ID A0A1S3RIE6_SALSA Unreviewed; 297 AA.
AC A0A1S3RIE6;
DT 12-APR-2017, integrated into UniProtKB/TrEMBL.
DT 12-APR-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Ribose-phosphate pyrophosphokinase 1 {ECO:0000256|ARBA:ARBA00040334};
DE EC=2.7.6.1 {ECO:0000256|ARBA:ARBA00013247};
DE AltName: Full=Phosphoribosyl pyrophosphate synthase I {ECO:0000256|ARBA:ARBA00042458};
GN Name=prps1 {ECO:0000313|RefSeq:XP_014052068.1};
OS Salmo salar (Atlantic salmon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC Salmonidae; Salmoninae; Salmo.
OX NCBI_TaxID=8030 {ECO:0000313|Proteomes:UP000087266, ECO:0000313|RefSeq:XP_014052068.1};
RN [1] {ECO:0000313|RefSeq:XP_014052068.1}
RP IDENTIFICATION.
RC TISSUE=Muscle {ECO:0000313|RefSeq:XP_014052068.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP)
CC that is essential for nucleotide synthesis.
CC {ECO:0000256|ARBA:ARBA00003018}.
CC -!- PATHWAY: Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose
CC 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from
CC D-ribose 5-phosphate (route I): step 1/1.
CC {ECO:0000256|ARBA:ARBA00004996}.
CC -!- SUBUNIT: Homodimer. The active form is probably a hexamer composed of 3
CC homodimers. {ECO:0000256|ARBA:ARBA00026067}.
CC -!- SIMILARITY: Belongs to the ribose-phosphate pyrophosphokinase family.
CC {ECO:0000256|ARBA:ARBA00006478}.
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DR RefSeq; XP_014052068.1; XM_014196593.1.
DR AlphaFoldDB; A0A1S3RIE6; -.
DR GeneID; 100195336; -.
DR CTD; 5631; -.
DR OrthoDB; 276387at2759; -.
DR UniPathway; UPA00087; UER00172.
DR Proteomes; UP000087266; Chromosome ssa04.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0004749; F:ribose phosphate diphosphokinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006015; P:5-phosphoribose 1-diphosphate biosynthetic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0009165; P:nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0009156; P:ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR CDD; cd06223; PRTases_typeI; 1.
DR Gene3D; 3.40.50.2020; -; 2.
DR InterPro; IPR000842; PRib_PP_synth_CS.
DR InterPro; IPR029099; Pribosyltran_N.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR005946; Rib-P_diPkinase.
DR NCBIfam; TIGR01251; ribP_PPkin; 1.
DR PANTHER; PTHR10210:SF32; RIBOSE-PHOSPHATE DIPHOSPHOKINASE; 1.
DR PANTHER; PTHR10210; RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER; 1.
DR Pfam; PF14572; Pribosyl_synth; 1.
DR Pfam; PF13793; Pribosyltran_N; 1.
DR SMART; SM01400; Pribosyltran_N; 1.
DR SUPFAM; SSF53271; PRTase-like; 1.
DR PROSITE; PS00114; PRPP_SYNTHASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide biosynthesis {ECO:0000256|ARBA:ARBA00022727};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000087266};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 20..99
FT /note="Ribose-phosphate pyrophosphokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13793"
SQ SEQUENCE 297 AA; 32640 MW; FB443CB1C8AFE56B CRC64;
MSTQHVRPKQ GWKRKATIRS VEIGESVRGE DVYIVQSGCG EINDNLMELL IMINACKIAS
ASRVTAVIPC FPYARQDKKD KSRAPISAKL VANMLSVSGA DHIITMDLHA SQIQGFFDIP
VDNLYAEPAV LKWIKENINE WKNCTIVSPD AGGAKRVTSI ADRLNVDFAL IHKERKKANE
VDRMVLVGDV KDRVAILVDD MADTCGTICH AADKLVSAGA TKVYAILTHG IFSGPAITRI
NNACFEAVVV TNTIPQEDKM KHCSKIQVID ISMILAEAIR RTHNGESVSY LFSHVPL
//
