ID A0A1S3RH14_SALSA Unreviewed; 135 AA.
AC A0A1S3RH14;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=CDGSH iron-sulfur domain-containing protein 2 {ECO:0000256|RuleBase:RU369084};
GN Name=LOC106602754 {ECO:0000313|RefSeq:XP_014051069.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051069.1};
RN [1] {ECO:0000313|RefSeq:XP_014051069.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051069.1};
RG RefSeq;
RL Submitted (JUN-2017) to UniProtKB.
CC -!- FUNCTION: Regulator of autophagy that contributes to antagonize BECN1-
CC mediated cellular autophagy at the endoplasmic reticulum. Participates
CC in the interaction of BCL2 with BECN1 and is required for BCL2-mediated
CC depression of endoplasmic reticulum Ca(2+) stores during autophagy.
CC {ECO:0000256|RuleBase:RU369084}.
CC -!- COFACTOR:
CC Name=[2Fe-2S] cluster; Xref=ChEBI:CHEBI:190135;
CC Evidence={ECO:0000256|RuleBase:RU369084};
CC Note=Binds 1 [2Fe-2S] cluster. {ECO:0000256|RuleBase:RU369084};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738,
CC ECO:0000256|RuleBase:RU369084}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU369084}; Single-pass membrane protein
CC {ECO:0000256|RuleBase:RU369084}. Mitochondrion outer membrane
CC {ECO:0000256|RuleBase:RU369084}; Single-pass membrane protein
CC {ECO:0000256|RuleBase:RU369084}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the CISD protein family. CISD2 subfamily.
CC {ECO:0000256|ARBA:ARBA00008624, ECO:0000256|RuleBase:RU369084}.
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DR RefSeq; XP_014051069.1; XM_014195594.1.
DR AlphaFoldDB; A0A1S3RH14; -.
DR SMR; A0A1S3RH14; -.
DR Ensembl; ENSSSAT00000010169; ENSSSAP00000009523; ENSSSAG00000004742.
DR GeneID; 106602754; -.
DR KEGG; sasa:106602754; -.
DR OMA; PKCDGSH; -.
DR OrthoDB; 1204967at2759; -.
DR Proteomes; UP000087266; Chromosome ssa04.
DR Bgee; ENSSSAG00000004742; Expressed in muscle tissue and 14 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR GO; GO:0010506; P:regulation of autophagy; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.5.90; CDGSH iron-sulfur domain, mitoNEET-type; 1.
DR InterPro; IPR045131; CISD1/2.
DR InterPro; IPR018967; FeS-contain_CDGSH-typ.
DR InterPro; IPR019610; FeS-contain_mitoNEET_N.
DR InterPro; IPR042216; MitoNEET_CISD.
DR PANTHER; PTHR13680; CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR13680:SF5; CDGSH IRON-SULFUR DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF10660; MitoNEET_N; 1.
DR Pfam; PF09360; zf-CDGSH; 1.
DR SMART; SM00704; ZnF_CDGSH; 1.
PE 3: Inferred from homology;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714, ECO:0000256|RuleBase:RU369084};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU369084};
KW Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU369084};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU369084};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU369084};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU369084};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00022787};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU369084};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU369084}.
FT TRANSMEM 38..56
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU369084"
FT DOMAIN 81..120
FT /note="Iron-binding zinc finger CDGSH type"
FT /evidence="ECO:0000259|SMART:SM00704"
SQ SEQUENCE 135 AA; 15542 MW; EEDF61AE3F7532E4 CRC64;
MVLETISRII KIQLPAYLKK LPLPETIGGF ARLTVSEWLR LLPLLGILAL LGYLTIRPFL
PKKKKQKDSL INLKIQKENP KVVNEIDIED LKRTNVCYCR CWRSKTFPVC DKSHIKHNEL
TGDNVGPLIL KKKIL
//
