ID A0A1S3QIB9_SALSA Unreviewed; 633 AA.
AC A0A1S3QIB9;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Neuronal acetylcholine receptor subunit beta-2-like {ECO:0000313|RefSeq:XP_014039532.1};
GN Name=LOC106592732 {ECO:0000313|RefSeq:XP_014039532.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014039532.1};
RN [1] {ECO:0000313|RefSeq:XP_014039532.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014039532.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_014039532.1; XM_014184057.1.
DR AlphaFoldDB; A0A1S3QIB9; -.
DR STRING; 8030.ENSSSAP00000076276; -.
DR PaxDb; 8030-ENSSSAP00000076276; -.
DR KEGG; sasa:106592732; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd19064; LGIC_TM_nAChR; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR Gene3D; 1.20.58.390; Neurotransmitter-gated ion-channel transmembrane domain; 2.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR006029; Neurotrans-gated_channel_TM.
DR PANTHER; PTHR18945:SF901; NEURONAL ACETYLCHOLINE RECEPTOR SUBUNIT BETA-2; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR Pfam; PF02932; Neur_chan_memb; 1.
DR SUPFAM; SSF90112; Neurotransmitter-gated ion-channel transmembrane pore; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170,
KW ECO:0000313|RefSeq:XP_014039532.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 73..94
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..159
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..72
FT /note="Neurotransmitter-gated ion-channel ligand-binding"
FT /evidence="ECO:0000259|Pfam:PF02931"
FT DOMAIN 79..364
FT /note="Neurotransmitter-gated ion-channel transmembrane"
FT /evidence="ECO:0000259|Pfam:PF02932"
FT REGION 195..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..294
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 195..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..401
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..435
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..622
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|RefSeq:XP_014039532.1"
SQ SEQUENCE 633 AA; 69956 MW; 156A0B641FE376E0 CRC64;
PFDQQNCTMR FRSWTYDRTE IDLILRSDVA SMDDFTPSGE WDIIALPGRR NENPADPTYV
DITYDFIIRR KPLFYTINLI IPCVLITSLA ILVFYLPSDC GEKMTLCISV LLALTVFLLL
ISKIVPPTSL DVPLVGKYLM FTMVLVTFSI VTSVCVLNVH HRSPTTHTMP PWVKLVFLNK
LPALLFMRQP RNSCERQKLR QRRRGQEQRE GGRDGGSAGG LMVGLGLGGG GGGTDNNEPC
TCYVNRASVK QFVGELGGGA GGGGGGGSME GLNGLREGRE GGQGNRPRGK QVGGGPALTQ
AVLGQACPGL EEAVDGVRFI ANHMKTEDDD QSVSEDWKYV AMVIDRLFLW IFIIVCVSGT
VGMFLQPLFQ NYTAKTITNT KWLTNQGAQQ HRWTPPRPNQ HSRTGAGGRD LPSRGRHPQE
NPRTSPEEPQ DISRRTPGHP QENPRTSPGE AQDIPRRTPG HLQERPRTSP GEPQDISRRT
PGHPQENPRT SPEEPQDIPR RTLGHPQENP RTSPEEPQDI PRRTLGHPQE NPRTSPGEPQ
DILRRTPGHP QENPRTSPGE PRTSPGEPQD ILRRTPGHPQ ERPRTPPGEG QDIPSRAPGH
PQENPRTSPA EAQENPNTSP EEPQDIPRRG PGV
//
