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Database: UniProt
Entry: A0A1S3Q697_SALSA
LinkDB: A0A1S3Q697_SALSA
Original site: A0A1S3Q697_SALSA 
ID   A0A1S3Q697_SALSA        Unreviewed;       226 AA.
AC   A0A1S3Q697;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   24-JAN-2024, entry version 19.
DE   RecName: Full=Mitochondrial cardiolipin hydrolase {ECO:0000256|ARBA:ARBA00040549};
DE   AltName: Full=Choline phosphatase 6 {ECO:0000256|ARBA:ARBA00042226};
DE   AltName: Full=Mitochondrial phospholipase {ECO:0000256|ARBA:ARBA00043167};
DE   AltName: Full=Phosphatidylcholine-hydrolyzing phospholipase D6 {ECO:0000256|ARBA:ARBA00043135};
DE   AltName: Full=Phospholipase D6 {ECO:0000256|ARBA:ARBA00041680};
GN   Name=LOC106589682 {ECO:0000313|RefSeq:XP_014035427.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014035427.1};
RN   [1] {ECO:0000313|RefSeq:XP_014035427.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014035427.1};
RG   RefSeq;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a cardiolipin + H2O = 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-
CC         glycerol) + a 1,2-diacyl-sn-glycero-3-phosphate + H(+);
CC         Xref=Rhea:RHEA:44884, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:58608, ChEBI:CHEBI:62237, ChEBI:CHEBI:64716;
CC         Evidence={ECO:0000256|ARBA:ARBA00036829};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:44885;
CC         Evidence={ECO:0000256|ARBA:ARBA00036829};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane
CC       {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004572}.
CC   -!- SIMILARITY: Belongs to the phospholipase D family. MitoPLD/Zucchini
CC       subfamily. {ECO:0000256|ARBA:ARBA00038012}.
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DR   RefSeq; XP_014035427.1; XM_014179952.1.
DR   AlphaFoldDB; A0A1S3Q697; -.
DR   GeneID; 106589682; -.
DR   OrthoDB; 1356899at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa02.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR   CDD; cd09171; PLDc_vPLD6_like; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 1.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   PANTHER; PTHR43856; CARDIOLIPIN HYDROLASE; 1.
DR   PANTHER; PTHR43856:SF1; MITOCHONDRIAL CARDIOLIPIN HYDROLASE; 1.
DR   Pfam; PF13091; PLDc_2; 1.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 1.
DR   PROSITE; PS50035; PLD; 1.
PE   3: Inferred from homology;
KW   Differentiation {ECO:0000256|ARBA:ARBA00022871};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801,
KW   ECO:0000313|RefSeq:XP_014035427.1};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00022963};
KW   Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Spermatogenesis {ECO:0000256|ARBA:ARBA00022871};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        6..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          149..176
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   226 AA;  25145 MW;  8433E103C5539509 CRC64;
     MSVVQMVKIV GLGAVALTLS VEWLGWLFCR LWPRKISRGP LKEVFFFPTE VACTERLFTP
     DSPFPCPCPL PHNVNTSFTR LLGHILSASS SLDLCVFAFT NLDLSRAVLA LHARGIPIRI
     LTDMDYTLIT GSQIGAIRRA GICVRCDSGA VHMHHKFAVV DGRRLITGSL NWTLTAIQSN
     KENILVTEEP DLVLPFITEF QRLWDVNDPA RRHLPSIAEK TASLVL
//
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