ID   A0A1S3RBZ1_SALSA        Unreviewed;       989 AA.
AC   A0A1S3RBZ1;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Neuronal PAS domain-containing protein 3 isoform X4 {ECO:0000313|RefSeq:XP_014049883.1};
GN   Name=npas3 {ECO:0000313|RefSeq:XP_014049883.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014049883.1};
RN   [1] {ECO:0000313|RefSeq:XP_014049883.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014049883.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014049883.1; XM_014194408.1.
DR   AlphaFoldDB; A0A1S3RBZ1; -.
DR   GeneID; 106601938; -.
DR   OrthoDB; 5396877at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa01.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd19731; bHLH-PAS_NPAS1_PASD5; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF30; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          83..136
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          185..249
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          367..422
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          53..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          247..287
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          483..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..287
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..531
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        555..570
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        571..606
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..628
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        644..660
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        664..685
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        704..756
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        776..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   989 AA;  108375 MW;  2BE148E6719FC734 CRC64;
     MAPTKPSIQQ DPTRREREIK TLHPFCMEGS EEEAVVDAQF MSKFPHDPYW ERPANTSSCS
     ASRPKTLHLG GQQHTSSPWL QALRKEKSRD AARSRRGKEN FEFYELAKML PLPGAITSQL
     DKASIIRLTI SYLKMRDFAN QGDPPWNLRI EGPPPNTSVK AIGVQRRRTP SAVASEIFEP
     HLGSHILQSL DGFVFALNKE GRFLYISETV SIYLGLSQVE LTGSSVFDYV HPGDHVEMAE
     QLGMKLPPGR GLLSQGTATE DGASSASSSS HAETPEPVES TSPSLLSPDN TLERSFFIRM
     KSTLTKRGVH IKSSGYKVIH VTGRLRIRMA LTHSRSVPIQ IMGMVVVAHA LPPPTINEVR
     IDCQMFVTRV NMDLNIVYCE NRISDYMDLT PLDIVGKRCY QFIHAEDVEG IRHSHLDLIN
     KGQCVTKYYR WIQKNGGYIW IQSSATIAIN AKNANEKNII WVNYVLSNPE YKDTPMDIAQ
     LPNLPEKASE SSETSDSESE SKENSEDNEN SKSDGKGNQT ENSEDPETDS KKQQQGQSSS
     EQEMRRQEEG DSSSNPESQE SEDDLEPSDC ELETKESRLG RLGGLHIKVE HYGDRDGRVE
     LHNSPSSSEE EEDDDDDEED DDDDDSVKDC DRATEMLAAP AASKQQKRKK RRKKQKWDGS
     RSRRLRLSSA TTSPGTMNHP TLLLPPSPAS ASVLKIKTEM SEPINFDNDS SIWNYPPNRE
     ISRNESPYSM TKHVPTHDTF PSPQPGSLQV SIPDSVLTPP GTEGGGGGGG TRKGVPPSFN
     GNSSAPSSAS SVASLAPPSS SGSSSDPLSP PLSASPRDKQ QGQGTPTTSN SSSSLLYTSD
     LEALQRLQAG NVVLPLVHRV TGTLATTSTA ASRVYTTGTI RYAPADVTLA MQAGANLLPN
     NVAHAMNFVD VNGSPGFGID PKTPMEMLYH HVHRLNMAGP FGGAVSGASL TQMPATNVFT
     TAEGLFSTLP FPVYSNGIHT TQTLERKED
//