ID   A0A1S3RBZ3_SALSA        Unreviewed;      1022 AA.
AC   A0A1S3RBZ3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Neuronal PAS domain-containing protein 3 isoform X2 {ECO:0000313|RefSeq:XP_014049875.1};
GN   Name=npas3 {ECO:0000313|RefSeq:XP_014049875.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014049875.1};
RN   [1] {ECO:0000313|RefSeq:XP_014049875.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014049875.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_014049875.1; XM_014194400.1.
DR   AlphaFoldDB; A0A1S3RBZ3; -.
DR   OrthoDB; 5396877at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa01.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd19731; bHLH-PAS_NPAS1_PASD5; 1.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   InterPro; IPR013655; PAS_fold_3.
DR   PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR   PANTHER; PTHR23043:SF30; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 3; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF08447; PAS_3; 1.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266}.
FT   DOMAIN          117..170
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          219..283
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          401..456
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          16..42
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          87..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          281..321
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          517..721
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          737..867
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        291..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        525..544
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        588..603
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        604..639
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        640..661
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        677..693
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        697..718
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..789
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        809..867
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1022 AA;  111395 MW;  3E22E8D215D171D0 CRC64;
     MIRIFPDFSV QVTAAGGGAG GMPSGPAVGR IPGTTNGNPQ NVQGITSYQQ REIKTLHPFC
     MEGSEEEAVV DAQFMSKFPH DPYWERPANT SSCSASRPKT LHLGGQQHTS SPWLQALRKE
     KSRDAARSRR GKENFEFYEL AKMLPLPGAI TSQLDKASII RLTISYLKMR DFANQGDPPW
     NLRIEGPPPN TSVKAIGVQR RRTPSAVASE IFEPHLGSHI LQSLDGFVFA LNKEGRFLYI
     SETVSIYLGL SQVELTGSSV FDYVHPGDHV EMAEQLGMKL PPGRGLLSQG TATEDGASSA
     SSSSHAETPE PVESTSPSLL SPDNTLERSF FIRMKSTLTK RGVHIKSSGY KVIHVTGRLR
     IRMALTHSRS VPIQIMGMVV VAHALPPPTI NEVRIDCQMF VTRVNMDLNI VYCENRISDY
     MDLTPLDIVG KRCYQFIHAE DVEGIRHSHL DLINKGQCVT KYYRWIQKNG GYIWIQSSAT
     IAINAKNANE KNIIWVNYVL SNPEYKDTPM DIAQLPNLPE KASESSETSD SESESKENSD
     NENSKSDGKG NQTENSEDPE TDSKKQQQGQ SSSEQEMRRQ EEGDSSSNPE SQESEDDLEP
     SDCELETKES RLGRLGGLHI KVEHYGDRDG RVELHNSPSS SEEEEDDDDD EEDDDDDDSV
     KDCDRATEML AAPAASKQQK RKKRRKKQKW DGSRSRRLRL SSATTSPGTM NHPTLLLPPS
     PASASVLKIK TEMSEPINFD NDSSIWNYPP NREISRNESP YSMTKHVPTH DTFPSPQPGS
     LQVSIPDSVL TPPGTEGGGG GGGTRKGVPP SFNGNSSAPS SASSVASLAP PSSSGSSSDP
     LSPPLSASPR DKQQGQGTPT TSNSSSSLLY TSDLEALQRL QAGNVVLPLV HRVTGTLATT
     STAASRVYTT GTIRYAPADV TLAMQAGANL LPNNVAHAMN FVDVNGSPGF GIDPKTPMEM
     LYHHVHRLNM AGPFGGAVSG ASLTQMPATN VFTTAEGLFS TLPFPVYSNG IHTTQTLERK
     ED
//