ID A0A1S3R850_SALSA Unreviewed; 519 AA.
AC A0A1S3R850;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Sorting nexin-8 isoform X1 {ECO:0000313|RefSeq:XP_014048540.1};
GN Name=snx8 {ECO:0000313|RefSeq:XP_014048540.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014048540.1};
RN [1] {ECO:0000313|RefSeq:XP_014048540.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014048540.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_014048540.1; XM_014193065.1.
DR AlphaFoldDB; A0A1S3R850; -.
DR STRING; 8030.ENSSSAP00000030438; -.
DR PaxDb; 8030-ENSSSAP00000030438; -.
DR GeneID; 106601123; -.
DR KEGG; sasa:106601123; -.
DR OMA; ETTICER; -.
DR OrthoDB; 5475877at2759; -.
DR Proteomes; UP000087266; Chromosome ssa03.
DR Bgee; ENSSSAG00000034005; Expressed in semen and 13 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro.
DR CDD; cd07597; BAR_SNX8; 1.
DR CDD; cd06866; PX_SNX8_Mvp1p_like; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR028662; SNX8/Mvp1.
DR InterPro; IPR035704; SNX8/Mvp1_PX.
DR InterPro; IPR045734; Snx8_BAR_dom.
DR PANTHER; PTHR46571; SORTING NEXIN-8; 1.
DR PANTHER; PTHR46571:SF1; SORTING NEXIN-8; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF19566; Snx8_BAR_dom; 1.
DR SMART; SM00312; PX; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 130..245
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
SQ SEQUENCE 519 AA; 59502 MW; AE994EE5D0B34CB2 CRC64;
MAGELNEGSV PPYYREVYEA IRSKIDERVQ VEVFQRLLSR TDLPSAVQGQ IAEHVDYTDG
FLSKLSLYKA LALIALAQQG KQPSLKLLKN CIQEFPKPQL GEFKDLQTLR MQPTQESPLT
VSQTLGKLLA RDTVQVELIP EKKGLFLKHV EYQITSQHFK ISVYRRYSDF DVFHELLLQR
FAYRMVPALP PKRMLKGVLA SMSERDFIEG RRRALGRFIN LVARHPFFSE DELVKTFLTF
NGSDVQVKMR DTCKKMGDEF MTNTMASLAK EYLPADIQAQ FSSSRELIRN IHNSFHKLRD
RAEKMAERSK ENATDLLMFG RELSTLGSDG SPIPSLASSQ STWGILRQSL KGLSVEFALL
ADKGAQQGRR EEDDVVEKLN LFLDLLQSYR DLCERHEKGV LHEHQRALQK YGMMKRQMMS
ATVQPKEQVS VEQLESRIVQ QENAIQTMEL RNYFSLFCLH QETQLIFTYL PITSHILGAF
VNSQVQGHQE MGAVWNDLQQ KLGCLFGVDE MQSPPLTPK
//
