ID A0A1S3RGS8_SALSA Unreviewed; 397 AA.
AC A0A1S3RGS8;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Suppressor of cytokine signaling 4 {ECO:0000313|RefSeq:XP_014051425.1, ECO:0000313|RefSeq:XP_014051434.1};
GN Name=socs4 {ECO:0000313|RefSeq:XP_014051425.1,
GN ECO:0000313|RefSeq:XP_014051434.1, ECO:0000313|RefSeq:XP_014051441.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051441.1};
RN [1] {ECO:0000313|RefSeq:XP_014051425.1, ECO:0000313|RefSeq:XP_014051434.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051425.1,
RC ECO:0000313|RefSeq:XP_014051434.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_014051425.1; XM_014195950.1.
DR RefSeq; XP_014051434.1; XM_014195959.1.
DR RefSeq; XP_014051441.1; XM_014195966.1.
DR STRING; 8030.ENSSSAP00000101263; -.
DR PaxDb; 8030-ENSSSAP00000101263; -.
DR GeneID; 106602930; -.
DR KEGG; sasa:106602930; -.
DR CTD; 122809; -.
DR OMA; KCDGACA; -.
DR OrthoDB; 5362214at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000087266; Chromosome ssa01.
DR Bgee; ENSSSAG00000074782; Expressed in sexually immature organism.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF35; SUPPRESSOR OF CYTOKINE SIGNALING 4 ISOFORM X1; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 251..346
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 341..390
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 24..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..40
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 397 AA; 44824 MW; 65FD3615B8E7A27A CRC64;
MSEKKSQSSD TRSKCGIRSW SADSYVWSSK KRSRSSRNNP GLWGPEGEGP MDEQGVRSTS
CPWRQRERKC SCTVLGEIDT DVPCRKALSR RSLRQKFQDA VGQCFPLRNG HHHHHHHGHP
TGASRGAFSV LLWSKRKIHV SELMQDKCPF SPKSELAHCW HLIKKHATHP STIVGLETAQ
AAQASRAAST EQFPSTSPPS MPLSWEGICS SRPLSLEDWD PSCPQGGAAH GDSHTDYILV
PDLLQINNSP CYWGVLDRFE AEELLEGQPE GTFLLRDSAQ DEFLFSVSFR RYSRSLHARI
EQNGKRFSFD GRDPCMYRDP SVTGLLRHYS DPATCLFFEP LLALPLPRTF PFTLQHLCRA
VICSCTTYQG IEILPLPYQL RDYLSQYHYK CNGACAV
//
