ID A0A1S3RFI3_SALSA Unreviewed; 293 AA.
AC A0A1S3RFI3;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Secreted frizzled-related protein 2-like {ECO:0000313|RefSeq:XP_014051063.1};
GN Name=LOC106602749 {ECO:0000313|RefSeq:XP_014051063.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051063.1};
RN [1] {ECO:0000313|RefSeq:XP_014051063.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051063.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the secreted frizzled-related protein (sFRP)
CC family. {ECO:0000256|ARBA:ARBA00010054}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR RefSeq; XP_014051063.1; XM_014195588.1.
DR AlphaFoldDB; A0A1S3RFI3; -.
DR STRING; 8030.ENSSSAP00000010091; -.
DR PaxDb; 8030-ENSSSAP00000010091; -.
DR GeneID; 106602749; -.
DR KEGG; sasa:106602749; -.
DR CTD; 6423; -.
DR OMA; NFGQHDL; -.
DR OrthoDB; 4814466at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR Bgee; ENSSSAG00000005040; Expressed in nose and 4 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd07446; CRD_SFRP2; 1.
DR CDD; cd03580; NTR_Sfrp1_like; 1.
DR Gene3D; 2.40.50.120; -; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR001134; Netrin_domain.
DR InterPro; IPR018933; Netrin_module_non-TIMP.
DR InterPro; IPR041764; SFRP2_CRD.
DR InterPro; IPR008993; TIMP-like_OB-fold.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF45; SECRETED FRIZZLED-RELATED PROTEIN 2; 1.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF01759; NTR; 1.
DR SMART; SM00643; C345C; 1.
DR SMART; SM00063; FRI; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF50242; TIMP-like; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50189; NTR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090}; Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP};
KW Wnt signaling pathway {ECO:0000256|ARBA:ARBA00022687}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..293
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010313866"
FT DOMAIN 33..153
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 170..293
FT /note="NTR"
FT /evidence="ECO:0000259|PROSITE:PS50189"
FT DISULFID 48..94
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 85..123
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 116..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 293 AA; 33663 MW; AD0573D1BF2B861B CRC64;
MNYYILSLIW AITLPACMAI HGLYNFGQPE LFYKKNNCKP IPANLLLCHD IEYTEMRLPN
LLGHETMNEV LQQASSWIPL VQKQCHPDTR KFLCSLFAPV CLDDLDEPIQ PCRSLCESVK
HGCAPVMSAF GFPWPDMLDC ERFPPDNDLC IPPAGIDHFM PVTKEVPRVC DACKEKEEND
NEIVDNLCKN DFALKIKVKE ISYMNGDTKI VPETKSKTIY KLSGVTERDL RKTVLWLKDG
LQCVCDEMND INASYLVMGQ KMDGHLVITS LKRWQRGQRE FKRISRSIRK LQC
//
