ID A0A1S3QAN9_SALSA Unreviewed; 596 AA.
AC A0A1S3QAN9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Polypeptide N-acetylgalactosaminyltransferase {ECO:0000256|ARBA:ARBA00012644, ECO:0000256|RuleBase:RU361242};
DE EC=2.4.1.- {ECO:0000256|RuleBase:RU361242};
DE AltName: Full=Protein-UDP acetylgalactosaminyltransferase {ECO:0000256|RuleBase:RU361242};
GN Name=LOC106590430 {ECO:0000313|RefSeq:XP_014036939.1,
GN ECO:0000313|RefSeq:XP_014036940.1, ECO:0000313|RefSeq:XP_014036941.1,
GN ECO:0000313|RefSeq:XP_014036942.1, ECO:0000313|RefSeq:XP_014036943.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014036942.1};
RN [1] {ECO:0000313|RefSeq:XP_014036939.1, ECO:0000313|RefSeq:XP_014036940.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014036939.1,
RC ECO:0000313|RefSeq:XP_014036940.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936,
CC ECO:0000256|RuleBase:RU361242};
CC -!- PATHWAY: Protein modification; protein glycosylation.
CC {ECO:0000256|ARBA:ARBA00004922, ECO:0000256|RuleBase:RU361242}.
CC -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC {ECO:0000256|RuleBase:RU361242}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU361242}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. GalNAc-T
CC subfamily. {ECO:0000256|ARBA:ARBA00005680,
CC ECO:0000256|RuleBase:RU361242}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014036939.1; XM_014181464.1.
DR RefSeq; XP_014036940.1; XM_014181465.1.
DR RefSeq; XP_014036941.1; XM_014181466.1.
DR RefSeq; XP_014036942.1; XM_014181467.1.
DR RefSeq; XP_014036943.1; XM_014181468.1.
DR STRING; 8030.ENSSSAP00000116081; -.
DR PaxDb; 8030-ENSSSAP00000116081; -.
DR GeneID; 106590430; -.
DR KEGG; sasa:106590430; -.
DR OrthoDB; 202750at2759; -.
DR UniPathway; UPA00378; -.
DR Proteomes; UP000087266; Chromosome ssa29.
DR Bgee; ENSSSAG00000080029; Expressed in liver and 14 other cell types or tissues.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004653; F:polypeptide N-acetylgalactosaminyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006486; P:protein glycosylation; IEA:UniProtKB-UniPathway.
DR CDD; cd02510; pp-GalNAc-T; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR045885; GalNAc-T.
DR InterPro; IPR001173; Glyco_trans_2-like.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR11675; N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR PANTHER; PTHR11675:SF63; POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE; 1.
DR Pfam; PF00535; Glycos_transf_2; 1.
DR Pfam; PF00652; Ricin_B_lectin; 1.
DR SMART; SM00458; RICIN; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|RuleBase:RU361242};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU361242};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|RuleBase:RU361242};
KW Lectin {ECO:0000256|ARBA:ARBA00022734, ECO:0000256|RuleBase:RU361242};
KW Manganese {ECO:0000256|ARBA:ARBA00023211, ECO:0000256|RuleBase:RU361242};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU361242};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361242};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361242}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361242"
FT DOMAIN 464..595
FT /note="Ricin B lectin"
FT /evidence="ECO:0000259|SMART:SM00458"
SQ SEQUENCE 596 AA; 67243 MW; 47A4BB1DBBC283C1 CRC64;
MGSVTLRYFC YGCLFTSVTW SVLLFLYFSL SQDSGRPSFR NVPIQGPQAK RFQSRFTRSP
GGGHEQGIKA VPAARGNKKA DLSPEMGMIF NEQDQEVRDT GYHKHAFNVL ISNRLGFHRD
LPDTRDDRCR DGIYPLSLPT ASVVICFFNE AFSALLRTVH SVLDRTPAYL LHEIILVDDS
SELADLKEDL DSYVQLNLQG KVKVVRNEKR EGLIRGRMIG ASHATGEVLV FLDSHCEVNE
AWLRPLLAPI QRDRKTVVCP IIDIISADTL AYSPSPIVRG GFNWGLHFKW DPVPASELTG
PDGALGAIRS PTMAGGLFAM DRKYFNELGQ YDSGMDIWGG ENLEISFRIW MCGGQLLIVP
CSRVGHIFRK RRPYGSPGGQ DTMAHNSLRL AHVWMDEYKE QYFNLRPELR ERAYGDISER
QAVRQRLQCH SFKWYLDTIY PEMQVASTHN KPQQPVFVNK GLRRPKVLER GRLRNLQADK
CLVAQGRPSQ KGGAVVLRAC DTHNLEQEWA YDEEHELILT DLLCLDMSEI RSSDPPRLMK
CHGSGGSQQW TLGKSNRLYQ VSVGQCLAVV DTISPKGYVT MAICDGSQSQ QWQLEG
//
