ID A0A1S3QA06_SALSA Unreviewed; 1193 AA.
AC A0A1S3QA06;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Receptor protein-tyrosine kinase {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
DE EC=2.7.10.1 {ECO:0000256|ARBA:ARBA00011902, ECO:0000256|PIRNR:PIRNR000619};
GN Name=LOC106590362 {ECO:0000313|RefSeq:XP_014036776.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014036776.1};
RN [1] {ECO:0000313|RefSeq:XP_014036776.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014036776.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC kinase family. EGF receptor subfamily. {ECO:0000256|PIRNR:PIRNR000619}.
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DR RefSeq; XP_014036776.1; XM_014181301.1.
DR AlphaFoldDB; A0A1S3QA06; -.
DR STRING; 8030.ENSSSAP00000113844; -.
DR PaxDb; 8030-ENSSSAP00000113844; -.
DR Ensembl; ENSSSAT00000180953; ENSSSAP00000160821; ENSSSAG00000078799.
DR GeneID; 106590362; -.
DR KEGG; sasa:106590362; -.
DR OMA; GHEYMNQ; -.
DR OrthoDB; 1614410at2759; -.
DR Proteomes; UP000087266; Chromosome ssa29.
DR Bgee; ENSSSAG00000078799; Expressed in liver and 8 other cell types or tissues.
DR GO; GO:0098590; C:plasma membrane region; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004714; F:transmembrane receptor protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0038127; P:ERBB signaling pathway; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0042127; P:regulation of cell population proliferation; IEA:UniProt.
DR CDD; cd00064; FU; 3.
DR CDD; cd05108; PTKc_EGFR; 1.
DR Gene3D; 6.10.250.2930; -; 1.
DR Gene3D; 3.80.20.20; Receptor L-domain; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR044912; Egfr_JX_dom.
DR InterPro; IPR006211; Furin-like_Cys-rich_dom.
DR InterPro; IPR006212; Furin_repeat.
DR InterPro; IPR032778; GF_recep_IV.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR000494; Rcpt_L-dom.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR049328; TM_ErbB1.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
DR PANTHER; PTHR24416:SF91; EPIDERMAL GROWTH FACTOR RECEPTOR; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00757; Furin-like; 1.
DR Pfam; PF14843; GF_recep_IV; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF01030; Recep_L_domain; 2.
DR Pfam; PF21314; TM_ErbB1; 1.
DR PIRSF; PIRSF000619; TyrPK_EGF-R; 2.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00261; FU; 4.
DR SMART; SM00220; S_TKc; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR000619};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|PIRNR:PIRNR000619};
KW Membrane {ECO:0000256|PIRNR:PIRNR000619, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR000619};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR000619};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR000619};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137,
KW ECO:0000256|PIRNR:PIRNR000619}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..1193
FT /note="Receptor protein-tyrosine kinase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010306525"
FT TRANSMEM 652..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 718..985
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 843
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-1"
FT BINDING 724..732
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2"
FT BINDING 751
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR000619-2,
FT ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 1193 AA; 133403 MW; E0A49CAD4AFB816D CRC64;
MRPETGIVIA AMFCMGCCVT LTAHKKVCQG ISNRLTLLAT VDDHYNNLVK MYSNCTVVLE
NLELTYIQDY HDLSFLKSIQ EVGGYVLIAL NKAASIPLEN LRLIRGHSLF LDKYALTVTS
NYEKNHSSVT LNYTRGLREL KLSGLTEILK GGVKIAHNPL LCNVETIQWW DMVNKAINHS
MHFKLESYGR YCDKCDPGCY NGSCWTSGLE NCQTFTKLTC AEQCSGRCRG PKPSDCCNEH
CAAGCTGPRP TECLACRDFQ DDGTCKDACP PTMLYNPNTH QLASNPNAKY TFGATCVKDC
PHNYVVTDHG ACVRTCSGNT HEVEENGVRR CKKCDGICPK VCDGLGMGLL TKVLSINASN
IDSFKNCTKI NGAVSIMQTS LDGDRYTSTP KMDPAKLEYF KTVKEISGFL LIQAWPEHLD
SLSPFENLEI IRGRTKQFGR VSFAALNLAH LKYLGLRSLR EISDGNVVVK NNPQLCYTNG
DHWKSLFRLG KQSSTVGNNV NISTCAKLNS TCDEMCTDEG CWGPGPTMCF TCLYYTRRGR
CVGACNLLEG VPREYVLNNR CLECDPECLV NGPQSCFGPG PDKCLACAHV KDGPHCVYQC
PHGVLGDRDR HIWKYTDKKR ECQLCHENCT QGCSGPGLSG CSTRGGHVAS VVVARVVGGL
LVFVVLALGV FVLLRRRHIV RKRTLRRLLQ ERELVEPLTP SGEAPNQALL RILKETEFKK
IKVLGSGAFG TVFKGMWIPE GENVKIPVAI KVLREATSPK ANKEILDEAY VMASVEHPHV
CRLLGICLTS TVQLITQIMP YGCLLDYVKE NKDNIGSQCL LNWCVQIAKG MNYLEEHHLV
HRDLAARNVL VKTPHHLKIT DFGLAKLLTA DEKEYHADGG KVPIKWMALE SILHWTYTHQ
SDVWSYGVTV WELMTFGSKP YDGIPAIEIA GVLEKGERLP QPPICTIDVY MIMVKCWMID
AESRPRFREL ISEFSKMARD PSRYLVIQGD DRMYLPSPTE PMFYRSLIST SENMEDAEEY
LHPYKDLSTR QTTQHHNSRN GHPMRENSVI LRYITDPTHG GSLEKDITDP SGSLEKDFPA
LPEYMNQNGN TRLSDVFNPS YEDPTEAAWA SRPSSGYDPD VKFFNFLPCM LEIPEYHNMA
RSTLPRSVCE RMDNPDYQED FLPQATPTSS HFLPAAENLE YLGLSAAVHA PVR
//
