ID A0A1S3QPG7_SALSA Unreviewed; 318 AA.
AC A0A1S3QPG7;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Histone-arginine methyltransferase CARM1 {ECO:0000256|ARBA:ARBA00021804};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE AltName: Full=Coactivator-associated arginine methyltransferase 1 {ECO:0000256|ARBA:ARBA00033236};
DE AltName: Full=Protein arginine N-methyltransferase 4 {ECO:0000256|ARBA:ARBA00030670};
GN Name=LOC106595104 {ECO:0000313|RefSeq:XP_014041953.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014041953.1};
RN [1] {ECO:0000313|RefSeq:XP_014041953.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014041953.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_014041953.1; XM_014186478.1.
DR AlphaFoldDB; A0A1S3QPG7; -.
DR STRING; 8030.ENSSSAP00000021156; -.
DR PaxDb; 8030-ENSSSAP00000021156; -.
DR KEGG; sasa:106595104; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0035242; F:protein-arginine omega-N asymmetric methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd13330; PH_CARM1; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR020989; Histone-Arg_MeTrfase_N.
DR InterPro; IPR041698; Methyltransf_25.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF51; HISTONE-ARGININE METHYLTRANSFERASE CARM1; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF11531; CARM1; 1.
DR Pfam; PF13649; Methyltransf_25; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015}; Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..318
FT /note="Histone-arginine methyltransferase CARM1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010164675"
FT DOMAIN 33..144
FT /note="Histone-arginine methyltransferase CARM1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11531"
FT DOMAIN 193..288
FT /note="Methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF13649"
SQ SEQUENCE 318 AA; 35509 MW; F2E77B7EED823DA0 CRC64;
MQLLLWVAVA SSTVVCLIGK SDPTKQSQVA KMAVSVFPCV RLRSIGDANG EIQRHSEQQP
LRLEVKSTPD TALLNLSNSD ETSVFKCSLS RETECSRVGK QSFIITLGCN SVLLQFSTPA
EFTSFYNILK SCRGHNAEHS VFSDRTEESS AVQYFQFYGY LSQQQNMMQD YVRTGTYQRA
ILQNHVDFKD KVVLDVGCGS GILSFFAAQA GARKVYAVEA STMAQHAEVL VNSNGMGDRV
VVIAGKVEEI SLPEQVDIII SEPMGYMLFN ERMLESYLHA KKFLKPNGNM FPTLGDVHLA
PFTDEQLYME QFTKANFW
//