ID   A0A1S3QLZ2_SALSA        Unreviewed;       469 AA.
AC   A0A1S3QLZ2;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Rho guanine nucleotide exchange factor 3-like {ECO:0000313|RefSeq:XP_014041001.1};
GN   Name=LOC106594155 {ECO:0000313|RefSeq:XP_014041001.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014041001.1};
RN   [1] {ECO:0000313|RefSeq:XP_014041001.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR   RefSeq; XP_014041001.1; XM_014185526.1.
DR   AlphaFoldDB; A0A1S3QLZ2; -.
DR   STRING; 8030.ENSSSAP00000025785; -.
DR   PaxDb; 8030-ENSSSAP00000025785; -.
DR   KEGG; sasa:106594155; -.
DR   Proteomes; UP000087266; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR46006:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3; 1.
DR   PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          96..278
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          302..425
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   469 AA;  53102 MW;  CC93C281E36F1410 CRC64;
     MMSDLMKDSE EPSNKRVKPV GKGGGVTGII TPVKTPALKR LGKSITRSIS FRTEARPLPP
     APIRSRQKAS SFPRRRSSQC WSDTVDSHDL TAKEIKRQEV IYELTEGERQ LIEDLRLVKK
     VYYEPMLTLD IMTESELGQI FGTLDSLIPL HEDLLARLER LRGSEKTVGA VGITLFNWFP
     CLEAYVTYCC NQVEAKALLD MKKQQKRVEQ FLRLCQESSF SRKLDLWNFL DLPRSRLVKY
     PLLLREILKS TPPDHPDEDT LPDALELVQS IVSEVDRKTG EAECQFYRRG LAYLEDGQRL
     PEIQLSRFLY CHGELKNSKG QKLHVFLFEL CLVLTRSVED KEGCVVFQVY RQPLPTATLH
     LEDLPDGEGG GGGAFRGAFT SGNDKVRNCL RVSSRGRSKA QSHSLQANDS FNKQQWISCL
     RQAMVQSRDR DAQVSQSPLS SRLSPDFALY HIAELSLSSD AEMADQSSQ
//