ID A0A1S3Q2L5_SALSA Unreviewed; 800 AA.
AC A0A1S3Q2L5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Multidrug resistance-associated protein 1-like {ECO:0000313|RefSeq:XP_014034218.1};
GN Name=LOC106589063 {ECO:0000313|RefSeq:XP_014034218.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014034218.1};
RN [1] {ECO:0000313|RefSeq:XP_014034218.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014034218.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014034218.1; XM_014178743.1.
DR AlphaFoldDB; A0A1S3Q2L5; -.
DR KEGG; sasa:106589063; -.
DR Proteomes; UP000087266; Chromosome ssa02.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd18595; ABC_6TM_MRP1_2_3_6_D1_like; 1.
DR CDD; cd03250; ABCC_MRP_domain1; 1.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24223; ATP-BINDING CASSETTE SUB-FAMILY C; 1.
DR PANTHER; PTHR24223:SF339; ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 6; 1.
DR Pfam; PF00664; ABC_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50929; ABC_TM1F; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 25..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 64..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 94..112
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 124..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 163..180
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 416..438
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 444..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 523..550
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 305..587
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 604..800
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 800 AA; 90201 MW; D39392310561EA2B CRC64;
MRNDDWNRTW YTDKPDLTEC FQNTVLVWFP CVYLWLLAPF YALKLYCHDC GCIRISTLCT
AKTVLGFLLA SFGFVEFFYI LLERSHEIQN HMVFLLSPII RSLTVVLAIC IIQLERIRGC
RSSVFLFLFW VLAVVCSLVP LRAKIQLAMY EGITTDIVRY TAFFSYFSLQ LAQLFLCCFA
DQPPEGKTVL VKNPCPVKDA SFLSKMLFWW FTGLVVKGYR TPLEAGDLWN LREEDTSDKI
ISDLEEEWTT ECAKLQQQEK TMAAGVALGT RLPDQAQILR KLQKEQSSGF CLLRTLARNF
GPYFLTGTMC IIFHDFFMFA IPQVLSLLLG FMNEEDAPLW KGYFYATLMF LLSCLQSLFN
HQYMYTCFTV GMRVKTAVMG LVYRKSLVIN SASRRTCTVG EIVNLVSADT QKLMDFVVYF
NAVWLAPIEI ALCLFFLWQH LGPSALAGIA TVILIFPLNG FIAKKRSKLQ EVQMKFMDGR
IKLMNEILNG IKILKFYAWE KAFLEQVLGY REKELKALKK SQILYSISIA SFNSSTFLIA
FAMFGVYVLI DDKNVLDAQK VFVSMALINI LKTPLSQLPF AMSTTMQAIV SLKRLGKYLC
SEELKDDNVA KAPLSTDGEG VLIDNGTFSW TKEGPPCLKR INVCVPQGSL VAVVGHVGSG
KSSLLSAMLG ETEKRSGSVS IKGSVAYVPQ QAWIQNATVQ DNVMFGREKQ KTWYQRVLDA
CALLPDLEIL PAGDSTEIGE KGLNLSGGQK QRVSLARAVY RKADVYLLDD PLSAVDAHVG
QHIFDKVIGP KGVLRDKVKI
//
