ID A0A1S3R932_SALSA Unreviewed; 1080 AA.
AC A0A1S3R932;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|RuleBase:RU361133};
GN Name=LOC106601024 {ECO:0000313|RefSeq:XP_014048352.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014048352.1};
RN [1] {ECO:0000313|RefSeq:XP_014048352.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014048352.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
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DR RefSeq; XP_014048352.1; XM_014192877.1.
DR AlphaFoldDB; A0A1S3R932; -.
DR GeneID; 106601024; -.
DR OrthoDB; 2900494at2759; -.
DR Proteomes; UP000087266; Chromosome ssa03.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd00275; C2_PLC_like; 1.
DR CDD; cd16206; EFh_PRIP; 1.
DR CDD; cd13364; PH_PLC_eta; 1.
DR CDD; cd08597; PI-PLCc_PRIP_metazoa; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR015359; PLC_EF-hand-like.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR001711; PLipase_C_Pinositol-sp_Y.
DR PANTHER; PTHR10336:SF85; PHOSPHOINOSITIDE PHOSPHOLIPASE C; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF09279; EF-hand_like; 1.
DR Pfam; PF16457; PH_12; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00387; PI-PLC-Y; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR SMART; SM00239; C2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00149; PLCYc; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50008; PIPLC_Y_DOMAIN; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transducer {ECO:0000256|ARBA:ARBA00023224}.
FT DOMAIN 15..125
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 492..608
FT /note="PI-PLC Y-box"
FT /evidence="ECO:0000259|PROSITE:PS50008"
FT DOMAIN 608..737
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 973..1035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1047..1080
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1080 AA; 122150 MW; 31F74C632BE331D5 CRC64;
MPNDRKINST AACMAFMMEG CEMKKVRSNS RMYNRYFLLD PDMHWLRWEP SKKDSEKAKL
EIKSIKEVRL GKKTPVLRSN GLSDQFPDEC AFSIIYGDNY ESLDLVASTA DVVSTWVMGL
RYLVSYGRHT VDVVEPSQPS LRTSWIGSVF ELADMERNGH IDLFRATQII KGLNPGMKES
RIELKFKELQ KAKDQYGEDI DMETFVEAYC ELCTRPEIFF LLVQFSSNKE YLDSKDLLLF
VEVEQGMEGV TEDMCRDIVQ KYEPSAEGRQ KASLSIDGFT HYLLSSECHI FDPQHKRVCQ
DMSQPLSHYY INSSHNASLL EDHFWGSSDI SSYIRTLKMG CRSLEVIVWD GPDNEPVVYV
GNSVASQLAL CKVLDIINQY AFESSEYPLI VCLVTHCCIP QQRVMAQHMK KILGDKLYLD
APSSEDHYLP SPEELKGKIL LKGKRLPPNY PESEGEVTDE EEGLEMSRRV GADDKDHLNG
LSCKRLRLCK ELSDLVSLCK SVQFRDFDIS KRDQKYWEMC SFNEVDANRF ANEFPEDFVC
YNKRFLSRVY PTPMRIDASN MNPQDFWKCG CQIVAMNYQT PGLMMDLNLG WFRQNGNCGY
VLRPAIMREE VSYFSANARE SLPGVSAQLL HIKVISGQNL PKPRGSAAKG DVVEPYIYAE
IHGIPADCAE QRTKTVSQNG DNPVFDESFE FQINLPELAA LRFVVLDDDY IGDEFIGQYT
IPFECLQPGY RHVPLQSLTG EFLPNCTLFV HVAITNRRGG GKAHKRGLSV RKGKKAREYT
SSKTTGIKVV DELFRASTQP LREATDLREN VQNAMVSFKE LCGLTPAANM KQCILTVSTW
LMNSERALRV TVDLSQAYPT MEAQGPVPEL LRKVLNAYNM MIQTSRTLIE SADVVYSKLT
QAQRAGLDFH VDLHRIGAKE GLKGRKLQKA MESYAWNITV LKGQADLLKH AKSEALDTLR
QIHCATQSCG LSKNGATSPQ LQHPPLQAQA QYQAQPHHSP QSHHLQPQAQ TQPQAQPLSQ
HLAEPQPEAQ SQLQAQLHTQ HHPLTQRLLL PPLPPQPPQY RAAGSHDAIS ENETASDGSC
//
