ID A0A1S3QVV1_SALSA Unreviewed; 1369 AA.
AC A0A1S3QVV1;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Complement C3-like {ECO:0000313|RefSeq:XP_014044031.1};
GN Name=LOC106597357 {ECO:0000313|RefSeq:XP_014044031.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014044031.1};
RN [1] {ECO:0000313|RefSeq:XP_014044031.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014044031.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
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DR RefSeq; XP_014044031.1; XM_014188556.1.
DR STRING; 8030.ENSSSAP00000069397; -.
DR PaxDb; 8030-ENSSSAP00000069397; -.
DR KEGG; sasa:106597357; -.
DR OrthoDB; 4033541at2759; -.
DR Proteomes; UP000087266; Unplaced.
DR GO; GO:0005615; C:extracellular space; IEA:InterPro.
DR GO; GO:0004866; F:endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd00017; ANATO; 1.
DR CDD; cd02896; complement_C3_C4_C5; 1.
DR Gene3D; 1.50.10.20; -; 1.
DR Gene3D; 2.20.130.20; -; 1.
DR Gene3D; 2.20.210.20; -; 1.
DR Gene3D; 2.60.120.1540; -; 1.
DR Gene3D; 2.60.40.1930; -; 3.
DR Gene3D; 2.60.40.1940; -; 1.
DR Gene3D; 6.20.50.160; -; 1.
DR Gene3D; 1.20.91.20; Anaphylotoxins (complement system); 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR011625; A2M_N_BRD.
DR InterPro; IPR047565; Alpha-macroglob_thiol-ester_cl.
DR InterPro; IPR011626; Alpha-macroglobulin_TED.
DR InterPro; IPR000020; Anaphylatoxin/fibulin.
DR InterPro; IPR018081; Anaphylatoxin_comp_syst.
DR InterPro; IPR041425; C3/4/5_MG1.
DR InterPro; IPR048848; C3_CUB2.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR001599; Macroglobln_a2.
DR InterPro; IPR019742; MacrogloblnA2_CS.
DR InterPro; IPR002890; MG2.
DR InterPro; IPR041555; MG3.
DR InterPro; IPR040839; MG4.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR PANTHER; PTHR11412:SF81; COMPLEMENT C3; 1.
DR PANTHER; PTHR11412; MACROGLOBULIN / COMPLEMENT; 1.
DR Pfam; PF00207; A2M; 1.
DR Pfam; PF07703; A2M_BRD; 1.
DR Pfam; PF01821; ANATO; 1.
DR Pfam; PF21308; C3_CUB2; 1.
DR Pfam; PF17790; MG1; 1.
DR Pfam; PF01835; MG2; 1.
DR Pfam; PF17791; MG3; 1.
DR Pfam; PF17789; MG4; 1.
DR Pfam; PF07678; TED_complement; 1.
DR SMART; SM01360; A2M; 1.
DR SMART; SM01359; A2M_N_2; 1.
DR SMART; SM00104; ANATO; 1.
DR SMART; SM01419; Thiol-ester_cl; 1.
DR SUPFAM; SSF47686; Anaphylotoxins (complement system); 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 1.
DR PROSITE; PS00477; ALPHA_2_MACROGLOBULIN; 1.
DR PROSITE; PS01177; ANAPHYLATOXIN_1; 1.
DR PROSITE; PS01178; ANAPHYLATOXIN_2; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1369
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010356782"
FT DOMAIN 693..728
FT /note="Anaphylatoxin-like"
FT /evidence="ECO:0000259|PROSITE:PS01178"
FT REGION 952..973
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1369
FT /evidence="ECO:0000313|RefSeq:XP_014044031.1"
SQ SEQUENCE 1369 AA; 150998 MW; AC021F2D9FABEA70 CRC64;
MWVGNLLCLA ALAVALSLPT LSDGAALLVL SAPNLLRVGS NENIFVESQD HAGGPLNVKI
MVKNHPTQSK ELASKSVVLD QANNFQAMTQ LVIPEGDHFV DDPKQKQYVV LQAQFPDRLL
EKVVLVSFQS GYIFIQTDKT IYTPASTVYY RVFSMSPGLE PLTREIFVDK EVAKNKEIAV
SVEIMTPENI TIFREIVNPD KGVKSGQFNL PEIVSFGTWH VVTRFQSTPQ KTFSSDFEVK
EYVLPSFEVS LTPAKAFFYV DDKDLTVDIT ARYLYGKEVT GTGYVVFGVI TTENEKKSFP
ASLQRVEIKE GKGVACLKKE HITQTFPNIN DLVKQSIFIS VSVLTEGGGE MVEAEKRGIQ
IVTSPYTILF KRTPKYFKPG MPFDVSVYIT NPDNSPASGV EIDVTPDNAK GVTRDNGFAK
ISLNTVASAK ELAITVKTKD PAIPDNRQAE ATMKALPYRT STGNFLHVGV DSNELKIGDP
IKINLNLGPT PIQIHDLTYM FLSRGQLVKV GRFKRQGNAL VTLSVPVSKE MLPSFRIVAY
YHVGADDLVA DSVWVDIKVS CMGSLKVTST RPKASYEPRK AFSLTVTGDP GAKVGLVAVD
KGVYILNSKH RLTQAKIWDT IEKHDTGCTA GGGADNMGVF YDAGLVFETN TAKGTGIRTD
PSCPVSSRRR RAVTISDVIT SMASKYNGLA KECCVDGMRD NTMGYTCDRR AQYITDGDVC
IQAFLVCCTE MASKKTESKQ DALLLSRSEE DDDDEYMRSE DIVSRSQFPE SWMWEDTTLP
ECPDQDKHCD STSVIRNNFL KDSITTWQIT AISLSKTHGI CVADPFEMIV LKEFFIDLKL
PYSAVRNEQL EVKAILHNYS EDPITVRVEL MENGEVCSSA SKKGKYRQEV NMDAMSTRVV
PYVIIPMKLG MHSIEVKASV KNSGSNDGVK RDLRVVAEGV LVKKETNVLL NPAKHGGEQT
SHIPSGVPRN QVPNSEADTL ISVTGGEQTS VLVEQAISGD SLGSLIVQPV GCGEQNMIYM
TLPVIATHYL DNTKKWEDIG LDKRNTAIKY INIGYQRELA YRKEDGSYAA WVQRQSSTWL
TAYVVKVFAM SSTLISVQEN VLCSAVKWLI LNTQQPDGIF NEFAPVIHAE MTGNVRGSDN
DASMTAFVLI AMQEASLLCE QSVNSLPGSM VKAVAYLEKR LPHLTNPYAV AMTSYALANA
EKLNKETLLK FASPQLDHWP VPGGHQYTLE ATSYALLALV KVKAFEEAGP VVRWLNKQKK
VGGGYGSTQS TIMVFQAVAE YWSHVKDLKD FDLDINLEVA GRASVTKWSI NNKNQFHTRT
DKVKSIDKDL TVKASGNGEA TLSVVTLYYA LPEEKDSDCE SFDLSVTLT
//
