ID A0A1S3QJM5_SALSA Unreviewed; 564 AA.
AC A0A1S3QJM5;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Equilibrative nucleoside transporter 4 {ECO:0000313|RefSeq:XP_014039982.1};
GN Name=slc29a4 {ECO:0000313|RefSeq:XP_014039982.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014039982.1};
RN [1] {ECO:0000313|RefSeq:XP_014039982.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.
CC {ECO:0000256|ARBA:ARBA00007965}.
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DR RefSeq; XP_014039982.1; XM_014184507.1.
DR AlphaFoldDB; A0A1S3QJM5; -.
DR STRING; 8030.ENSSSAP00000055029; -.
DR PaxDb; 8030-ENSSSAP00000055029; -.
DR KEGG; sasa:106593173; -.
DR OrthoDB; 2939652at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005337; F:nucleoside transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002259; Eqnu_transpt.
DR InterPro; IPR036259; MFS_trans_sf.
DR PANTHER; PTHR10332; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER; 1.
DR PANTHER; PTHR10332:SF89; EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4; 1.
DR Pfam; PF01733; Nucleoside_tran; 1.
DR PRINTS; PR01130; DERENTRNSPRT.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 109..128
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 148..165
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..221
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 241..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..413
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 425..447
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 454..478
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 490..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 528..545
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..51
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 62663 MW; CA0B98574A2A745F CRC64;
MSAAGVERRR PTSAQTPEER EGGEGWCQGG REEREGWGDA GREEREGWSQ PGRAGWREGR
ESGVVQSYSF DSYQLEEEEG TKSVPERGVL ALAEPAFEEP VPDDRYHGIY FAMLLAGVGF
LLPYNSFITD VDYLHHKFQG SSIVFDMSLV YIVVALVAVI VNNILVERIS LHTRITVGYL
FALGPLVFVS VFDVWLESFT TRQAYVVNLF SVGVVAFGCT VQQSSFYGYM GMLPKRYTQG
VMTGESTAGV IISLSRIFTK LLISNERINT LIFFLVSITI EMLCFLLHLI VRRSRFVRYY
TGPTHRGHGQ GIGHDIGSEV SGTGYRVHHD VTTEEVRFGN GVAATTSPSD DVTDEFTGGT
YVRFGIPKDK IRRSWPGLRD MFLHRYIVAR VIWAYMLSIA VTYSITLCLF PGLESEIRNP
TLGEWLPILI MATFNMADFV GKILAALPYE WTGVYLLLFS CLRVVFIPLL VMCVYPSSTP
TLSHPVWPCL FSLLMGVTNG YFGSVPMIQA AGKVPPEQRE LAGNTMTVSY MTGLMLGSAV
AYAAYSFTAP GSNTHTHTNI TTGY
//
