ID   A0A1S3Q3T5_SALSA        Unreviewed;       629 AA.
AC   A0A1S3Q3T5;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Transcription factor 7-like 2 isoform X12 {ECO:0000313|RefSeq:XP_014034620.1};
GN   Name=LOC106589326 {ECO:0000313|RefSeq:XP_014034620.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014034620.1};
RN   [1] {ECO:0000313|RefSeq:XP_014034620.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014034620.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC   -!- SIMILARITY: Belongs to the TCF/LEF family.
CC       {ECO:0000256|ARBA:ARBA00006569}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014034620.1; XM_014179145.1.
DR   AlphaFoldDB; A0A1S3Q3T5; -.
DR   GeneID; 106589326; -.
DR   OrthoDB; 5351131at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa28.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd21996; HMG-box_TCF7-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR   InterPro; IPR027397; Catenin-bd_sf.
DR   InterPro; IPR013558; CTNNB1-bd_N.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR024940; TCF/LEF.
DR   PANTHER; PTHR10373; TRANSCRIPTION FACTOR 7 FAMILY MEMBER; 1.
DR   PANTHER; PTHR10373:SF32; TRANSCRIPTION FACTOR 7-LIKE 2; 1.
DR   Pfam; PF08347; CTNNB1_binding; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM01366; c-clamp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT   DOMAIN          340..408
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        340..408
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          1..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          408..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..629
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        16..46
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..91
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..534
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        580..594
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        608..629
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   629 AA;  69240 MW;  FA03A5D6C496AF5F CRC64;
     MPQLNGGGGD DLGANDEMIS FKDEGEQEEK ISENLSAERD LADVKSSLVN ESETNQNSSS
     DSEAERRPPP RSETFRDKTR ESLEEAAKRQ DGGLFKSPPY PGYPFIMIPD LTSPYLPNGS
     LSPTARTYLQ MKWPLLDVNH GSLQSRQALK DARSPSPAHI VSNKVPVVQH PHHVHPLTPL
     ITYSNEHFTP GNPPPHLQGD VDPKTGIPRP PQHPDISPYY PLSPGSVGQL PHPLGWLVPQ
     QGQPVYPITT GGFRHPYPTA LTVNASMQSF LSSRFPHHMV PPHHSLHQTG IPHPAIVTPN
     VKQESSHSDI GLNSSTILYT LHRKHQDSKK EDEKKKQPHI KKPLNAFMLY MKEMRAKVVA
     ECTLKESAAI NQILGRRWHA LTREEQAKYY ELARKERQLH MQLYPGWSAR DNYAGNQQGK
     KKKRKRDKQP GEGNEHREYF PNPCLSLPPI TDLSAPKKCR ARFGLDQQNN WCGPCRRKKK
     CIRYIQGEGS CASPPSSDGS LLDSPPSSPS SVAPSPSSKD SKPQTEQMQP LSLTMKPAHQ
     PLHHPHLLAG HPPPPSLVLL ENSAAAAGKM PGAAHNGAHD HGNVSSSRQP GSSGASLARP
     LAASLCHSHS LHPNSTAPQP LSLVTKSIE
//