ID A0A1S3QAR9_SALSA Unreviewed; 289 AA.
AC A0A1S3QAR9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Tumor necrosis factor ligand superfamily member 10-like isoform X2 {ECO:0000313|RefSeq:XP_014037083.1};
GN Name=LOC106590519 {ECO:0000313|RefSeq:XP_014037083.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014037083.1};
RN [1] {ECO:0000313|RefSeq:XP_014037083.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014037083.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004606}; Single-
CC pass type II membrane protein {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR RefSeq; XP_014037083.1; XM_014181608.1.
DR AlphaFoldDB; A0A1S3QAR9; -.
DR STRING; 8030.ENSSSAP00000110695; -.
DR PaxDb; 8030-ENSSSAP00000110695; -.
DR GeneID; 106590519; -.
DR OMA; EPIMLMK; -.
DR OrthoDB; 5348190at2759; -.
DR Proteomes; UP000087266; Chromosome ssa29.
DR Bgee; ENSSSAG00000078161; Expressed in zone of skin and 15 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR017355; TNF_ligand_10/11.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11471:SF27; TUMOR NECROSIS FACTOR LIGAND SUPERFAMILY MEMBER 10; 1.
DR Pfam; PF00229; TNF; 1.
DR PIRSF; PIRSF038013; TNF10_TNF11; 1.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR038013-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Zinc {ECO:0000256|PIRSR:PIRSR038013-50}.
FT DOMAIN 124..288
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
FT REGION 119..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 238
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /ligand_note="ligand shared between all trimeric partners"
FT /evidence="ECO:0000256|PIRSR:PIRSR038013-50"
SQ SEQUENCE 289 AA; 31854 MW; 27BA03AA3241A8D5 CRC64;
MAGGSSGVSF LGVLLLAAIL VQTVAVTVTV LYFTNVLNTM KEMFARSSVS CLTRADLRGG
YISSSTEGRG NPCWQVTQQL HALIEKSLSQ RYQREISSAV RDEVSRVLPS LVMEDRAPSR
PNVAAHVTGS LTPKAEREGG GSPGRRVQGQ KISWWEGHKG LAFLQEVRLV DGELVVPRPG
LYYIYAQTYF RHTHPEGEGG EEEEEREQRG RPMLQYVYKK VSSYPVPILL MKTSRTSCWS
RDSQFSLHSA HQGGLFPLAA GDHLLVTVSN ASAIDMDERS SFFGAFLVS
//
