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Database: UniProt
Entry: A0A1S3RFG8_SALSA
LinkDB: A0A1S3RFG8_SALSA
Original site: A0A1S3RFG8_SALSA 
ID   A0A1S3RFG8_SALSA        Unreviewed;      1995 AA.
AC   A0A1S3RFG8;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   31-JUL-2019, entry version 18.
DE   SubName: Full=endoribonuclease Dicer-like isoform X1 {ECO:0000313|RefSeq:XP_014050520.1, ECO:0000313|RefSeq:XP_014050529.1, ECO:0000313|RefSeq:XP_014050540.1};
GN   Name=LOC106602420 {ECO:0000313|RefSeq:XP_014050520.1,
GN   ECO:0000313|RefSeq:XP_014050529.1, ECO:0000313|RefSeq:XP_014050540.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014050529.1};
RN   [1] {ECO:0000313|RefSeq:XP_014050520.1, ECO:0000313|RefSeq:XP_014050529.1, ECO:0000313|RefSeq:XP_014050540.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014050520.1,
RC   ECO:0000313|RefSeq:XP_014050529.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the helicase family. Dicer subfamily.
CC       {ECO:0000256|PROSITE-ProRule:PRU00657}.
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DR   RefSeq; XP_014050520.1; XM_014195045.1.
DR   RefSeq; XP_014050529.1; XM_014195054.1.
DR   RefSeq; XP_014050540.1; XM_014195065.1.
DR   GeneID; 106602420; -.
DR   KEGG; sasa:106602420; -.
DR   KO; K11592; -.
DR   OrthoDB; 1337630at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd00048; DSRM; 1.
DR   CDD; cd00593; RIBOc; 2.
DR   Gene3D; 1.10.1520.10; -; 1.
DR   Gene3D; 3.30.160.380; -; 1.
DR   InterPro; IPR038248; Dicer_dimer_sf.
DR   InterPro; IPR005034; Dicer_dimerisation_dom.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003100; PAZ_dom.
DR   InterPro; IPR036085; PAZ_dom_sf.
DR   InterPro; IPR000999; RNase_III_dom.
DR   InterPro; IPR036389; RNase_III_sf.
DR   Pfam; PF03368; Dicer_dimer; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF02170; PAZ; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF00636; Ribonuclease_3; 2.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00358; DSRM; 1.
DR   SMART; SM00490; HELICc; 1.
DR   SMART; SM00949; PAZ; 1.
DR   SMART; SM00535; RIBOc; 2.
DR   SUPFAM; SSF101690; SSF101690; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   SUPFAM; SSF69065; SSF69065; 2.
DR   PROSITE; PS51327; DICER_DSRBF; 1.
DR   PROSITE; PS50137; DS_RBD; 1.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
DR   PROSITE; PS50821; PAZ; 1.
DR   PROSITE; PS00517; RNASE_3_1; 1.
DR   PROSITE; PS50142; RNASE_3_2; 2.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266};
KW   RNA-mediated gene silencing {ECO:0000256|SAAS:SAAS00703041}.
FT   DOMAIN       41    217       Helicase ATP-binding.
FT                                {ECO:0000259|PROSITE:PS51192}.
FT   DOMAIN      423    592       Helicase C-terminal.
FT                                {ECO:0000259|PROSITE:PS51194}.
FT   DOMAIN      620    712       Dicer dsRNA-binding fold.
FT                                {ECO:0000259|PROSITE:PS51327}.
FT   DOMAIN      881   1032       PAZ. {ECO:0000259|PROSITE:PS50821}.
FT   DOMAIN     1363   1439       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1739   1897       RNase III. {ECO:0000259|PROSITE:PS50142}.
FT   DOMAIN     1922   1987       DRBM. {ECO:0000259|PROSITE:PS50137}.
FT   REGION      717    736       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1099   1182       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1210   1352       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1457   1478       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   REGION     1549   1595       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COILED     1479   1499       {ECO:0000256|SAM:Coils}.
FT   COMPBIAS   1103   1122       Acidic. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1154   1174       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1224   1272       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1273   1287       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1291   1305       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1306   1349       Polar. {ECO:0000256|SAM:MobiDB-lite}.
FT   COMPBIAS   1458   1478       Polyampholyte. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
FT   COMPBIAS   1573   1587       Pro-rich. {ECO:0000256|SAM:MobiDB-lite}.
SQ   SEQUENCE   1995 AA;  225684 MW;  C75565C4EE92D0BE CRC64;
     MSGLQLVTPA SNPMGPFFGL PWQQEAIHDN IYTPRKYQVE LLEAALEHNT IVCLNTGSGK
     TFIAVLLTKE LSHQIRGDFA EHGKRTVFLV NTESSVIQQA ASVRTHSDLQ VGEYTSAEKI
     SSWSGEKWSQ EMIENQVLVM TCHIFLHVLK NGVLPLWKLN LVVFDECHLA ITDHPYREIM
     KLCEGSLCSP RILGLTASIL NGKCDPSELE QKIQNLERIL RSNAETATDL VVLDRYASQP
     REVVLDCGPY LDKSGLSECL LSELDKALHF LNDCNISVPR EDRDPTFITK QVLRDCRAVL
     LVLGPWCADK VAGIMVRELQ KYIKHEQEEI NRKFLLFTDT ILRKVHALCE EHFTPASLDL
     KFVTPKVIRL LEILHEYKPF ERQQFESVEW YNNRNEDNYV SWSDSEDEDE DEEVEVKEKP
     EAIFPSPFTN ILCGIIFVDR RYTAVVLNRL IKEAGKQDTE LAYISSNFIT GHSIGKNQPR
     NKQMEVEFRK QEEVLRKFRA HETNLLIATS IVEEGVDIPK CNLVVRFDLP TEYRSYVQSK
     GRARAPVSNY IMLADSERAK TFEDDLKTYK AIEKILRNKC SKAAGVGEFE VEQVLDDDNI
     LPPYVLRSED AGPRVTINTA IGHINRYCAR LPSDPFTHLA PKCKTKELQD GRYQSTLYLP
     INSPLRVPVA GPTMNCARLA EKAVALLCCE KLHKKGELDD HLMPVGKETV KYEEELDLHD
     EEETSVPGRP GSTKRRQCYP KAIPECLRDS YPVPQQSYYL YVVGMVLTTP LPDELNFRRR
     KLYPPEDTTR CFGILTAKPI PRIPHFPVYT RSGEVTISIE LQKAGFTLSA IQLDLITRLH
     QYIFSHILRL EKPALEFKPT QADSAYCVLP LNVVEDSITL ALDFKFMEDI EKSEARTGIP
     TTLYTKQNPF TFKLEDYQDA VIIPRYRNFD QPHRFYVADV YTDLTPLSKF PSPEYETFAE
     YYKTKYNLDL SNVNQPLLDV DHTSSRLNLL TPRHLNQKGK ALPLSSAEKR KAKWESLQNK
     QILVPELCAI HPIPASLWRK AVCLPSILYR LHCLLTAEEL RAQTASDAGV GAQTLPPDFR
     YPNLDFGWKK SIDSKSFICP RDEEEYDDDD DDDDDDVEEE DSVDENCKHH GQTAAPDPAV
     AQQPFSDCHV SSQPERGDVS KHQEADRLEE EEPQQPDSAS CTNTLTNCTA AVAKDNSDYG
     DHAHLHDGRD NCQFLPAGPG SPLESEEVST TMTTQTTTSV HPVQPSPSTE NQNLTPTQPR
     TQSQLQHPQP RTQPQPWTQP RPPQPSDECK PRGTTELREG DGHHVNQATS DSCSPATVTW
     PKGTAPITTT APLHDYSKTQ ETSYTEGDTP GPCPKTLGPN PGLILQALTL SNASDGFNLE
     RLEMLGDSFL KHAITTYLFC TYPDAHEGRL SYMRSKKVSN CNLYRLGKKK GLPSRMVVSI
     FDPPVNWLPP GYVVNQDESS EDKWDETKVD PLDNGSAGKE LCEDEVELEE ELLEEDEDLM
     WKESKEEVNI EDDLEYYQEH IKFIDNMLMG SGAFGKKISL RTFPAALATP APGPSPSARS
     SSPAAEPSFG VWKPPKKPGP VPTPDYPSEP GGGGSADEFD YSSWDAMCYL DPSKAGEEDD
     FVVGFWNPSE ENCGVELAKQ SISYNLHTEQ CIADKSIADC VEALLGCYLT SCGERAAQMY
     LCSLGLKVLP VESRTLREEG RVTEVANLDL QYGWLKIPHR CMFDHPDAER TLNHLISGFE
     NFERKISYTF QNKAYLLQAF THASYHYNTI TDCYQRLEFL GDAILDYLIT KHLYEDPRQH
     SPGVLTDLRS ALVNNTIFAS LAVQYDYHKY FKAVSPELFH VIDDFVQFQL EKKEMQGMDS
     ELRRSEEDEA KEEDIEVPKA MGDIFESLAG AIYMDSRMSL ETVWQVYYPM MRPLIEKFSA
     NVPRSPVREL LEMEPETAKF SPAERTYDGK VRVTVEVVGK GKFKGVGRSY RIAKSAAARR
     ALRSLKANQP QVPNN
//
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