ID A0A1S3Q6N7_SALSA Unreviewed; 739 AA.
AC A0A1S3Q6N7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Elongin-A {ECO:0000256|ARBA:ARBA00021346};
GN Name=LOC106589809 {ECO:0000313|RefSeq:XP_014035643.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014035643.1};
RN [1] {ECO:0000313|RefSeq:XP_014035643.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014035643.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00649}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014035643.1; XM_014180168.1.
DR AlphaFoldDB; A0A1S3Q6N7; -.
DR STRING; 8030.ENSSSAP00000114090; -.
DR PaxDb; 8030-ENSSSAP00000114090; -.
DR Ensembl; ENSSSAT00000149169; ENSSSAP00000114090; ENSSSAG00000079341.
DR GeneID; 106589809; -.
DR KEGG; sasa:106589809; -.
DR CTD; 768168; -.
DR OMA; CAQGDWH; -.
DR OrthoDB; 4793at2759; -.
DR Proteomes; UP000087266; Chromosome ssa28.
DR Bgee; ENSSSAG00000079341; Expressed in ovary and 2 other cell types or tissues.
DR GO; GO:0070449; C:elongin complex; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR GO; GO:0006368; P:transcription elongation by RNA polymerase II; IEA:InterPro.
DR Gene3D; 6.10.250.3180; -; 1.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR010684; RNA_pol_II_trans_fac_SIII_A.
DR InterPro; IPR003617; TFIIS/CRSP70_N_sub.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR15141; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR PANTHER; PTHR15141:SF76; TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3; 1.
DR Pfam; PF06881; Elongin_A; 1.
DR Pfam; PF08711; Med26; 1.
DR SMART; SM00509; TFS2N; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|RefSeq:XP_014035643.1};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649};
KW Protein biosynthesis {ECO:0000313|RefSeq:XP_014035643.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 1..79
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT DOMAIN 540..584
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 110..389
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 429..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..273
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 703..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 84212 MW; 6E2F5DA56C580FEB CRC64;
MDAHDVSKKV LQLKLQLKET TESKKVLKIL KKLRELDITL DILAETGIGK AVNSLRKHGD
AGEAVRLLVS HWKKLVPKET LSHTEKDDAS QSKLLVTDAE IQNCSKEACS KIEDQSQNTS
KDERLKNDEE NQDGPTSRGV HLKTDEENKA TSEKEHLKTD EKDENFKDEH LEAEYKNQGT
SKDEHLKTED KNQGTAEKAH LQKADEGSSE LKNDHFKSEK ENKRTWKKDN SKDELKKHKG
TRECIMVTEK ESYWSRNSED ENVVLGSTSK SSHKKAKSIS REESKNNSDN GGKCGIRRDS
NRKTLPCTKP SSEESSKSKP DRKGTVIDKS NDQDKVSDSL GCNGERRKPS ERKQVCHEDK
KSKHEGKSKT KEKMAIEDKP NDNDVEVPSM SFESFLSYDI NTPKRKKKSD SDKPPKKFKT
VEKEVKVVKT PSTKSKKQLP AATADFSPPK KAMKGSVMDL LNIPLPTFLP EYDELSNFNY
YDRKMEDKSK VSVSEGPVFT GQRLNRKMQV YSGAKSAFLP TMMSLYQQCI RALQNNIDLL
YEIGGVPFEI LEPVLERCTP DQLFRIEECN PMYVGLTDHL WEKHCQRDFR NAQLEEYESW
REMHMRLSEE RERKLQRLTK TIVSAHSGKP KGRQVKMAFI NSVAKPPRNV RIQQEIHGTA
RHPRIQQENN GTTGVVLPPH PLDRPSVKAQ EKARPCYVEP PRPSTTVSGT SQAQDSRKKT
RVAPMMAKSL KAFKTMGRR
//
