ID A0A1S3QZ37_SALSA Unreviewed; 1748 AA.
AC A0A1S3QZ37;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Kinesin-like protein KIF1A isoform X1 {ECO:0000313|RefSeq:XP_014045373.1};
GN Name=LOC106598877 {ECO:0000313|RefSeq:XP_014045373.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014045373.1};
RN [1] {ECO:0000313|RefSeq:XP_014045373.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014045373.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR RefSeq; XP_014045373.1; XM_014189898.1.
DR STRING; 8030.ENSSSAP00000085559; -.
DR PaxDb; 8030-ENSSSAP00000085559; -.
DR GeneID; 106598877; -.
DR KEGG; sasa:106598877; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000087266; Chromosome ssa03.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..356
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 1634..1732
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1006..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 476..503
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 679..728
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1013..1034
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 96..103
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1748 AA; 197167 MW; B09A4EED6D59CF16 CRC64;
MAGASVKVAV RVRPFNSREI GKESKCIIQM TGNTTTILNP KQPKENKSFN FDYSYWSHTT
PDDINYHSQK QVYKDIGEEM LLHAFEGYNV CIFAYGQTGS GKSYTMMGKQ DQKDQQGIIP
LLCEDLFTKI SDSNTDNSLS YSVEVSYMEI YCERVRDLLN PKNKGNLRVR EHPLMGPYVE
DLSKLAVTSY NDIQDLMESG NKARTVAATN MNETSSRSHA VFNIIFTQKK HDMDSENTSE
KVSKISLVDL AGSERADSTG AKGTRLKEGA NINKSLTTLG KVISALAEVD SAPNKNKKKK
KVESHIPYRD SVLTWLLREN LGGNSRTAMV AALSPADINY DETLSTLRYA DRAKQIRCNA
VINEDPNNRL VRELKEEVCR LKDLLYAQGL GDIIDTYRCP GPVIAGLKTF QPGDYAANLC
DYNNFVNNRQ AVNQMGDLST VTNAMTGMSP SPSLSALSSR AGSMANLHDR IFSPASEEAI
ERLKETEKII AELNETWEEK LRRTEDIRMQ REALLAEMGV AMREDGGTVG VFSPKKTPHL
VNLNEDPLMS ECLLYYIKDG TTKVGREDAR SRQDIVLSGH FIQGEHCTFS STTGPGGEDD
DDTGNVILEP CEGAEIYVNG KLVTTPTLLR SGNRIIMGKS HVFRFNDPEQ ARQERERTPC
AETPVEPVDW AFAQRELLEK QGIDMKQEME SRLQELEDQY RREREEASNL LEQQRLDYES
KLEALQKQVD RNSRCLDPPE EEEEPEEEVF PIVPWTKCET ELALWAFRKW RFYQFTSLRD
LLWGNAIFLK EANAISVELK KKVQFQFVLL TDTLYSPLPP DLLPPSLTKE RERQPFPRTI
VAVEVQDQKN GATHYWTLEK LRQRLDLMRE MYDRAAEVPS STVEDCDQAL TGGDPFYDRF
PWFRLVGRAF VYLSNLLYPV PLVHRVAIVS EKGEVKGFLR VAVQAISADE EAPDYGSGVR
QSGTAKISFE DQQFEKVESF QTESCSSSMS HSNTSQEELR FVEGEGQTSD IGADPDEVNN
NTCADLSPIT ATPEAPQSPL KGVLGLELPL ELNQEKALSH LRIGSIFTFR VTVLQASSIS
AEYADIFCQF NFIHRHDEAF STEPLKNTGR GPPLGFYHVQ NITVEVTKSF VEYIKTQPIV
FEVFGHYQKQ PFPPLCKDLI SSHFFYSPLR PSRRQFPRVM PLSKPVPATK LNTLTRSTAG
PCHSKYDLMA FFEICELEAN GDYIPSVVDH RGGMPCHGTF LLHQGIQRRI TVTIAHETGN
DVEWKEVKEL VVGRIRNTPE ADETIIDPNI LSLNILSAGY VWPSYDDNVS LGVDHRTFYR
FEAAWDSSMH NSLLLNRVTP YGEKIYITLS AYLEMENCTQ PTVITKDFCM VFYSRDAKLP
ASRSIRNLFS TGCLRPSESN RVTGVYEVSL CHVADAGSPG MQRRRRRVLD TSVAYVRGEE
NLAGWRPRSD SLILDHQWEL EKLSLLQEVE KTRHYLLLRE KLEATLAAGQ DALCKSGDIS
DFAKSPILSY SPGGSPALES PSQRQRELAA KCLRLLMHTF NREYSQVSSS ASESKLSEMS
ASLMSPSSSG LSTLTPSSTC PSLVEGHYDI RHIEPSSGAS TPDLDPFSPV DRKRIPGRGC
TFVPDIQEIR VSPIVSKKGY LHFLEPHTSG WVKRYVVVRR PYVYLYRNDR DNVERAVINL
SSAQVEYSED KQTLLRTPNT FAVCTEHRGI LLQASNDKEM HDWLYAFNPL LAGTIRSKLS
RRKSGPRM
//
