQR
HSSLAKQASV VQQAKVSAWL HSSEDMDKCC RDLEECESYL LELNLLLRSM EVLHRTYSAP
AISLMASTYD IPKKEKRGPR KWRSKNYNKD TKKDIMATLQ VPGCVSPPAS PHFHTSHPNL
STAEANIEEA FAFLDSPDSP TDANRLQEDF CRLANNIHST LRSAYSSLSA ERDRVRHTID
LKAPPPAQVM GLKADYGSVS KDLPDGSRPL VHQVSNESRV SIPESMSEFF DAQEYQLTSS
SSENEASDDD DSYISDVSDS VSMDNGYSNE RGSERHESAG SGGSGVQVAR RRTTLPSPQP
SSSSVSLWNI LKNNIGKDLS KIAMPVQLNE PLNTLQRLCE EVEYSELLDT ANNTQDPYQR
MVYVATFAVS AYASSYHRAG SKPFNPVLGE TYECDRPDKG FRFIAEQVSH HPPVSACHCD
SNNFTFWQDV QWKNKFWGKS MEIVRMGTTH VTLPAFGDHY EWNKVTSCIH NILSGQRWIE
HYGEMSIKNT SSDACQCKVT FVKARSWSST VNEIEGMVTD TGGRVIHSFF GKWHEGVYQG
VPPSAICIWR ANPMPVDQDQ YYGFTQFAIE LNELDAALKP HLPPTDTRFR LDQRCLEEGN
IEGAEEQKRR IEELQRERRK VLEENNVTHK PRFFKKSKDD TWLSSNIYWE QRKNPRFSRE
DFPVLW
//
