ID A0A1S3Q470_SALSA Unreviewed; 1515 AA.
AC A0A1S3Q470;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN Name=plce1 {ECO:0000313|RefSeq:XP_014034737.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014034737.1};
RN [1] {ECO:0000313|RefSeq:XP_014034737.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014034737.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR RefSeq; XP_014034737.1; XM_014179262.1.
DR OrthoDB; 2900494at2759; -.
DR Proteomes; UP000087266; Chromosome ssa28.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd16203; EFh_PI-PLCepsilon; 1.
DR CDD; cd08596; PI-PLCc_epsilon; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR046973; PLC-epsilon1_cat.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR046974; PLC_epsilon1_EF.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR10336:SF6; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE EPSILON-1; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR Pfam; PF00617; RasGEF; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..1515
FT /note="Phosphoinositide phospholipase C"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010370305"
FT DOMAIN 1..176
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT DOMAIN 1105..1195
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 1201..1326
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 435..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..972
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1034..1075
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 456..475
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 930..948
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 949..972
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1515 AA; 169536 MW; F3590E94EC95212F CRC64;
MVSLWVTWLI LTAGTMEKKR EVFSYLVHVA KCCWNMGNYN AVMEFLAGLR SRKVLKMWQF
MDQSDIETMR SLKDAMAQHK SLSEYRKVAL KIPGCKVVPF CGIFLKELSD ALDGAASIIS
LRHSPHDSPE FVTDYGGQEH FLQRVGPDGL HSHEKEATVS NILQIIRSCN RSLETEKGGH
HKGFSTSHRN YFMDRNQFVE GDLSDSEGDL SEQAKEVAFQ GTEETHRAFG HGTELIPWYV
LSLQPDVHQF LLQGSTVIHY DQESHLTARC FLRLEPDNCS LTWANPQSGS TPTDPPGLGQ
PVVSGLAEGL LDLSVVKAVF MGHQGVDMFA VCLQNKLCNT MRAEENGVSL LYGLHTTDNR
LLHFVAPRHT ACILYEGLVE LVNAIRKLKK FPDKRLHWLR RQYVRLYWDE GRYEGPTLAQ
AVKLFGGRCW DMGTEGTEKP SAQKNSSTTK KKKNALVRKY SGDATDDETS QRKTKSCKDT
LCRNGPELYD SVHQEELEDG FPGPFPAPSC KSPGSLTSGS LAFSPILSGS TKAQPGAWSS
KSWHGLGKGY FKGFQDLMSS DSTMSFIEFV ELFKSFSIRS RKDLKELFDT YAVPCSSPGP
ESAPLYTTLR IDDKETGLQP DLDLLTRNGS DLGLFIRTRQ QMSENQKQIS NAIAAASIVT
NGTGVENASL GVLGMAVPQL NDFLVNCQRK HLTYDGILSI IQTFEPCVSI RQMGWMSFEG
FARFLMDKEN FASKNEESQV NAEELQYPMS YYYIESSHNT YLTGHQLKGE SSVELYSQVL
LQGCRSVELD CWDGDDGSPI IYHGYTLTTK IPFKDVVEAI NRTAFVNSDM PVILSIENHC
SLPQQRKMAE IFKVVFGVKL VSNFLFESDF SDDPLLPSPL QLKGKILLKN KKLTAHQAPV
DILKQKTHQL AHIKAQTSNG APGGSSPGNH DDDEEEEDEY EDDCESLSDD NILNDKPERK
SSGDKEDHPI TDEMAKRMKK ADNAVTKYKG KVLDIELEEE LYPPQNKKES RQIAQELSDL
IIYCQAVKFP GLSTLSHSAS GRRKDRKNRK SVFGMDPGRS GSSPKEAVPG KGSVEGTRLS
WEEQTSPVLS PNPSVSAVIH TPKCYHISSV NENTAKRLCR RNSEKLILHT TCQLLRTYPA
ATRIDSANPN PLPFWLHGIQ VVALNYQTDD LPMQLNTALF EANGHCGYVL KPPVLWDRCC
PLYQQLCSLE RDVESISPTL YSLTIVSGQN VCPANSAGSP CVEVDVMGMP VDSFQFRTKP
IHRNTLNPMW SEHFRFPVHF EDACFLRIAV VENNSYQTTA QRILPLRALK PGYRHIQLRT
QHNEPLEVSS LFIYSRRVEE SPTGTALPAA VLFSSEERRA AQQHKVTVHG GPGREPFTVV
SVKEQTTAGQ LLDTLLMSTD GASEYFLCEE KVSLGKERSD RKRCPQQRPV APEEEIIRVI
NSWQPEEGYV GRICLKTKEE MAREDKRKGI SFASELKKVT SFSQSVIAPA TQESSRSTDE
SSRAAYCVPL TEAHE
//
