ID   A0A1S3R9C4_SALSA        Unreviewed;       598 AA.
AC   A0A1S3R9C4;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000256|RuleBase:RU368069};
DE   AltName: Full=Nitrogen permease regulator 3-like protein {ECO:0000256|RuleBase:RU368069};
GN   Name=LOC106601082 {ECO:0000313|RefSeq:XP_014048462.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014048462.1};
RN   [1] {ECO:0000313|RefSeq:XP_014048462.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014048462.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: As a component of the GATOR1 complex functions as an
CC       inhibitor of the amino acid-sensing branch of the TORC1 pathway.
CC       {ECO:0000256|RuleBase:RU368069}.
CC   -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|RuleBase:RU368069}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000256|ARBA:ARBA00010546,
CC       ECO:0000256|RuleBase:RU368069}.
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DR   RefSeq; XP_014048462.1; XM_014192987.1.
DR   AlphaFoldDB; A0A1S3R9C4; -.
DR   GeneID; 106601082; -.
DR   OrthoDB; 8983at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa03.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IEA:UniProtKB-UniRule.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; CGTHBA PROTEIN -14 GENE PROTEIN; 1.
DR   PANTHER; PTHR13153:SF5; GATOR COMPLEX PROTEIN NPRL3; 1.
DR   Pfam; PF03666; NPR3; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
PE   3: Inferred from homology;
KW   Lysosome {ECO:0000256|RuleBase:RU368069};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Signal {ECO:0000256|RuleBase:RU368069}.
FT   REGION          469..507
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        469..498
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   598 AA;  67361 MW;  3B5CB2114BB96710 CRC64;
     MYIHSSSFDL QGERKSMYKQ SENRFFKCGE KTSPISVILV TSGSRGNKLL FRYPFQRVAD
     CTSSLTTKQR SPYALNTTGD VLEDPDGDSR FSDIILATIL ATKSDMCGKK FELKIDNVRF
     VGHPTLLQHP HTIQVSKTDP SPKREMPTMI LFSVVFALRA NADPSVISCM HNLSRRIAIA
     LQHEERRCQY LTREAKLMLA VQDEVTNMTE TDGSPQSPFR QILPKCKLAR DLKEAYDSLC
     TTGVVRLHIN NWLEVSFCLP HKIHRVGGNH VPPEALERSL KAIRPYHALL LLDSEKALLA
     QLPLDCSPAL VRLIKTCSAV KNLQQLAQDA DLNLLQIFQI AAHLVYWGKA IIVYPLCENN
     VYMLSPHANI SLYSPLAEAF GQQFPGHDLP SMLAKFSLPL SLSEFRNPLD ASVQEAQLIQ
     MVVWMLQRRL LIQLHTYVCL LVPPSEEEPG LLRDEELPLV ARVGGRSLST PSALSFGSPT
     SSDDMTLTSP SMDNSSAELL PGGDSPLNRR MTETLLASLT EHERQVILNI PAAQSPEDLR
     MFARLLHYFR GHHHLEEIMY NENMRRSQLK TLFDKFRSVL VVTNHEDPVI SLFQSPLE
//