ID A0A1S3QNU6_SALSA Unreviewed; 528 AA.
AC A0A1S3QNU6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Serine/threonine-protein phosphatase with EF-hands 2-like {ECO:0000313|RefSeq:XP_014041636.1};
GN Name=LOC106594775 {ECO:0000313|RefSeq:XP_014041636.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014041636.1};
RN [1] {ECO:0000313|RefSeq:XP_014041636.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014041636.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SIMILARITY: Belongs to the PPP phosphatase family.
CC {ECO:0000256|ARBA:ARBA00008294}.
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DR RefSeq; XP_014041636.1; XM_014186161.1.
DR AlphaFoldDB; A0A1S3QNU6; -.
DR KEGG; sasa:106594775; -.
DR OrthoDB; 3076469at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR CDD; cd00051; EFh; 1.
DR Gene3D; 3.60.21.10; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR004843; Calcineurin-like_PHP_ApaH.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR029052; Metallo-depent_PP-like.
DR InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR PANTHER; PTHR45668; SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED; 1.
DR PANTHER; PTHR45668:SF1; SERINE_THREONINE-PROTEIN PHOSPHATASE WITH EF-HANDS 1; 1.
DR Pfam; PF13202; EF-hand_5; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00149; Metallophos; 1.
DR PRINTS; PR00114; STPHPHTASE.
DR SMART; SM00054; EFh; 3.
DR SMART; SM00156; PP2Ac; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF56300; Metallo-dependent phosphatases; 1.
DR PROSITE; PS00018; EF_HAND_1; 3.
DR PROSITE; PS50222; EF_HAND_2; 3.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT DOMAIN 356..391
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 439..474
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 479..514
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 168..182
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 59895 MW; F0F291FD07FA4A99 CRC64;
MEPESPRCRS KGQAESPRCR SRGQDHGQPE SPRCRGQPES PRCRGQPESP RCRGQPESPR
CRGQPESPRC RGQPESPRCR GQPESPRCRG QPESPRCRGQ PESPRCRGHP ESPRCRSRGQ
AESPRCRSRG QPESPRCRSR GQAESPRCRS MGQDHGNIPK KRRHLTRQGS SSSSSSLCSP
RGSSRLTLRR CLSPSMLSST DNLQVPFLDS FTALPVRQPP REELEWKQVV DLLWSDPKSQ
PGCSPNTFRG GGSYFGPDVT RRLLERHGMT LLIRSHECKQ EGYELCHDGQ VITIFSASNY
YEEGSNRGAY LKLGRELVPR FFQYQVSRNT RKLTLTQRVN VAEGSAVRAV QEKLFAHRSE
LMAAFQQYDT SNSGCISICE WALVVESVLR LDLPWRTLRP RLAQLAPDGR IDYQSCFEDM
GPGQPIAQVT PNLAETLYRY RTDLEIIFNI MDKDHSGQIS IEEFRQTWRL FSAHLGVEVD
DRAIDELAKS IDFNKDGSID FNEFLEAFRV VHKLDVKDQT AGLRETLL
//
