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Database: UniProt
Entry: A0A1S3RHI3_SALSA
LinkDB: A0A1S3RHI3_SALSA
Original site: A0A1S3RHI3_SALSA 
ID   A0A1S3RHI3_SALSA        Unreviewed;      5094 AA.
AC   A0A1S3RHI3;
DT   12-APR-2017, integrated into UniProtKB/TrEMBL.
DT   12-APR-2017, sequence version 1.
DT   16-JAN-2019, entry version 9.
DE   SubName: Full=ryanodine receptor 1 isoform X12 {ECO:0000313|RefSeq:XP_014051743.1};
GN   Name=ryr1 {ECO:0000313|RefSeq:XP_014051743.1};
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii;
OC   Salmoniformes; Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014051743.1};
RN   [1] {ECO:0000313|RefSeq:XP_014051743.1}
RP   IDENTIFICATION.
RC   TISSUE=Muscle {ECO:0000313|RefSeq:XP_014051743.1};
RG   RefSeq;
RL   Submitted (JUN-2017) to UniProtKB.
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DR   RefSeq; XP_014051743.1; XM_014196268.1.
DR   GeneID; 106603084; -.
DR   CTD; 6261; -.
DR   OrthoDB; 5161at2759; -.
DR   Proteomes; UP000087266; Genome assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000087266};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|RefSeq:XP_014051743.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4364   4387       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4605   4625       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4699   4720       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4834   4854       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4894   4916       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4975   4998       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      588    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1347   1557       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      461    481       {ECO:0000256|SAM:Coils}.
FT   COILED     3709   3729       {ECO:0000256|SAM:Coils}.
FT   COILED     4541   4561       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5094 AA;  575733 MW;  DAD04BF81768EFC1 CRC64;
     MAEGGDGEEE IQFLRTDDQV VLQCTASILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLSNTMELNE SSQGGGHRTL LYGHAILLKH THSSMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDLIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWT MSPVMSGCEL AEGFLTGGYV LRLFHGHMDE CLAIPAAEQG
     DDQRRIAHYE GGAVCSHARS LWRLEPLRIG WSGGHMKWGQ SFRVRHITTG RYLCLDEEKG
     LLVVDPEKAN AKMSAFCFRI SKEKIEVAQK RDVEGMGTPE IKYGESMCFV QHVSSGLWLT
     YASVDAKSAR LGPLKRKAIL HKEGHMDDAL TVARSQTEEF QAARMIYNTA GLFTQFIKAL
     DSLSGKNKSS SGPPSLPMDS VALSLQDLIF YFRPPEEELE HEEKQTKLRS LKNRQNLFQE
     EGMITLVLDC IDRLNVYNTA AHFSEFAGEE AAESWKEIVN LLYELLASLI RGNRANCALF
     CDNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQNL ITENLLPGRD LLLQSNIINY VTSVRPNIFL GTCEGSTQYK
     KWYFEVMVDY VEPFLTAQAF HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LYSYAFDGLH
     LWSGRVLRHV ASPNMHILAA DDVVSCCLDL SVPSISFRIN GHPVQGMFEN FNLDGLFFPV
     VSFSAGVRVR FLLGGRHGDF KFLPPPGYAP CYEAVLPKDR LRIEPIKEYK HDFNGVRNLL
     GPTQSLSHTA FTPCPVDTVQ IVLPPHLERI REKLAENSHE LWAATRIEQG WTYGSFRDDN
     KKLHPCLVDF QSLPEPEKNY NLAMSGETLK TLLALGCHVG MGDEKAEENL KNIKMPKTYM
     MSSGYKPAPL DLNHVKLTPN QTNLVERLAE NGHNVWARDR VHQGWTYSIV QDIMSKRNPR
     LVPYNLLDEK TKKTNRDTVC AAVRTLIGYG YNIEPPDQES SGNGEGHSRG NKIRVFRAEK
     SYAVTQGKWY FEFEAVTVGD MRVGWARPSV RADTELGADE LAYVFNGFKA QRWHVGNEPF
     GRSWLPGDVV GCMIDLVEQN IFFTLNGEML ISDSGSEMAF KDIDTGDGFI PVCSLGLSQV
     GRLNLGQNVS SLRYFTICGL QEGFEPFAIN MKRDITMWFS KSLPQFIPVP TEHPHIEVSR
     VDGTVDSAPC LKLTHKTFGS QNANTDLLFL RLSMPVEFHE TFKVMAGTTP LTRALTIPED
     QVLEVDPDSD FEVLKKSASR TEKEEEKKEP SVPKEIPVNE GGENVKDAST EKSKKKGFLF
     KAKKAAFTPP PVVPTMPRLM EEVVPDDRDD DDIILNTTTY YYSVRVIAGQ EPSGVWVGWI
     TPDYHQYDLH FDLSKVRNVT VTVGDDKGNI HDSMKRSNCY MVWGGEFSSS QQTRVSQEDF
     VIGCLIDLDT GLMTFTANGK EINTFYQVEP NTKLFPAVFV LPSSQNMLQV ELGKLKNIMP
     ISAAMFRSER KNPVPQCPPR LDVQMLTPVI WSRMPNHFLS PETGRVNERH GWMVECREPL
     TMMALHIPEE NRCIDVLELS ERMDLLKFHY HTLKLYGSVC ALGNNRVAHA LCSHVDESQL
     FYAIENTYLP GPMRSGYYDL LISMHLESAK RNRLMTNKEF IVPMTDETRS INLYSDTDNS
     HALPGVGLTT CLRPKLHFSP TGFVGTDLDI YTLSPFIPLQ VLKAKALTML TEAVQDGGQA
     MRDPVGGSVE FHFVPILKLI STLLIMGVFE NEDVKHILKM IEPTVFSGEA EAAAEEAEAT
     AKGAGSQTLA LKEGGEEVKE EEEGAVESGH ETEMEDEGMG EEDEELEAEL EEPVEKEEEE
     EEEEEDGEKV DGEKGAEETE KEATPGEADG EAEEQVGLEE GLLHMKLPES VKLQMCTLLQ
     YFCDCELRHR VEAIIAFSDQ FVSQVQANQR ARYNELMLAF TMSAAETARK TREFRSPPQE
     QVNMLMNFKS IAEDEECPVP DEVRDALLSF HKNLLSHCGV HIEEEEVEEE LDMSLKGRLF
     RMLDKLRHLR KKKVEEEPEP VEETKPSTLQ ELISHTMIHW AQESFIQNPE LVRLMFSLLH
     RQYDGLGELI RALPKAYTIN AISIKDTMDL LECLGQIRSL LIVQMGPEEE RLMIQSIGNI
     MSNKVFYQHP NLMRALGMHE TVMEVMVNVL GGGDSKEIRF PRMVTNCCRF LCYFCRISRQ
     NQRSMFDHLS YLLQNSGIGL GMRGSTPLDV AAASCIDNNE LALALQEQDL EKVVKYLAGC
     GLQSCPQLLA KGYPDIGWNP CGGEKYLDFL RFAVFVNGES VEENANVVVR LLIRRPECFG
     PALRGEGGNG LLAAIEEAIK ISEDPARDGP TVKKDRRFPG MFPGGEEQHE ENKVHLGNAI
     MSFYSALIDL LGRCAPEMHL IQAGKGEALR IRAILRSLVP MEDLVGVISL SVQIPDFGKD
     NSVIEPKMSS SFVPDHKAPM VLFLDRVYGI DNQDFLLHVL EVGFLPDMRA AASLDTAAFC
     TTEMALALNR YLSLAVLPLI TKCAFLFAGT DHRAIMIDSM LHTIYRLSRG RAFTKAQRDV
     IEECLMALCK NLRPSMLQHL LRRLVFDVPI LNEYAKMPLK LLTNHYERCW KYYCLPNGWG
     NFGVSSEEEL HLTRKLFWGI FESLAHKKFD AELFKIAMPC ICAIAGAIPP DYVDASYSSK
     TEKKALVDAE GNFDPKPVET TNTIIPERLD GFINRYAEYT HDKWAFEKIQ NNWTYGEMLD
     ENSKTHPMLR PYKTFSEKDK EIYRWPIKES MKAMIAWEWT LDQTREGDEA KAELKKAARK
     ISQTAQATYD PSHGYSPQPI EISHMALSRE LQSMAEQLAE NYHNTWGRKK KMELQSKGGG
     AHPLLVPYDT LTAKEKARDR EKAHELLKFL QLNGFAVTRG MKDMESDISS IEKRFAYGFL
     QKLLKWMEIA QEFIAHLEAV VSSGRVEKSP HEQEIKFFAK ILLPLINQYF KNHCLYFLST
     PAKVLGSGGH SSNKEKEMIA SIFCKMAALV RHRVSLFGND AAAIVNCLHI LARSLDARTV
     MKSGPEIVKA GLRSFFEGAA DDIEKMVENL KLGKVSKGNQ QVKGVSQNIN YTTIALLPVL
     TSLFDHISQH QFGDDVMLDD LQMSCYRIMC AIYSLGSVKN PHVERQRPAL GECLAHLAAA
     MPVAYLEPHL NEYNAFSVYT TKTPRERAIL GLPNEVQELC QDIPELDVLL KEIGDLAESG
     ARYTEMPHVI EITLPMLCNY LPRWWERGVE NFPELEGQIC TDVTSDQLNQ LLGSIMKIVV
     NNLGIDEASW MKRLAVFSQP IVSRARPEML KSHFIPTMEK LKKRTGKVVA EEDHLRMEGK
     AEGDEEEGTI RDEFAVLCRD LYALYPLLIR YVDNNRARWL TCPDPDAEEL FRMVGEVFIF
     WSKSHNFKRE EQNFVVMNEI NNMSFLTADS KSKMSKGSDS EAGGSDVERT KKKRRGDRYS
     VQTSLIVAAL KKMLPIGLNM CSPADHELIN LAKIRYSLRD TDEEVREFLQ NNLHLQGKVE
     NPSMRWQMSL YKEMAGKAED ADAPEKVVKR VQEVSAVLYH IEVTEHPFKS KKMVWHKLLS
     KQRRKAVVAC FRMTPLYNLP RHRASNMFLE GYKRNWIHTE GYSFEDRMID DLSKAMEQEG
     EEEEETETKP DPLHQLILHF SRTALTEKSK LDTDYLYMAY ADIMAKSCHI GEEDEGGEEV
     EEGAEDEMSF EVRQTELEKE MEKQRLLYQQ SRLHNRGAAE MVLQMISACK GETGCMVSST
     LKLGISILNG GNVEVQQKML EYLKDKKDVG FFLSVQALMQ TCSVLDLNAF ERQNKAEGLG
     MVSEEGTSEK VMADDEFTCD LFRMLQLLCE GHNNDFQNYL RTQTGSTTTI NIIICTVDYL
     LRLQESISDF YWYYSGKDII DEPGKKNFSK AMTVAKQIFN SLTEYIQGPC TGNQQSLTHS
     RLWDAVVGFL HVFAHMMMKL AQDSSQIGLL KELLDLQKDM VVMLLSLLEG NVVNGTIARQ
     MVDMLVESSS NVEMILKFFD MFLKLKDIVA SDAFRDYVTD PRGLISKKDF QKAMDSQKQY
     SPSEIQFLLS CSEADENDMI NFEEFADRFQ EPAKDIGFNI AVLLTNLSEH VPHDLRLKNF
     LEQAESVLNY FRPFLGRIEI MGASRKIERI YFEISEVNRT QWEMPQVRES KRQFIFDVVN
     EGGESEKMEM FVNFCEDTIF EMNIASQISE QEEEKEEEDD DEPAEGGAEA GGGGGGDEEG
     NGEEGEPESS SAFADFINSL LNFLSIFTFR NLRRQYRRVR KMTIKQIVVG LATFFWTILI
     GILHFIYSVC KGFFLLIWQT LFGGGLVEGA KNITVTEILA SMPDPTQDEV HGDLPGEPRT
     GEEQEAGGVT DQMDTGGGEE EEEDNQDKEG GGPPRIDAPG GLGDMGIEAT VEPPTPEGTP
     LTRRKQQPEE GAAAAADGQA AEPAPAPAPA IEEPPPEPEK ADTENGEKAE KEAETKEEEK
     QEQPKEKKAK DKKNKKQHRE QGFQLWTELD IQRNKFLNYL SRNFYNLRFL ALFIAFALNF
     ILLFYKVSDS PPGEGDEVEG SGMFEGSGVG ALFEGSGLFE GSAEEMEGSG GDEGGDEEEE
     EGPVYFFLEE STGYMQPTLT FLAALHTVIA FLCIIGYNCL KIPLVIFKRE KELARKLEFD
     GLYITEQPED DDIKGQWDRL VLNTPSFPNN YWDKFVKRKV LDKYGDIYGR ERIAELLGMD
     LASLDVSQQT DKKPEEPDNS TLAWCTSIDF KYQIWKCGVV FTDGTFLYLC WYTIMSLLGH
     YNNFFYACHL LDIAIGVKDL RTILSSVTHN GKQLMMTLGL LAVVVYLYTV VAFIFFRKFY
     NKSEDEDEPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDVYELYR VVFDITFFFF
     VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI GSDYFDTTPH GFETHTLEEH
     NLANYMFFLM YLINKDETEH TGQESYVWKM YQERAWDFFP AGDCFRKQYE DQLA
//
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