ID A0A1S3QDK2_SALSA Unreviewed; 314 AA.
AC A0A1S3QDK2;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Zinc transporter ZIP9 {ECO:0000256|RuleBase:RU369011};
DE Short=ZIP-9 {ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Solute carrier family 39 member 9 {ECO:0000256|RuleBase:RU369011};
DE AltName: Full=Zrt- and Irt-like protein 9 {ECO:0000256|RuleBase:RU369011};
GN Name=LOC106591369 {ECO:0000313|RefSeq:XP_014038068.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014038068.1};
RN [1] {ECO:0000313|RefSeq:XP_014038068.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Transports zinc ions across cell and organelle membranes into
CC the cytoplasm and regulates intracellular zinc homeostasis.
CC Participates in the zinc ions efflux out of the secretory compartments.
CC Also functions as membrane androgen receptor that mediates, through a G
CC protein, the non-classical androgen signaling pathway, characterized by
CC the activation of MAPK3/MAPK1 (Erk1/2) and transcription factors CREB1
CC or ATF1. Moreover, has dual functions as membrane-bound androgen
CC receptor and as an androgen-dependent zinc transporter both of which
CC are mediated through an inhibitory G protein (Gi) that mediates both
CC MAP kinase and zinc signaling leading to the androgen-dependent
CC apoptotic process. {ECO:0000256|RuleBase:RU369011}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU369011};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU369011}. Cytoplasm,
CC perinuclear region {ECO:0000256|ARBA:ARBA00004556,
CC ECO:0000256|RuleBase:RU369011}. Golgi apparatus, trans-Golgi network
CC membrane {ECO:0000256|ARBA:ARBA00004198,
CC ECO:0000256|RuleBase:RU369011}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173, ECO:0000256|RuleBase:RU369011}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU369011}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|RuleBase:RU369011}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014038068.1; XM_014182593.1.
DR AlphaFoldDB; A0A1S3QDK2; -.
DR KEGG; sasa:106591369; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR InterPro; IPR003689; ZIP.
DR InterPro; IPR045891; ZIP9.
DR PANTHER; PTHR16133; SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED; 1.
DR PANTHER; PTHR16133:SF5; ZINC TRANSPORTER ZIP9; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|RuleBase:RU369011};
KW Ion transport {ECO:0000256|RuleBase:RU369011};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369011};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369011};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369011}; Transport {ECO:0000256|RuleBase:RU369011};
KW Zinc {ECO:0000256|RuleBase:RU369011};
KW Zinc transport {ECO:0000256|RuleBase:RU369011}.
FT TRANSMEM 6..30
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 37..57
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 108..126
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 181..203
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 215..235
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 247..268
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
FT TRANSMEM 289..308
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369011"
SQ SEQUENCE 314 AA; 32294 MW; B8774499330E7AFA CRC64;
MSIDDFTSIS LLSLAMLVGC YVAGTIPLAV NFSEEKLKLV TVLGAGLLCG TALAVIIPEG
VHALYEEVLE GAHHAPGQVK GVEVSEPKEG VDAALGVSGE HSHSHEHLHA YIGVSLVLGF
VFMLLVDQIG SAHVHSSADD PESARVASSK ITTTLGLVVH AAADGVALGA AASTSQTSVQ
LIVFVAIMLH KAPAAFGLVS FLMHAGLERN RIRKHLLAFA LAAPVLAMVT FVGLSQSSKE
ALSNVNATGV AMLFSAGTFL YVATVHVLPE VGGTGHSHSP TPGKEAAKGL SKMEVGALVL
GCLIPLVLSV GHHH
//
