ID A0A1S3QMK4_SALSA Unreviewed; 1154 AA.
AC A0A1S3QMK4;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Replication factor C subunit 1 {ECO:0000256|ARBA:ARBA00020401, ECO:0000256|PIRNR:PIRNR036578};
GN Name=rfc1 {ECO:0000313|RefSeq:XP_014041288.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014041288.1};
RN [1] {ECO:0000313|RefSeq:XP_014041288.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PIRNR:PIRNR036578}.
CC -!- SIMILARITY: Belongs to the activator 1 large subunit family.
CC {ECO:0000256|ARBA:ARBA00006116, ECO:0000256|PIRNR:PIRNR036578}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014041288.1; XM_014185813.1.
DR AlphaFoldDB; A0A1S3QMK4; -.
DR KEGG; sasa:106594440; -.
DR OrthoDB; 6297at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005663; C:DNA replication factor C complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003689; F:DNA clamp loader activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd17752; BRCT_RFC1; 1.
DR CDD; cd18140; HLD_clamp_RFC; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR013725; DNA_replication_fac_RFC1_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR012178; RFC1.
DR InterPro; IPR047854; RFC_lid.
DR PANTHER; PTHR23389; CHROMOSOME TRANSMISSION FIDELITY FACTOR 18; 1.
DR PANTHER; PTHR23389:SF36; REPLICATION FACTOR C SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF08519; RFC1; 1.
DR PIRSF; PIRSF036578; RFC1; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
DR PROSITE; PS50172; BRCT; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PIRNR:PIRNR036578};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR036578};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|PIRNR:PIRNR036578}; Nucleus {ECO:0000256|PIRNR:PIRNR036578};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 410..488
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 1..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 238..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1083..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..29
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..44
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 45..59
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..260
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 261..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 310..324
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 347..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 565..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1117
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1154 AA; 126160 MW; F213D7E21C20F11F CRC64;
MDIRRFFVSS KPAAQKPSQD GNLNTESPKK KSVSTDEEVK KKQTATKVVK KKKKDSDKKT
KKRAVIESDS EEEVVEHKQK VRKQHPPLPP AKKDPVQYVS ETDSDSDNFL SLKKSAKPQD
NGVTKPGKAR TGTKEIYRSP SKPTPAPAKG KGVIKKSPPA PVTPKSAPQH TKRTPTSVLD
YFGSGSVQRS GKKLVASTKR KADHDESLTD EVIAQQLQMD EDMELERLVH EDEEFARTLA
MLDQEPHAKK ARKDSGKDLG SDTSANKSIA NSSHSSTTSQ SQSNGRDHNQ DVIGPSPKKV
PPLVKTSSKL AVMKRREVEE EGGGKTNLTI KMPVSPKKEF LTTSSTDRKS KPKTGSVTMV
TTRTTLKTSP KKESTSPEDS EKKRGNSSAF RSFLNRDGPR ALGSKPIPTG AENCLEGCVF
VISGVLESME REDAKSLIER YGGKVTGNVS KRTTYLVMGR DGGAAKTDKA EGFGTKILDE
DGLLELIRCS PGKKSKYLIA AEAENKGFKS RTPDTEALSR TPKQSSKPSP SKPGSASGRG
VRVGDSVTPP ARGTGSGVKR GLDLGGKSQS SSSSATPSLP SFAGEDFSLL WVDKYRPQNL
KAVIGQQGDQ SQANKLLRWL KNWHTHHAVG GAKPAGRGFG KFSSTKDNGS SFKAALLSGP
PGVGKTTTAA LVCQELGYSY VEMNASCTRS KNSLNLIAES LNNSSINNYY TGSSQTVSSK
HVLIMDEIDG MAGNEDRGGI QEMIGLIKQS RIPIICMCND RNHQKIRSLA NYCFDLRFQR
PRLEQIKGAM MSIAFKEGLK VPPPALNEMI LASNQDIRQV LHNLSMWSAK DKVMTYDRVK
EDANNARKDM KLGPFDVCRK VFSKGEESGH MTLIDKSDLF FHDYALAPLF IQENYIHVRP
AAAGGDLKSH LVLLSKTADC ICDGDLVDRQ IRSKQAWSLL PTQAIYSSVL PGELMRGYMN
SFPSFPSWLG KFSSCNKHSR IIQELASHMS LKTLSSRQAV SLDYLPYLRM SLLCPLQRRG
AEGAGQAVQL LDDYHLVRED VDSLMEISLW GGQPDPYAQL DPKVKSAFTR AYNRETHLTP
YSLQPIKKGR RGGGVEAELG GEEQAEQPEE EEEEEGVAAD AMIKKKAKPS KEPKKEKTTA
GDSGKGKGKG KGRK
//
